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SMM: Seeking Next Trial to Get MRD to Zero?
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After a two-year clinical trial measuring the possible effectiveness of iberdomide (solely, no other drugs) on high-risk smoldering multiple myeloma, my MRD measurements dropped from 273,088 clonal cells down to 692, which of course is great. Yet it's not as close to zero as I was hoping for. Part of the trial's intent was to see if iberdomide could be effective in arresting high-risk SMM's possible progression to MM, but could there possibly be another trial that seeks to drive that 692 down to even less? Feels like with these great results, there might also be a way to prevent MM potential (in essence, perhaps a potential 'cure'?). My team at Emory has been great but they are not aware of any clinical trial that would attempt to further reduce the clonal cell count. Anyone here, especially other providers/clinics, know of anything? Thanks.
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