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Venetoclax Questions: Side Effects & Post-ASCT Use
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Hello, I was diagnosed with Multiple Myeloma in September 2023 at age 37, and did the quadruplet induction therapy (dexamethasone, velcade, daratumumab, and revlimid). Initially this therapy worked, but after about 4 cycles (4 months), it stopped working and my M-spike became stagnant 0.26. As a result my doctor switched me to daily venetoclax (800mg) with dexamethasone once a week (20mg), because I have translocation 11;14. Venetoclax has worked wonders; it wiped out my M-spike from 0.26 to ZERO in just 60 days. I am now on my 3rd cycle (90 days) of venetoclax, and am scheduled to undergo autonomous stem cell transplant next month. My doctor is considering putting me back on venetoclax as a maintenance therapy after transplant, since it has worked so well for me. I have the following questions: Has anyone taken daily venetoclax (800mg) with dexamethasone for three months? If so, what were your biggest side effects (mine is erectile dysfunction, low libido, and fatigue)? If you had these side effects, did they go away once you stopped taking venetoclax? Has anyone taken venetoclax, gotten stem cell transplant, and then used venetoclax for maintenance afterwards? If so, what was the outcome?
Thank you, I look forward to your response 🙏
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