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A recent survey conducted by HealthTree Foundation explores how individuals living with blood cancer are navigating life emotionally, spiritually, and socially following their diagnosis. The results paint an encouraging picture of post-traumatic growth, resilience, and the deep meaning many patients find during their cancer journey.

The study surveyed 251 blood cancer patients and asked questions related to life satisfaction, emotional well-being, relationships, purpose, and faith. Despite the adversity that comes with a cancer diagnosis, many respondents reported profound personal transformation and growth.

A Path Through Adversity: Signs of Post-Traumatic Growth

One of the most uplifting findings of the survey was that many patients are experiencing growth as a result of their cancer experience.

Changed Priorities: 75% of respondents said their values shifted moderately or more as a result of their diagnosis
Appreciation for the Value of Life: 80% gained a moderate or deeper appreciation for life’s value
Increased Resilience: 68% now feel moderately or more confident handling difficulties
Personal Strength and Connection: Many discovered they were stronger than they thought and gained a greater sense of closeness with others

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“I learned a great deal about how wonderful people are,” one respondent reflected—an insight shared by 84% of participants.
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What Flourishing Looks Like Today

The survey invited participants to rate how they feel today in several aspects of daily living.

Life Satisfaction and Happiness

Despite the physical and emotional challenges of living with blood cancer, patients have:

7.10 out of 10 average life satisfaction
7.1 out of 10 happiness rating

Many respondents reported feeling generally satisfied with life, with 50% scoring themselves 8 or higher.

Mental and Physical Health

Patients rated their physical health at an average of 6.5 out of 10, and, encouragingly, rated their mental health higher at an average of 7.3 out of 10. These scores suggest many patients are managing their condition with a relatively strong sense of overall well-being.

Meaning and Purpose

The survey also found high levels of personal meaning and purpose:

86% of people feel the things they do in life are worthwhile
7.2 out of 10 average understanding of their life's purpose

Faith and Spirituality: Meaning Beyond Medicine

The survey revealed a wide range of spiritual and religious experiences and beliefs.

85% believe in God or a higher power
37% believe God is active in their lives
26% believe in a higher power or divine being
66% attend religious services
64% engage in personal spiritual practices monthly or more

Many respondents described a strong, supportive relationship with God, while others expressed uncertainty or non-belief. Regardless of belief system, spirituality appeared to be a meaningful dimension in coping with illness for a large number of participants.

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Why This Research Matters

This survey serves as a powerful reminder that a cancer diagnosis touches every aspect of a person’s life, not just the physical.

Because of adversity and not despite it, patients are finding ways to grow, reflect, and live with greater purpose. These stories of flourishing underscore the importance of holistic care—care that nurtures the body, mind, and spirit.

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“We need to understand not just how patients survive—but how they thrive.” shared HealthTree's research team.
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Add Your Voice

Both patients and researchers would like to know more about your life experience dealing with a blood cancer diagnosis. It should not take more than 10 minutes to complete. To contribute to this survey, click the button below.

Participate in the Flourishing Survey

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People living with blood cancer may receive corticosteroids (sometimes referred to as steroids) as part of their treatment plan. In this article, you will learn how corticosteroids work, how they are used alongside blood cancer treatments, and important safety considerations.

What corticosteroids are and how they work in the body

Corticosteroids like prednisone and dexamethasone are treatments designed to mimic hormones naturally produced by the adrenal glands, which sit above the kidneys. These hormones play important roles in the body's response to stress, inflammation, and immune system activity.

Corticosteroids work through both \"genomic\" and \"non-genomic\" pathways:

Genomic effects: Once inside a cell, corticosteroids bind to receptors and move into the nucleus to change how certain genes are expressed. This mainly decreases the production of inflammatory molecules.
Non-genomic effects: Corticosteroids can also act quickly at the cell membrane, blocking early stages of inflammation within minutes.

Understanding this is important because it explains why corticosteroids can act both rapidly and over time to control treatment-related symptoms.

Corticosteroids to support blood cancer treatments

Corticosteroids are used before or alongside cancer therapies. The benefits they provide include:

Reducing allergic-like reactions
Managing inflammation
Decreasing nausea and vomiting
Improving a poor appetite

This supportive use helps patients tolerate their blood cancer treatment better and maintain a higher quality of life.

Side effects and what patients should know

While corticosteroids are helpful, they also come with potential risks. Common side effects include:

Increased risk of infections
High blood sugar levels
Mood changes (such as anxiety or irritability)
Weight gain
Bone loss over time

The risk of these effects often depends on the dose and how long the medicine is taken. For people with blood cancers, this means that careful monitoring by your healthcare team is necessary. Special consideration may also be needed during treatments like CAR T-cell therapy, where research suggests corticosteroids at high doses for long periods of time should be limited to maintain treatment effectiveness.

Summary

Corticosteroids support blood cancer treatments by reducing inflammation and helping control immune responses. When given at the correct dose for the right amount of time, they can improve how well treatment is tolerated and symptoms are managed. Understanding their benefits and risks can help individuals and care teams make informed choices during the treatment process.

We need your help! Easily contribute to blood cancer research

If you are living with blood cancer, we need your help improving patient outcomes for all by taking simple, anonymous surveys that contribute to real-world research in HealthTree Cure Hub®. Click the button below to get started!

