My father is under VPD and he has his back pain He takes his Bortezomib on Sundays with 20mg Dexa. Pain normalises for 3 days. But then picks up for the rest of the week. And during these days when he has pain, he feels very lethargic/fatigued. We do the weekly blood profiles on Sundays and all parameters are always normal. Could someone from his experience suggest, what might be the culprit for this fatigue- is it dexa effect, bone pain related as he does not feel like doing anything then.? Also, what solutions do you advice to manage the pain and this fatigue. He takes tramadol sometimes for this the pain. This has become a cycle now. Any quick remedy to fight this pain if it is unbearable. Many thanks