My Mother (74) has been on Dara VRD Induction for 6 cycles now. Her treatment had mostly been going smoothly but in March during her 6th cycle she experienced some diarrhea/gastritis, which resolved, but was followed by extreme inappetence where she really wasn't able to eat much and lost a lot of weight very quickly (7 kgs in 3 weeks). She's near Clinical Remission and was meant to be heading towards a transplant but given her current condition that is not happening. Treatment in general was put on hold to give her system time to recover but she is still experiencing extreme early satiety - she feels very full after eating extremely small amounts of food - and that feeling of fullness lasts for hours so she isn't able to eat enough to get the calories she needs to maintain her weight. Her current symptoms of concern are early satiety, post meal fullness, belching during and after meals and bloating. She is not experiencing pain or nausea, discomfort or reflux/heartburn. She has not had any diarrhea for weeks now and is not constipated either. Its mostly just these upper GI issues, but these symptoms are making making her lose her appetite and limiting what she is able to eat. Growing increasingly concerned because despite being off treatment for practically 5 weeks now and being put on a prokinetic, things are not particularly improving and I have no clarity from her doctors on what might be causing them, they don't have any diagnostics planned, nor giving me much input on what else we could be doing to help? Has anyone else experienced this? 1. Did your doctors think this was treatment related toxicity? 2. If so what did they attribute it to and was your treatment modified? 3. Did you have any diagnostics done to rule out other potential GI issues? 4. What, if anything helped with the symptoms? I would really love to hear from folks who may have experienced anything similar. Thank you so much, Aditi