Make an Impact with Brief Blood Cancer Surveys

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Sources:

","language":"EN","metaDescription":"Learn how corticosteroids are used in blood cancer treatment, their benefits, and side effects to be aware of.","metaTitle":"How Are Steroids Used in Blood Cancer Treatment?","publishedAt":{"_type":"Date","value":"Tue Apr 29 2025 06:00:00 GMT+0000 (Coordinated Universal Time)"},"seoKeywords":"corticosteroids in blood cancer, steroids leukemia treatment, steroids lymphoma therapy, prednisone blood cancer, dexamethasone blood cancer, blood cancer treatment support, steroids chemotherapy side effects, steroids inflammation management blood cancer","slug":"corticosteroids-use-blood-cancer-treatment","status":"ACTIVE","title":"How Are Steroids Used in Blood Cancer Treatment?","updatedAt":{"_type":"Date","value":"Wed Apr 30 2025 15:49:55 GMT+0000 (Coordinated Universal Time)"}},"included":{"category":{"data":{"createdAt":{"_type":"Date","value":"Thu Jul 07 2022 16:34:03 GMT+0000 (Coordinated Universal Time)"},"disease":{"_type":"DocumentReference","path":"diseases/GxAhXAnh3drV4xY5Vf3A"},"diseases":[{"_type":"DocumentReference","path":"diseases/GxAhXAnh3drV4xY5Vf3A"},{"_type":"DocumentReference","path":"diseases/WCJo8IouncjDW6exT1YS"},{"_type":"DocumentReference","path":"diseases/cll"},{"_type":"DocumentReference","path":"diseases/t8f3E99OdM9XZe1d1ASM"},{"_type":"DocumentReference","path":"diseases/eBIxYtdHAYhTTs5L9bcC"},{"_type":"DocumentReference","path":"diseases/EkjGB5kileTKP2vnTWhV"},{"_type":"DocumentReference","path":"diseases/WNjIFmDibXhTFneCh4dG"},{"_type":"DocumentReference","path":"diseases/leukemia"},{"_type":"DocumentReference","path":"diseases/E7FvorVuNJjGzy9wH7fy"},{"_type":"DocumentReference","path":"diseases/chronic-myelomonocytic-leukemia"},{"_type":"DocumentReference","path":"diseases/hodgkin-lymphoma"},{"_type":"DocumentReference","path":"diseases/non-hodgkins-lymphoma"},{"_type":"DocumentReference","path":"diseases/lymphoma"},{"_type":"DocumentReference","path":"diseases/mantle-cell-lyphoma"},{"_type":"DocumentReference","path":"diseases/lymphoblastic-lymphoma"},{"_type":"DocumentReference","path":"diseases/tDYO4O8HTJT5dAHT6xis"}],"migratedReason":"global-community","migratedReason2":"fix global-community categories","migratedSlug":true,"oldSlug":"myeloma-basics","sectionConfig":{"news":{"description":"Our Core Education articles help you understand your cancer so you are equipped to find a good care team, ask appropriate questions, and become your own best advocate.","metaDescription":"Learn 101 Education to help you know more about your cancer, what tests and treatments are available to you, and more.","metaTitle":"Core Education - HealthTree Foundation","order":3,"tileOrder":3,"type":"LARGE_TILE"}},"sections":["NEWS"],"slug":"core-education","status":"ACTIVE","title":"Core Education","updatedAt":{"_type":"Date","value":"Fri Apr 12 2024 20:21:23 GMT+0000 (Coordinated Universal Time)"}},"included":{},"ref":{"_type":"DocumentReference","path":"apps/community/categories/MB3xw38fuKkx0LdszsrL"},"snapshot":{"exists":true,"id":"MB3xw38fuKkx0LdszsrL","ref":{"_type":"DocumentReference","path":"apps/community/categories/MB3xw38fuKkx0LdszsrL"}}}},"ref":{"_type":"DocumentReference","path":"apps/community/articles/ZlMrOftm1a3LkZEvr50Z"},"snapshot":{"exists":true,"id":"ZlMrOftm1a3LkZEvr50Z","ref":{"_type":"DocumentReference","path":"apps/community/articles/ZlMrOftm1a3LkZEvr50Z"}}},{"data":{"author":{"_type":"DocumentReference","path":"apps/community/authors/Y1TeubuOek8X0mlZ691N"},"category":{"_type":"DocumentReference","path":"apps/community/categories/MB3xw38fuKkx0LdszsrL"},"createdAt":{"_type":"Date","value":"Fri Mar 07 2025 21:33:55 GMT+0000 (Coordinated Universal Time)"},"disease":{"_type":"DocumentReference","path":"diseases/chronic-myelomonocytic-leukemia"},"diseases":[{"_type":"DocumentReference","path":"diseases/chronic-myelomonocytic-leukemia"}],"headerImageUrl":"https://healthtree.org/images-resize?imageUrl=https%253A%252F%252Ffirebasestorage.googleapis.com%252Fv0%252Fb%252Fhealthtree-production.appspot.com%252Fo%252Fgallery%25252Fpublic%25252Fgene%252520study%252520dna%252520chain%252520mutations%252520genetic_9f9fb020-b800-4cf3-b32f-ce18edca8ca0.jpg%253Falt%253Dmedia","htmlContent":"

Chronic myelomonocytic leukemia (CMML) is a type of blood cancer where abnormal monocytes (a type of white blood cell) growth occurs in the bone marrow. These changes are often related to specific mutations in a certain gene called TET2.

What Is TET2?

TET2 is the name of a gene that produces a protein called tet methylcytosine dioxygenase 2. When this protein functions properly, it can be a tumor suppressor, which prevents cells from growing and dividing uncontrollably. It is found throughout the body and is important in developing blood cells. It is predominantly seen in the spleen and bone marrow.

Mutated TET2 Impact

Mutations in TET2 are seen in approximately 30% of people with myeloid malignancies, such as myelodysplastic syndromes, chronic myelomonocytic leukemia, and myeloproliferative neoplasms. They are also the most frequent mutations identified in peripheral T-cell lymphomas. They are a significant genetic factor contributing to the development of CMML, often associated with a poorer prognosis for patients.

A recent study discovered that the mutated TET2 changes the body’s RNA, altering the structure and pathway of this protein. This leads to an open environment that allows blood cancer cells to grow. The study uncovered that MBD6 is a great target for treating myeloid malignancies with the TET2 mutation.

Almost a decade ago, it was discovered that 10% of people aged 70 and older who have the TET2 mutation (and others) can develop clonal hematopoiesis of indeterminate potential (CHIP). These patients have a higher possibility of developing myeloid cancer and cardiovascular diseases.

How Are CMML And TET2 Connected?

