Discover the world of clinical trials and how they unlock the potential to transform CLL healthcare. Curious about what clinical trials are and why you should consider participating in one? Explore the information below where you'll find explanations about the significance of clinical trials and their impact on CLL cure advancements. Gain insights into cutting-edge treatments, patient benefits, and how you can contribute to shaping the future of CLL healthcare.
Find a clinical trial through our clinical trial finder here.
Read about the latest updates in several ongoing CLL clinical trials here.
Clinical trials are research studies that patients can volunteer to participate in. Clinical trials help research communities find better ways to prevent, diagnose and/or treat cancer. Currently, only 8% of cancer patients participate in clinical trials. This is believed to be because of a lack of understanding about clinical trials and the power they have to help better CLL care.
Every clinical trial follows a specific protocol. Protocols consists of:
There should also be a very thorough and informed consent process of learning about the clinical trial before you decide to take part in it. You should learn the purpose of the trial, how long it will take, what will happen, all potential risks and benefits, and information on the privacy of your medical records.
If you want to participate, you will sign a consent form that details all of the information that has been discussed. You will be able to take that form home and refer to it at any time. Even though you have signed the consent form, you still have the right to leave the study at any time and for any reason.
Informed consent continues throughout the trial. This will give the research team an opportunity to update you on the progress of the trial as well as any side effects or other risks that have been identified.
Clinical trials are only done when there is good reason to believe that a new test or treatment can improve the care of patients. Treatments are tested in preclinical research. Preclinical research is not done with people.
After preclinical research, treatments go through a series of clinical trials. Clinical trials have five phases. The phases are described next using the example of a new medicine:
Phase 0 trials are the first clinical trials that involve people. This phase is to learn how a medicine is processed in the body, how it affects the body, and does it reach the cancer cells. A very small dose of a medicine is given to about 10 to 15 people.
This phase is generally tested in a small group of 15 to 30 patients and seeks to find out:
Phase II trials are to further analyze the safety of the medicine as well as if a medicine works. These trials are tested in groups of less than 100 patients.
Phase III trial's purpose is to compare the new medicine to the current medicine it could replace. This phase monitors the side effects of each medicine and which one works better. This phase is tested in hundreds to thousands of patients.
Patients who enroll in a Phase III clinical trial have a chance of being in one of the following randomly selected groups:
You don’t get to choose what group you are in, this is assigned at random. You will also not know which group you’re in until the trial is over.
Phase IV trials continue testing new medicines that have been recently approved by the FDA. The medicine is tested in hundreds to thousands of patients worldwide. This allows for a better understanding of short and long-term side effects, safety, and benefits of the new medicine.
All clinical trials are different. Oftentimes, the treatment itself in the clinical trial is covered by the sponsors of the study. Surrounding care such as blood tests, however, may or may not be covered by the study's sponsors and the patient will need to review insurance coverage. Consult with the clinical trial's investigators to get answers to these questions.
Other financial coverage questions you should ask the clinical trial's team include:
You need to understand the costs you'll be responsible for before participating in a trial. If you have questions, reach out to the clinical trial's investigator (listed on the study's page) or HealthTree's clinical trial study team who are here to help you navigate these questions.
Not all clinical trials are right for all patients. Each study has certain inclusion and exclusion criteria. These filtering criteria help preserve the health of patients to avoid treatments that could potentially harm them. Eligibility criteria include information about you and your overall health such as:
You are a volunteer and can choose to stop a clinical trial at any time. You should speak with your doctor first to see if stopping could affect your health, the best way to stop taking the medications, or if there are other treatment options available to you. If a clinical trial isn’t proving to be successful for you, you can have the option of stopping and starting another clinical trial or a different course of treatment.
Dr. Meghan Thompson helped explain when it’s appropriate for CLL patients to start thinking about joining a clinical trial. Watch her video below to learn more:
Dr. Thompson explained that there are usually clinical trials available for CLL patients in any stage of the cancer. For example, there are clinical trials for patients before treatment starts to help review the best supportive care like prevention of infection and how to best support the immune system. Other clinical trials help refine and improve the current standard of care for the patient’s first treatment.
For CLL patients whose cancer has come back after a line of treatment or whose disease has stopped responding to treatments (relapsed/refractory), there are also clinical trials available. Some of these include trying new potentially better medicines than the current standard of care.
Dr. Thompson recommends CLL patients talk with their doctor at each stage of their care journey to review if a clinical trial is right for them.
Clinical trials have the potential to help better the treatment landscape for the CLL patient community. We invite you to consider joining a clinical trial you are eligible for to help us in this goal. See here to check out clinical trials you may qualify for!
