1. What is relapsed myeloma and refractory myeloma? Video
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2. What is progressive disease? Is it the same as relapse? Video
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3. What is a Biochemical vs Clinical Relapse? Video
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4. What are the cycles of relapse and remission in myeloma? Video
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5. Why do drugs stop working? Video
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6. Do individuals become refractory to a given drug or an entire class of drugs? Video
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7. What testing should be done at relapse? What is restaging? Video
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8. What are the goals of treatment at relapse? Video
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9. With relapsed myeloma, when should you modify current therapy change dosage? Video
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10. What are the NCCN Treatment Guidelines? What strategy should be used in selecting a therapy? Video
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11. Why is it important to be consulting with a myeloma specialist at relapse? Video
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12. BETA - What treatments are available for first relapse with lenalidomide refractory disease? Video
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13. What treatments should be considered in bortezomib/velcade refractory patients at first relapse? Video
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14. BETA - What are some possible monoclonal antibodies combinations to consider at first relapse in multiple myeloma? (daratumumab, isatuximab, elotuzumab) Video
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15. What are some newer therapies with different mechanisms of action to consider at first relapse? Video
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16. What does it mean to be triple class refractory? Video
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17. Is there a role for transplant if not used upfront or a second transplant at first relapse? Video
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18. What is the role of genomics at relapse? Video
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19. Are there any targeted approaches for specific genetic subsets that patients should ask about? Video
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20. How do you decide on an appropriate treatment at relapse with so many to choose from? Video
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21. When should a patient consider a clinical trial in relapse? Video
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22. With so many options available, at what point should a patient consider getting a second opinion? Video
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23. BETA What treatments are available for patients with relapsed refractory myeloma who have received at least two prior lines of therapy but less than 4 lines of therapy? Video
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24. What is meant by t-cell redirecting therapy? Video
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25. BETA - Where should CAR-T cell therapy be positioned in the RRMM setting? Video
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26. BETA - Where should bispecific antibodies be positioned in RRMM? Video
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27. What factors should be considered when choosing between a CAR T cell therapy and a bispecific antibody therapy? Video
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28. What is a BCMA-directed Therapy? What are some FDA approved BCMA-directed therapies? Video
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29. Is there a role for conventional chemotherapy in the treatment of relapsed and refractory myeloma? Video
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30. Will an allogeneic transplant ever be considered at relapse? Video
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31. What are some promising investigational agents and novel therapies for relapsed/refractory patients? Video
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32. What is the role of supportive care throughout relapsed and refractory myeloma management? Video
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33. What is bone strengthening therapy? Video
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34. What are some tips for coping with the fear of relapse? Video
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35. What are the unmet needs and challenges in the relapsed/refractory myeloma setting? Video
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36. How can HealthTree help with assessing treatment options at relapse? Video
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37. What is Off-label Use of a Drug? Video
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38. What is Considered a Line of Therapy? Video
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39. BETA - What treatment options could patients who relapse after later line CAR-T cell therapy consider? early line CAR-T cell therapy? both CAR-T and BsAbs? Video
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