Mutations in the TET2 gene are commonly found in CMML patients, often occurring alongside other genetic abnormalities like ASXL1 and RUNX1 mutations. When TET2 is mutated, its ability to remove methyl from the DNA is impaired, leading to abnormal gene expression and uncontrolled cell growth, contributing to the development of CMML. The presence of a TET2 mutation in a CMML patient can be used as a prognostic marker, as it is often linked to a more aggressive disease course and poorer overall survival.

Conclusion

TET2 plays a pivotal role in the development of CMML. Understanding what role mutations play in a disease, treatment can be tailored and specific to the patient and improving the overall efficacy of therapy.

“This study is a turning point potentially leading to the exploration of several players within this pathway that could be targets for therapeutic intervention.” - Mingjiang Xu, molecular medicine professor at the Joe R. and Teresa Lozano Long School of Medicine.

You can keep learning with HealthTree's comprehensive updates on research news, conferences and more. Click the button below to browse our different article categories.

Read More CMML News

Source:

Gene-mutation pathway discovery paves way for targeted blood cancers therapies

","language":"EN","metaDescription":"Learn how TET2 mutations affect CMML, their role in prognosis, and potential new therapeutic targets like MBD6 for treating myeloid malignancies.","metaTitle":"TET2 Mutations in CMML Impact & Treatment Insights","publishedAt":{"_type":"Date","value":"Tue Apr 01 2025 06:00:00 GMT+0000 (Coordinated Universal Time)"},"seoKeywords":"TET2 mutation, CMML genetics, myeloid malignancies, TET2 and CMML, CMML prognosis, TET2 gene function, mutated TET2, CMML treatment, MBD6 target, CHIP and TET2","slug":"tet2-mutations-role-in-cmml","status":"ACTIVE","title":"How TET2 Plays A Pivotal Role In CMML","updatedAt":{"_type":"Date","value":"Fri Mar 07 2025 23:37:03 GMT+0000 (Coordinated Universal Time)"}},"included":{"category":{"data":{"createdAt":{"_type":"Date","value":"Thu Jul 07 2022 16:34:03 GMT+0000 (Coordinated Universal Time)"},"disease":{"_type":"DocumentReference","path":"diseases/GxAhXAnh3drV4xY5Vf3A"},"diseases":[{"_type":"DocumentReference","path":"diseases/GxAhXAnh3drV4xY5Vf3A"},{"_type":"DocumentReference","path":"diseases/WCJo8IouncjDW6exT1YS"},{"_type":"DocumentReference","path":"diseases/cll"},{"_type":"DocumentReference","path":"diseases/t8f3E99OdM9XZe1d1ASM"},{"_type":"DocumentReference","path":"diseases/eBIxYtdHAYhTTs5L9bcC"},{"_type":"DocumentReference","path":"diseases/EkjGB5kileTKP2vnTWhV"},{"_type":"DocumentReference","path":"diseases/WNjIFmDibXhTFneCh4dG"},{"_type":"DocumentReference","path":"diseases/leukemia"},{"_type":"DocumentReference","path":"diseases/E7FvorVuNJjGzy9wH7fy"},{"_type":"DocumentReference","path":"diseases/chronic-myelomonocytic-leukemia"},{"_type":"DocumentReference","path":"diseases/hodgkin-lymphoma"},{"_type":"DocumentReference","path":"diseases/non-hodgkins-lymphoma"},{"_type":"DocumentReference","path":"diseases/lymphoma"},{"_type":"DocumentReference","path":"diseases/mantle-cell-lyphoma"},{"_type":"DocumentReference","path":"diseases/lymphoblastic-lymphoma"},{"_type":"DocumentReference","path":"diseases/tDYO4O8HTJT5dAHT6xis"}],"migratedReason":"global-community","migratedReason2":"fix global-community categories","migratedSlug":true,"oldSlug":"myeloma-basics","sectionConfig":{"news":{"description":"Our Core Education articles help you understand your cancer so you are equipped to find a good care team, ask appropriate questions, and become your own best advocate.","metaDescription":"Learn 101 Education to help you know more about your cancer, what tests and treatments are available to you, and more.","metaTitle":"Core Education - HealthTree Foundation","order":3,"tileOrder":3,"type":"LARGE_TILE"}},"sections":["NEWS"],"slug":"core-education","status":"ACTIVE","title":"Core Education","updatedAt":{"_type":"Date","value":"Fri Apr 12 2024 20:21:23 GMT+0000 (Coordinated Universal Time)"}},"included":{},"ref":{"_type":"DocumentReference","path":"apps/community/categories/MB3xw38fuKkx0LdszsrL"},"snapshot":{"exists":true,"id":"MB3xw38fuKkx0LdszsrL","ref":{"_type":"DocumentReference","path":"apps/community/categories/MB3xw38fuKkx0LdszsrL"}}}},"ref":{"_type":"DocumentReference","path":"apps/community/articles/8NIOKXbY62I6i78paKQC"},"snapshot":{"exists":true,"id":"8NIOKXbY62I6i78paKQC","ref":{"_type":"DocumentReference","path":"apps/community/articles/8NIOKXbY62I6i78paKQC"}}},{"data":{"author":{"_type":"DocumentReference","path":"apps/community/authors/Y1TeubuOek8X0mlZ691N"},"category":{"_type":"DocumentReference","path":"apps/community/categories/MB3xw38fuKkx0LdszsrL"},"createdAt":{"_type":"Date","value":"Fri Mar 07 2025 19:58:27 GMT+0000 (Coordinated Universal Time)"},"disease":{"_type":"DocumentReference","path":"diseases/GxAhXAnh3drV4xY5Vf3A"},"diseases":[{"_type":"DocumentReference","path":"diseases/chronic-myelomonocytic-leukemia"}],"headerImageUrl":"https://healthtree.org/images-resize?imageUrl=https%253A%252F%252Ffirebasestorage.googleapis.com%252Fv0%252Fb%252Fhealthtree-production.appspot.com%252Fo%252Fgallery%25252Fpublic%25252Fshutterstock_1666109344_822d26ec-251b-475c-b9b9-b1720a8610ac.jpg%253Falt%253Dmedia","htmlContent":"

Hypomethylating agents (HMAs) are a class of medications that treat chronic myelomonocytic leukemia (CMML) by blocking DNA methylation (a chemical process that regulates gene expression in DNA). This reprograms cancer cells and impedes their growth. They are the only FDA-approved treatment for CMML. However, they are less effective for proliferative CMML subtypes with RAS mutations.

