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What Are Treatments For Small-Cell Lymphocytic Lymphoma?
Small-Cell Lymphocytic Lymphoma (SLL) is a type of non-Hodgkins lymphoma that affects the B-lymphocytes (proteins that create antibodies) of the immune system. It is a slow-growing lymphoma, and it is identical to chronic lymphocytic leukemia (CLL) in terms of its cancer cell characteristics and appearance. The distinction between the two is primarily based on the location of the cancer cells. In SLL, the cancer cells are primarily found in the lymph nodes, while in CLL, they are mostly in the blood and bone marrow. The treatment for SLL is often similar to that for CLL and can include a combination of chemotherapy, targeted therapy, immunotherapy, and occasionally, radiation therapy. Clinical trials may also be an option.
1. Chemotherapy
Chemotherapy is a common treatment for SLL. It involves the use of drugs to kill cancer cells or stop them from dividing. The specific drugs used in chemotherapy for SLL often include a combination of fludarabine, cyclophosphamide, and rituximab (FCR). Bendamustine, in combination with rituximab, is another common regimen. These drugs can be administered intravenously or orally.
2. Targeted Therapy
Targeted therapy is a treatment that uses drugs to identify and attack specific cancer cells without harming normal cells. In the case of SLL, targeted therapies often involve monoclonal antibodies like rituximab, obinutuzumab, or ofatumumab. These drugs specifically target the CD20 protein on the surface of B-cells. Other targeted therapies include kinase inhibitors like ibrutinib and idelalisib, which block signals that stimulate the growth of leukemia cells.
3. Immunotherapy
Immunotherapy is a treatment that uses the patient's immune system to fight cancer. It can be done by stimulating the immune system to work harder or smarter to attack cancer cells, or by giving the immune system components, such as man-made immune system proteins. In SLL, immunotherapy often involves the use of drugs like alemtuzumab, which targets the CD52 antigen on B-cells.
4. Radiation Therapy
Radiation therapy uses high-energy radiation to kill cancer cells. It is not commonly used in the treatment of SLL, but it may be used in certain cases, such as when the disease is localized to one group of lymph nodes or to relieve symptoms caused by the disease.
5. Clinical Trials
Clinical trials are not just a last resort for treating SLL. They can actually provide access to cutting-edge treatments that are not yet approved but show promise over years of testing. The choice of a clinical trial depends on a variety of factors including the patient's age, overall health, the subtype of SLL, and genetic changes in the lymphoma cells. It's important to discuss all treatment options, including goals and possible side effects, with your healthcare team to help make the best decision.
To learn more about your SLL clinical trial options, visit HealthTree's SLL Clinical Trial Finder. Utilize the advanced filter option to locate trials that you are eligible to participate in. You can create a HealthTree account to favorite your top trial options so you can discuss them with your SLL specialist.