Discover the world of clinical trials and how they unlock the potential to transform CLL healthcare. Curious about what clinical trials are and why you should consider participating in one? Explore the information below where you'll find explanations about the significance of clinical trials and their impact on CLL cure advancements. Gain insights into cutting-edge treatments, patient benefits, and how you can contribute to shaping the future of CLL healthcare.
Find a clinical trial through our clinical trial finder here.
Read about the latest updates in several ongoing CLL clinical trials here.
Clinical trials are research studies that patients can volunteer to participate in. Clinical trials help research communities find better ways to prevent, diagnose and/or treat cancer. Currently, only 8% of cancer patients participate in clinical trials. This is believed to be because of a lack of understanding about clinical trials and the power they have to help better CLL care.
Every clinical trial follows a specific protocol. Protocols consists of:
There should also be a very thorough and informed consent process of learning about the clinical trial before you decide to take part in it. You should learn the purpose of the trial, how long it will take, what will happen, all potential risks and benefits, and information on the privacy of your medical records.
If you want to participate, you will sign a consent form that details all of the information that has been discussed. You will be able to take that form home and refer to it at any time. Even though you have signed the consent form, you still have the right to leave the study at any time and for any reason.
Informed consent continues throughout the trial. This will give the research team an opportunity to update you on the progress of the trial as well as any side effects or other risks that have been identified.
Clinical trials are only done when there is good reason to believe that a new test or treatment can improve the care of patients. Treatments are tested in preclinical research. Preclinical research is not done with people.
After preclinical research, treatments go through a series of clinical trials. Clinical trials have five phases. The phases are described next using the example of a new medicine:
Phase 0 trials are the first clinical trials that involve people. This phase is to learn how a medicine is processed in the body, how it affects the body, and does it reach the cancer cells. A very small dose of a medicine is given to about 10 to 15 people.
This phase is generally tested in a small group of 15 to 30 patients and seeks to find out:
Phase II trials are to further analyze the safety of the medicine as well as if a medicine works. These trials are tested in groups of less than 100 patients.
Phase III trial's purpose is to compare the new medicine to the current medicine it could replace. This phase monitors the side effects of each medicine and which one works better. This phase is tested in hundreds to thousands of patients.
Patients who enroll in a Phase III clinical trial have a chance of being in one of the following randomly selected groups:
You don’t get to choose what group you are in, this is assigned at random. You will also not know which group you’re in until the trial is over.
Phase IV trials continue testing new medicines that have been recently approved by the FDA. The medicine is tested in hundreds to thousands of patients worldwide. This allows for a better understanding of short and long-term side effects, safety, and benefits of the new medicine.
All clinical trials are different. Oftentimes, the treatment itself in the clinical trial is covered by the sponsors of the study. Surrounding care such as blood tests, however, may or may not be covered by the study's sponsors and the patient will need to review insurance coverage. Consult with the clinical trial's investigators to get answers to these questions.
Other financial coverage questions you should ask the clinical trial's team include:
You need to understand the costs you'll be responsible for before participating in a trial. If you have questions, reach out to the clinical trial's investigator (listed on the study's page) or HealthTree's clinical trial study team who are here to help you navigate these questions.
Not all clinical trials are right for all patients. Each study has certain inclusion and exclusion criteria. These filtering criteria help preserve the health of patients to avoid treatments that could potentially harm them. Eligibility criteria include information about you and your overall health such as:
You are a volunteer and can choose to stop a clinical trial at any time. You should speak with your doctor first to see if stopping could affect your health, the best way to stop taking the medications, or if there are other treatment options available to you. If a clinical trial isn’t proving to be successful for you, you can have the option of stopping and starting another clinical trial or a different course of treatment.
Dr. Meghan Thompson helped explain when it’s appropriate for CLL patients to start thinking about joining a clinical trial. Watch her video below to learn more:
Dr. Thompson explained that there are usually clinical trials available for CLL patients in any stage of the cancer. For example, there are clinical trials for patients before treatment starts to help review the best supportive care like prevention of infection and how to best support the immune system. Other clinical trials help refine and improve the current standard of care for the patient’s first treatment.
For CLL patients whose cancer has come back after a line of treatment or whose disease has stopped responding to treatments (relapsed/refractory), there are also clinical trials available. Some of these include trying new potentially better medicines than the current standard of care.
Dr. Thompson recommends CLL patients talk with their doctor at each stage of their care journey to review if a clinical trial is right for them.
Clinical trials have the potential to help better the treatment landscape for the CLL patient community. We invite you to consider joining a clinical trial you are eligible for to help us in this goal. See here to check out clinical trials you may qualify for!
about the author
Megan Heaps
Megan joined HealthTree in 2022. As a writer and the daughter of a blood cancer patient, she is dedicated to helping patients and their caregivers understand the various aspects of their disease. This understanding enables them to better advocate for themselves and improve their treatment outcomes. In her spare time, she enjoys spending time with her family.