How likely is it that myelodysplastic syndromes will progress to acute myeloid leukemia?

How likely is it that myelodysplastic syndromes will progress to acute myeloid leukemia?
Is transplant still needed in the age of novel therapies?
How is chronic graft versus host disease different than acute graft versus host disease?
What are the different types of stem cell transplants?
What is MRD and why is testing for it useful in acute myeloid leukemia?