Avigan directs a large laboratory working on personalized cancer vaccines and CAR T-cell therapies, has led national cancer studies and heads a clinical trials program for hematological malignancies. He also established the Randi and Brian Schwartz Family Cancer Immunotherapy and Cell Manipulation Facility, which helps to treat hundreds of patients with innovative immune-based treatments. In addition, he has served as the national principal investigator for a first-of-its-kind, academic-led trial studying a personalized cancer vaccine supervising cell production and immune studies for 18 participating sites across the United States.