Kepivance Can anyone tell me if they've had Kepivance (Palifermin) prior to an autogolous stem cell transplant (SCT)? https://www.drugs.com/kepivance.html https://www.drugs.com/pro/kepivance.html I ask because it's being suggested I take it because I've previously experienced radiation and there's a concern that when I receive my Melphalan dose before my SCT, it would be better to take the Kepivance to stave off the potential impact of mucositis and re-radiation that can be a side effect from Melphalan. Interestingly, there are two places where I can receive a SCT in my area and one recommends I take it and the other doesn't. If I do take it, I'll do so for 3 days straight starting a week before my SCT then again for 3 days straight some time after my SCT. From Google AI: Should I Take Kepivance? Based on the provided search results, Kepivance (palifermin) is a medication indicated to decrease the incidence and duration of severe oral mucositis in patients with hematologic malignancies receiving myelotoxic therapy in the setting of autologous hematopoietic stem cell support. It is not indicated for patients with non-hematologic malignancies. Before deciding whether to take Kepivance, consider the following: Your diagnosis: Kepivance is only recommended for patients with hematologic malignancies (blood cancers) undergoing autologous hematopoietic stem cell transplantation. If you have a different type of cancer, Kepivance may not be suitable for you. Your treatment plan: Kepivance is used as supportive care for preparative regimens predicted to result in ≥ WHO Grade 3 mucositis in the majority of patients. If your treatment plan does not involve myelotoxic chemotherapy and autologous stem cell transplantation, Kepivance may not be necessary. Potential side effects: Kepivance may cause common adverse reactions such as rash, fever, elevated serum amylase, pruritus, erythema, and edema. It may also interact with heparin and increase systemic exposure. Breastfeeding and fertility: Kepivance is not recommended for breastfeeding women, as it may harm the breastfed child. Additionally, animal studies suggest it may impair fertility in both males and females, although the reversibility of this effect is unknown. Alternative options: If you are considering Kepivance, discuss alternative treatments and their potential benefits and risks with your healthcare provider. Based on these factors, you should consult with your healthcare provider to determine whether Kepivance is appropriate for your specific situation. They will help you weigh the potential benefits against the risks and consider alternative options.