How Do HMAs Work?

HMAs are considered the standard treatment for CMML. They can improve blood cell counts and decrease the need for transfusions.

By reversing the DNA methylation, they can reprogram tumor cells.
They can activate genes that help healthy cells mature.
They can kill cells that are dividing abnormally quickly.
HMAs are believed to re-express tumor suppressors.
Patients who progress to acute myeloid leukemia (AML) after responding to HMAs have a median overall survival of 8 months.

However, HMAs can also induce cytopenias (low levels of red blood cells/white blood cells/platelets), especially in the early stages of treatment. This can lead to dose restrictions, treatment delays, or discontinuation. Other side effects include nausea and vomiting, diarrhea or constipation, weakness, and fatigue. Adding growth factors to HMA treatment may help prevent this.

How Are HMAs Used?

HMAs are often preferred for patients who are not eligible for transplant. Treatment usually starts when CMML is symptomatic or progressive and is typically administered by IV infusion. HMAs stop DNA methyltransferase (DNMT- an enzyme that adds methyl groups to DNA molecules). This re-expresses tumor suppressors and triggers the death of leukemic cells.

Azacitidine (Vidaza): has effects on both DNA and RNA.
Decitabine (Dacogen): acts only at the DNA level.
Decitabine and Cedazuridine (Inqovi).

Other Treatments For CMML

Hydroxyurea: A chemotherapy drug that can help some CMML patients live longer.
Pembrolizumab: A humanized monoclonal antibody that may be effective in patients who failed HMA treatment.
A combination of HMAs and Venetoclax has shown good results in CMML, with an overall response rate of 62%.
In 2023, the FDA granted fast-track designation to IO-202 for treating patients with relapsed/refractory CMML. This anti-LILRB4 monoclonal antibody is being investigated as an immunotherapy for blood cancers. As of 2024, at the American Hematology Association, updates from a phase 1 trial showed promising results.

Conclusion

Hypomethylating agents (HMAs) are the standard of care for treating CMML as chemotherapy. Currently, immunotherapy for CMML is not available. Therefore, using HMAs after being diagnosed can be more effective.

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Source:

Are Hypomethylating Agents the Best First-Line Choice for Treating CMML?

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Leukemia is the term for a diverse group of blood cancers that arise from the dysfunctional overproduction of blood cells in the bone marrow.

\n\n

It is classified as acute or chronic based on the time it takes to develop and the type of blood cell it affects.

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Treatment depends on a person’s type of leukemia but often involves chemotherapy. Multiple genetic and environmental risk factors are identified in the development of leukemia.

\n\n

According to the Surveillance, Epidemiology, and End Results (SEER) database, there were 61,090 estimated new cases of leukemia in 2021, accounting for 3.2% of all new cancer cases. This makes leukemia the 10th most common cancer in the United States.

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How do I tell the difference between acute and chronic leukemia?

\n\n

To better understand the differences between acute and chronic leukemia, it’s important to be familiar with the terms “blast” and “monoclonal” because that’s how doctors refer to the characteristics of the cells that can be found in the bone marrow in abnormal quantities:

\n\n

Blasts: immature and dysfunctional cells that should normally comprise 1% to 5% of bone marrow cells.
Monoclonal cells: mature, but dysfunctional cells due to mutations in the bone marrow cells; finding this type of cell is abnormal in a test.

\n\n

What is Chronic Leukemia?

\n\n

Chronic leukemia results from a failure in the cell’s life cycle after they have matured. The adult cells can often still function to some extent, which is why some patients don’t present symptoms. There are two types of chronic leukemia: chronic lymphocytic leukemia (CLL) and chronic myeloid leukemia (CML).

\n\n

What is Acute Leukemia?

\n\n

Acute leukemia occurs when cell development stops early in the cell’s life cycle, making the cells immature and unpredictable. In acute myeloid leukemia, relapse is common. However, there is a lower chance of leukemia cells returning after chemotherapy in acute lymphocytic leukemia.
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What Causes Acute and Chronic Leukemia?

\n\n

Both conditions are associated with genetic changes that cause the growth of abnormal cells in the bone marrow and have complex genetics.
\nSome risk factors linked to genetic changes have been identified:

\n\n

Congenital syndromes: Klinefelter, Down syndrome, Fanconi anemia, Li-Fraumeni syndrome, among others
Germline mutations: a change in a body's reproductive cell (egg or sperm) that becomes incorporated into the DNA of every cell in the body of the offspring
Viral infections: Epstein Barr virus, human T-lymphotropic virus
Radiation exposure
Environmental exposure to benzene
Smoking history
Previous chemotherapy with alkylating agents and topoisomerase II agents

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\n\n

How Many Types of Leukemia Exist?

\n\n

There are four types of leukemia: two are acute, and two are chronic.

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Each is characterized by different characteristics in the cells that evolve into cancer cells and the age group in which they are commonly diagnosed. Knowing their genetic characteristics can also help researchers develop new ways to treat leukemia to increase the patient’s survival rate and quality of life.
\n

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$\"\"$

\n\n

There are rarer types of leukemia that share some characteristics of lymphocytic leukemias and are considered subtypes of chronic or acute lymphocytic leukemia (CLL and ALL).

\n\n

Prolymphocytic leukemia (PLL)
Large granular lymphocyte leukemia (LGL)
Hairy cell leukemia (HCL)
Myelodysplastic syndromes (MDS) are conditions related to leukemia that are also rare and commonly evolve into acute myeloid leukemia (AML).

\n\n

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\n\n

This is why it is very important to continue active research on <disease name> patients so that their progression can be prevented one day. If you want to stay updated with <disease name> treatment advances, join our newsletter!
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SUBSCRIBE TO NEWSLETTER

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Source:

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https://www.ncbi.nlm.nih.gov/books/NBK560490/

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We are proud to announce that our CEO, Jenny Ahlstrom, has been recognized as a 2025 Remarkable Women Honoree by ABC4 Utah for her groundbreaking work in healthcare innovation and cancer research through the HealthTree Foundation.

