Danazol is a synthetic steroid that works by affecting the pituitary-ovarian axis. In simple terms, it reduces the production of certain hormones in the body, particularly those involved in the menstrual cycle and immune response. Danazol has weak androgenic (male hormone-like) activity and suppresses the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. This leads to a decrease in estrogen production.

In addition, danazol can decrease levels of certain antibodies and proteins in the blood, which is helpful in conditions where the immune system is overactive. For hereditary angioedema, danazol increases the levels of a protein called C1 esterase inhibitor, helping to prevent swelling attacks. Although danazol is not a standard treatment for blood cancers, it may sometimes be used to manage certain blood-related conditions, such as low platelet counts (thrombocytopenia) or other blood disorders related to immune system dysfunction.

danazol

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