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salmonWhale
Multiple Myeloma Discussion • April 3, 2025
Idea for Drug Research: Targeting Clones
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Here's my suggestion for drug research. The current approach is to design drugs that recognize specific markers (antigens in the form of proteins) on the surface of cancer cells, then kill the cells. The problem is that these markers are also on normal cells, and normal cells are also killed. This is what causes side effects, even death. Thus, a better approach would be to either 1) find a marker that occurs 100% on the cancer cells but not on normal cells - which hasn't been done yet - or, 2) design a drug (and/or its method of delivery) that will identify the presence of an entire CLONE of cells - even multiple clones - then proceed to kill ALL members of the clone and NOT kill any normal cell. Clonal cells have identical DNA, and I believe only cancer cells are clonal (with possibly more than one clone) and that normal cells cannot be clonal cells. I may be wrong, but If I'm right, such a drug may be a cure, without side effects. It must be able to determine the fact that there's a clone of many - thousands or millions - of the same clone. Right now, only a single cancer cell is targeted. The idea is to make the drug aware that there are either one, two, or thousands of clonal cells. It enables the drug to say, "Aha, there are more than one of these genetically identical cells, therefore it's a cancer. Now attack all of them."
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