Featured in ABC4's Women's History Month special segment, our founder was celebrated for turning her cancer diagnosis into a transformative mission with global impact. At age 43, following her diagnosis with multiple myeloma, Jenny combined her technology expertise with a passionate drive to improve patient care, establishing the HealthTree Foundation. Watch Jenny's inspiring interview below:

Under her leadership, our foundation has revolutionized patient support and cancer research through three key pillars:

Comprehensive education through podcasts, webinars, and our dedicated university platform
Community support connecting patients and caregivers
An innovative data registry accelerating critical research in blood cancer

This recognition is particularly meaningful because we have transformed traditional patient advocacy by applying technology solutions to healthcare challenges. The impact of our work extends beyond multiple myeloma, with the HealthTree model showing promise for application across various blood cancers and other diseases.

We congratulate our CEO on this recognition and her leadership of the HealthTree Foundation's mission to accelerate cancer research and improve patient outcomes.

Join HealthTree Community

At HealthTree, we understand the immense value of shared community and support. That's why we've established Regional Cure Teams – a supportive network powered by volunteers to serve as a critical extension of HealthTree Foundation in your region.

Join Your Regional Cure Team

We're thrilled to share some exciting news! Our CEO and Founder, Jenny Ahlstrom, has been named to Inc.'s 2025 Female Founders 500 list. This recognition celebrates the most innovative women entrepreneurs who are making a real difference in the world, and we couldn't be prouder of Jenny's inclusion among these remarkable leaders.

As many in our community know, Jenny's journey is deeply personal. As a multiple myeloma patient herself, she understood firsthand the frustrations and challenges that cancer patients face. This personal experience drove her to create something truly transformative – a platform that bridges the gap between patients and researchers in ways never done before.

Under Jenny's leadership, HealthTree Foundation is pioneering a revolutionary cancer research approach. We've developed a comprehensive suite of over 14 integrated technology abilities that do something amazing: they give patients the power to actively contribute to finding cures. Our platform can support all cancers, making us a leader in Digital Health Advocacy.

This recognition is particularly meaningful because it acknowledges our unique approach to solving one of healthcare's biggest challenges. Traditional cancer research often struggles with limited access to patient data, but HealthTree's direct-to-patient model is changing that narrative. By building trust and long-term relationships with patients, we're creating a more complete picture of the cancer journey that researchers can use to accelerate discoveries.

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\"We are revolutionizing cancer research by using technology that links patients and their data with researchers for faster cures,\" Jenny shared upon receiving this honor. \"Providing patients with abilities that enable them to become cure contributors is the future of personalized medicine.\"
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This recognition from Inc. comes after a rigorous selection process, during which thousands of applications were reviewed through multiple rounds of judging. The selection considered quantifiable metrics like growth and impact as well as qualitative factors that demonstrate true innovation and leadership in the field.

We're excited about this recognition not just as an award, but as a validation of our mission to transform cancer research through patient empowerment and technological innovation. With over 10,000 patients already contributing real-world data through our HealthTree Cure® Hub Registry, we're proving that when patients and researchers work together, we can accelerate the path to better treatments and cures.

Thank you to our entire community – patients, researchers, supporters, and team members – who make this work possible. This recognition belongs to all of us who believe in the power of patient-driven research to change the future of cancer care.

!AD!

Ready to Become a Cure Contributor?

Are you or a loved one affected by a blood cancer? Join thousands of others who are actively contributing to blood cancer research through the HealthTree Cure Hub® Registry. Sign up today and become part of the movement transforming cancer research.

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This Multiple Myeloma Awareness Month, we are announcing the launch of our new mobile app. Designed to bring the power of the HealthTree platform directly to patients' fingertips, the app enables users to access vital disease education, connect with a supportive community, and contribute to groundbreaking research – anytime, anywhere.

For years, HealthTree has been a trusted online resource for blood cancer patients, offering tools to help them navigate their diagnosis and treatment. Now, with the launch of the app, these essential resources are more accessible and convenient than ever before.

The platform links to comprehensive blood cancer education, including news, the HealthTree University video series, podcasts, webinars, patient guides, and patient navigators for each type of blood cancer.

The HealthTree app also enables connections to other patients for each specific blood cancer through its social media feature, HealthTree Connect, as well as with volunteer regional HealthTree Cure Teams and myeloma Coaches.

Notably, the HealthTree Cure Hub^® Registry is also included in the mobile app. The Cure Hub Registry invites patients to securely link their medical records into a centralized, patient-controlled hub to track their blood cancer, find their twin, search for personalized clinical trials, and contribute to research by completing surveys and participating in studies, helping advance cures for blood cancers. Through the app, patients can be notified when their medical records connections need to be renewed, making sure their data is up-to-date.

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Dave Bruacht, a myeloma patient, HealthTree Coach and beta app user said, \"The HealthTree app has been an indispensable tool in my coaching, seamlessly bridging the gap between complex health information and those I support. Its intuitive design on both my iPhone and iPad makes sharing vital resources incredibly efficient, truly amplifying my ability to educate and empower.\"
\n

!AD!

Experience the future of blood cancer care. Watch our exclusive app launch and demo to discover how HealthTree can transform your treatment journey. From having all your labs in one place to instant community support, see all the groundbreaking features in action!

Watch HealthTree App Demo

Download Now and Find Your Community

The all-new HealthTree app puts expert knowledge and a supportive community right in your pocket.

Available on App Store
Available on Google Play

!AD!

This announcement is the second of five technical innovations that HealthTree will reveal during Myeloma Awareness Month. Don't miss our next breakthrough - join us for Myeloma Monday!

$\"\"$

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Jenny Ahlstrom, founder of the HealthTree Foundation, was recently interviewed on The Pulse podcast. The episode, \"Pushing for Change,\" aired on February 14, 2025, and explores what motivates individuals to make a difference.

In the comprehensive interview, Jenny discussed how HealthTree's innovative platform allows blood cancer patients to input their medical history, treatment responses, and side effects, creating a valuable database for researchers. This patient-driven approach has already collected data from over 12,000 multiple myeloma patients, making it an invaluable resource for understanding treatment patterns and outcomes.

Listen to Jenny’s personal experience with multiple myeloma and how it led her to create HealthTree. Diagnosed in 2010, she discovered a critical gap in the availability of data-driven treatment options for patients like herself. This experience fueled her passion to establish HealthTree, a non-profit organization providing vital information and support to blood cancer patients and researchers.

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\"HealthTree can help researchers use best-in-class treatment options [for their patients] and can drive them towards cures,\" Ahlstrom stated in the interview. She further emphasized her dedication to patient support, adding, \"I love supporting patients. We just want faster cures, that's it!\"
\n

The Pulse, hosted by Maiken Scott, delves into the health and science world, exploring cutting-edge research and life-changing innovations. The episode featuring Jenny Ahlstrom also includes segments on the science behind effective protests and the ongoing debate surrounding water fluoridation.

Special thanks to Maiken Scott, Host and Executive Producer, and Producer Nichole Currie for their kindness and support.

About HealthTree Foundation

HealthTree is a global nonprofit organization using innovation to save lives. Our cutting-edge technology unites patients and researchers to help people with blood cancer live better and longer and leads the search for a cure.

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HealthTree Foundation celebrated excellence in blood cancer research by presenting its 2024 HealthTree Awards during a special reception at the American Society of Hematology (ASH) annual meeting in San Diego this December.

Dr. Rahul Banerjee of Fred Hutch Cancer Center received the inaugural HealthTree Innovation Award for his groundbreaking research on dexamethasone use and cataract severity in multiple myeloma patients. His work has made significant contributions to the \"down-with-dex\" movement in multiple myeloma care.

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\"Dr. Banerjee's work exemplifies the best of innovation and collaboration,\" noted Jay Hydren, HealthTree Senior Director of Research. \"His efficient research methods and targeted use of data sets have helped advance treatment standards and improve patient quality of life.\"
\n

The foundation also recognized several distinguished researchers with HealthTree Research Impact Awards for their outstanding contributions using the HealthTree Cure Hub^® Registry:

Dr. Urvi Shah (Memorial Sloan Kettering) for studies on diet, supplement use habits, and psychosocial aspects of blood cancer
Drs. Morie Gertz and Nadine Abdallah (Mayo Clinic) for research on delayed AL amyloidosis diagnosis
Dr. Malek Ehasan (Roswell Park) for machine learning applications in myeloma care
Dr. Sikander Ailawadhi (Mayo Clinic) for work on clinical trial awareness among multiple myeloma patients
Dr. Craig Hofmeister (Emory) and Dr. Karen Sweiss (UI Cancer Center) for research on pain management and the use of opioids
Dr. Manni Mohyuddin (Huntsman Cancer Institute) for studies on patient preferences in myeloma care

HealthTree Real-World Data Awards

A special recognition was given to researchers whose work using HealthTree's Real-World Data was accepted for presentation at ASH 2024. These recipients demonstrated the powerful impact of real-world data in advancing scientific discovery:

Dr. Malek Ehasan (Roswell Park Comprehensive Cancer Center)
Drs. Morie Gertz and Nadine Abdallah (Mayo Clinic)
Dr. Craig Hofmeister and Dr. Karen Sweiss (University of Illinois)
Dr. Sikander Ailawadhi (Mayo Clinic)
Dr. Rahul Banerjee (Fred Hutch Cancer Center)
Dr. Manni Mohyuddin (Huntsman Cancer Institute)

$\"\"$

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\"These researchers demonstrate the incredible potential of real-world data to transform blood cancer research and treatment,\" said Jenny Ahlstrom, CEO and Founder of HealthTree Foundation. \"Their work brings us closer to our mission of finding cures through innovative research and collaboration.\"
\n

The awards ceremony highlighted the growing impact of HealthTree Cure Hub^® Registry, which now includes data from over 10,000 multiple myeloma patients and is expanding to lymphoma, leukemia, and myeloproliferative neoplasms, enabling vital research that advances patient care and accelerates the path to cures.

Are you a researcher? Click below to learn more about HealthTree's research and how to partner with us:

Visit HealthTree Research

!AD!

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Unite for a Cause: Join Us in the Berkshires!

Are you a blood cancer patient, caregiver, or supporter looking to make a significant impact while challenging yourself in a stunning natural setting? We invite you to participate in the HealthTree Challenge: Hike and Wellness event, happening in the beautiful Berkshires of Massachusetts from October 23-25, 2025.

This event is specially designed to combine physical endurance, wellness, and community support while supporting blood cancer research.

With a limited number of spots available, we encourage you to apply early to secure your place. Learn more about the event details and registration below.

A Weekend of Wellness and Resilience

This unique event isn't just a hike; it's a retreat dedicated to overcoming obstacles, building resilience, and creating lasting impacts. As a participant, you’ll engage in:

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Wellness Activities: Enjoy expert-led sessions that nurture your mind and body for a comprehensive health approach. These activities include meditation, yoga, skill building, healthy eating, and stress management techniques.
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Community Connection: Meet and bond with other individuals who are passionate about supporting blood cancer patients and their families.
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Scenic Endurance Hike: Challenge your limits with a trek across the breathtaking Berkshire landscapes. Multiple trail options are available. To help you get ready, HealthTree provides an optional 12-week training program.
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Your Fundraising Impact

By joining the HealthTree Challenge, you commit to raising $1,500, which will directly contribute to vital research and resources for blood cancer patients. This fundraising effort is pivotal in providing help where it is most needed.

To aid you in these efforts, you’ll receive comprehensive fundraising support to help you reach—and possibly exceed—your financial goal. Our team is here to guide and support you every step of the way!

Join Our Community

This event is designed for a limited group of 50 dedicated individuals ready to make a difference. Whether you are a survivor, a caregiver, or a supporter, your participation will turn strength into action. This is more than just a hike; it's a statement of solidarity and a commitment to a cause that affects so many lives.

Ready to Sign Up?

Click the button below to register today and join us in making a difference for the blood cancer community. We can’t wait to welcome you to the Berkshires this October for an impactful weekend!

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We are excited to announce the launch of the HealthTree Regional Cure Teams—an opportunity for patients, caregivers, and passionate individuals to volunteer and make a difference in their communities.

With Cure Teams, you can join a network of like-minded people who share a common goal: contributing to a cure for blood cancer while creating meaningful connections.

What Are HealthTree Regional Cure Teams?

HealthTree Regional Cure Teams are volunteer-driven groups focused on making an impact locally. Each team is tailored to the specific needs, challenges, and resources of its region.

The Cure Teams will be divided into the following regions:

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Pacific
Rocky Mountain
Midwest
Southwest
Northeast
Southeast

No matter where you live, there’s a Cure Team for you.

How You Can Make a Difference

As a member of a HealthTree Regional Cure Team, you’ll have the chance to contribute in meaningful ways—big or small, every effort counts.

Grace, from the Pacific region, hosted her own fundraiser for HealthTree. Her friends and family gathered to celebrate her and contribute financially to blood cancer research.

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Here are examples of what you could do as a Cure Team member:

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Spread Awareness: Share HealthTree’s resources with your local community to empower others with the knowledge and tools they need.
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Expand the Cure Hub® Community: Invite local patients and caregivers to join HealthTree Cure Hub® Registry, a groundbreaking tool that unites patients, researchers, and clinical data to work toward a cure.
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Support Fundraising Efforts: Organize your own fundraiser or lend a hand in ongoing efforts in your region. Every dollar raised directly supports critical blood cancer research and patient initiatives.
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Connect with Others: Join outreach efforts to support Black, Hispanic, and rural patients who often face barriers in accessing adequate care and resources.
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Represent HealthTree: Attend local health events as an ambassador, helping to build awareness and create impactful partnerships.
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Join a Cure Team

This is an opportunity to contribute to something meaningful while working alongside a community that’s as driven as you are.

!AD!

Program Manager, Taryn Placko, shares more about cure teams below:

Do you have questions? Send an email to cureteams@healthtree.org or text/call +1 800 709 1113.

Written in collaboration with Sofia Capdevila

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HealthTree Foundation creates innovative tools that save lives. Join us on May 2 to learn more about HealthTree and HealthTree Cure Hub – a powerful, free tool that helps you manage your disease and contribute to cures.

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Dr. Ehsan Malek from Roswell Park Comprehensive Cancer Center and Dr. Krishna Ghimire from Upstate Cancer Center will be on hand to talk about their work in myeloma and blood cancers, new ways patients can participate in research, and answer your questions.

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There is no cost to attend. Registration, parking, and a light dinner are free. This meeting is open to patients with multiple myeloma, lymphoma, leukemia, and MPN.

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Why Attend?

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Learn all the ways HealthTree Cure Hub technology works for you:

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Meeting Details

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Meeting date: Thursday, May 2nd, 2024 at 5:30 PM
Location: Upstate Cancer Center, 1st floor conference room C1076 A/B/C on
Registration, parking, and a light dinner are free
Please bring your laptop and any necessary passwords to open or use your computer

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Questions?

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For questions about registration, contact us at +1-800-709-1113 or support@healthtree.org.

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For all other questions, contact curetour@healthtree.org.

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Thank you for your continued support and dedication to our cause. We look forward to seeing you at the HealthTree Cure Tour event!

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On October 23rd, hundreds of members of our community gathered to celebrate the launch of HealthTree 2.0. The energy was palpable and the overall feeling of the night was one of hope for the future. The Launch marked HealthTree’s laser focus on driving research to cure blood cancer and HealthTree’s expansion into over 40 additional blood cancers.

\n\n

Check out the pre-roll to our event here to learn more about HealthTree Foundations, its key members, and how our mission and purpose are leading to an CMML cure.

\n\n

The rest of the night was filled with powerful messages and exciting news of progress.

\n\n

See highlights from the night here:

\n\n

Attendees learned about HealthTree’s unique model, innovative technology and plans to build six regional communities across the countries.

\n\n

Keynote speakers included Fred Appelbaum, MD, Executive Vice President at Fred Hutch Cancer Center and author of Living Medicine, Rafael Fonseca, MD, Chief Innovation Officer at Mayo Clinic, and Jeffrey Wolf, MD, Myeloma Director at UCSF.

\n\n

The event was live streamed from Deer Valley, Utah where HealthTree hosted some of the country's most prestigious partners and supporters who shared insights on how together we will accelerate a cure.

\n\n

The event was inspirational, educational, and brought hope to all patients and their supporters who viewed the event.

\n\n

We encourage all patients and caregivers who have questions about the future of a cure, or who are currently struggling with their disease, and/or want to learn more about how HealthTree provides priceless information and experiences to the CMML and blood cancer community to view the videos above to learn more about this special, groundbreaking event.

\n","language":"EN","metaDescription":"In case you missed it, or you want to review, HealthTree has launched into other diseases in search for blood cancer cures.","metaTitle":"Recapping the HealthTree 2.0 Launch","migratedPendingGlobalCategories":true,"migratedReason":"global-community","migratedReason2":"fix global-community categories","oldAuthor":{"_type":"DocumentReference","path":"apps/community/authors/cOnyeAHAVZCc55OnuPi5"},"oldCategory":{"_type":"DocumentReference","path":"apps/community/categories/5439msnaQgjtgUsVVug3"},"publishedAt":{"_type":"Date","value":"Mon Nov 20 2023 06:00:00 GMT+0000 (Coordinated Universal Time)"},"seoKeywords":"healthtree foundation, healthtree for CMML, CMML patient advocacy, blood cancer patient advocacy","slug":"healthtree-2-recap-cmml","status":"ACTIVE","title":"Recapping the HealthTree 2.0 Launch","updatedAt":{"_type":"Date","value":"Thu Apr 25 2024 18:37:44 GMT+0000 (Coordinated Universal Time)"}},"included":{"category":{"data":{"createdAt":{"_type":"Date","value":"Thu Jul 07 2022 16:35:26 GMT+0000 (Coordinated Universal Time)"},"disease":{"_type":"DocumentReference","path":"diseases/GxAhXAnh3drV4xY5Vf3A"},"diseases":[{"_type":"DocumentReference","path":"diseases/GxAhXAnh3drV4xY5Vf3A"},{"_type":"DocumentReference","path":"diseases/WCJo8IouncjDW6exT1YS"},{"_type":"DocumentReference","path":"diseases/cll"},{"_type":"DocumentReference","path":"diseases/t8f3E99OdM9XZe1d1ASM"},{"_type":"DocumentReference","path":"diseases/eBIxYtdHAYhTTs5L9bcC"},{"_type":"DocumentReference","path":"diseases/EkjGB5kileTKP2vnTWhV"},{"_type":"DocumentReference","path":"diseases/WNjIFmDibXhTFneCh4dG"},{"_type":"DocumentReference","path":"diseases/leukemia"},{"_type":"DocumentReference","path":"diseases/E7FvorVuNJjGzy9wH7fy"},{"_type":"DocumentReference","path":"diseases/chronic-myelomonocytic-leukemia"},{"_type":"DocumentReference","path":"diseases/hodgkin-lymphoma"},{"_type":"DocumentReference","path":"diseases/non-hodgkins-lymphoma"},{"_type":"DocumentReference","path":"diseases/lymphoma"},{"_type":"DocumentReference","path":"diseases/mantle-cell-lyphoma"},{"_type":"DocumentReference","path":"diseases/lymphoblastic-lymphoma"},{"_type":"DocumentReference","path":"diseases/tDYO4O8HTJT5dAHT6xis"},{"_type":"DocumentReference","path":"diseases/essential-thrombocythemia"}],"migratedReason":"global-community","migratedReason2":"fix global-community categories","migratedSlug":true,"oldSlug":"healthtree","sectionConfig":{"news":{"description":"Our HealthTree Programs articles highlight the programs, events, and updates of the HealthTree Foundation.","metaDescription":"These articles highlight the programs, events, and updates of the HealthTree Foundation.","metaTitle":"HealthTree Programs - HealthTree Foundation","order":8,"tileOrder":6,"type":"SMALL_TILE"}},"sections":["NEWS"],"slug":"healthtree-programs","status":"ACTIVE","title":"HealthTree Programs","updatedAt":{"_type":"Date","value":"Thu Apr 25 2024 18:37:52 GMT+0000 (Coordinated Universal Time)"}},"included":{},"ref":{"_type":"DocumentReference","path":"apps/community/categories/WSTraX4hOKp92asdiTHa"},"snapshot":{"exists":true,"id":"WSTraX4hOKp92asdiTHa","ref":{"_type":"DocumentReference","path":"apps/community/categories/WSTraX4hOKp92asdiTHa"}}}},"ref":{"_type":"DocumentReference","path":"apps/community/articles/42QBukh6qfzUQkekn0Dl"},"snapshot":{"exists":true,"id":"42QBukh6qfzUQkekn0Dl","ref":{"_type":"DocumentReference","path":"apps/community/articles/42QBukh6qfzUQkekn0Dl"}}},{"data":{"author":{"_type":"DocumentReference","path":"apps/community/authors/s6tTUs3C9i1oJP7fJj9i"},"categories":[{"_type":"DocumentReference","path":"apps/community/articleCategories/kkZg6NpGR0LvLL1luJXx"}],"category":{"_type":"DocumentReference","path":"apps/community/categories/WSTraX4hOKp92asdiTHa"},"createdAt":{"_type":"Date","value":"Thu Jan 18 2024 17:29:11 GMT+0000 (Coordinated Universal Time)"},"disease":{"_type":"DocumentReference","path":"diseases/chronic-myelomonocytic-leukemia"},"diseases":[{"_type":"DocumentReference","path":"diseases/chronic-myelomonocytic-leukemia"}],"headerImageUrl":"https://firebasestorage.googleapis.com/v0/b/healthtree-production.appspot.com/o/gallery%2Fpublic%2FPillar%20three%20edited_d3358199-7961-4ac2-ba27-3a6d8a643139.jpg?alt=media","htmlContent":"

We've recently highlighted both Pillar One and Pillar Two of the new and improved HealthTree model on our website.

\n\n

These pillars, targeted to help educate and connect the CMML community, are essential as they build empowered, trusting relationships with communities that are then ready and willing to contribute toward a cure.

\n\n

Today, we focus on the third and final pillar that makes up the HealthTree Model: a Powerful Patient Data Portal.

\n\n

Our data patient portal, HealthTree Cure Hub, is designed to help patients and caregivers give back by connecting their medical data in a private, secure way. Researchers can analyze this anonymous data to come up with real-world solutions to complex CMML issues.

\n\n

Patients are also invited to participate in researcher-led studies and surveys to further key CMML research.

\n\n

The Purpose of a Powerful Patient Data Portal within HealthTree’s Model

\n\n

HealthTree Cure Hub, though technically "one program" within the foundation, consists of many easy-to-use, everyday tools that help you navigate your CMML and, at the same time, accelerate a CMML cure.

\n\n

When you're first diagnosed, it's hard to trust the multitude of information that's coming at you. That's where Pillar One, as mentioned before, comes into play because it helps organize, personalize, and simplify your CMML education. Pillar Two allows educated patients to become connected with one another and their communities. Pillar Three, HealthTree Cure Hub, gives patients (and care partners) a chance to give back.

\n\n

How does HealthTree Cure Hub get us to a CMML cure? It facilitates research! Patients and CMML investigators have pressing health questions and we created Cure Hub to answer those critical medical questions today. Through HealthTree Cure Hub, we will run queries (studies and surveys) led by top CMML investigators.

\n\n

Patients will have the chance to participate in these necessary studies and surveys, giving the researchers the ability to analyze the anonymized data to find the answers they are looking for.

\n\n

Because we will have the ability to access so many patients, we are able to cut recruiting time and money in half. Researchers have access to anonymized, validated data instead of spending a fortune in time and money trying to collect a patient data subset on their own.

\n\n

Doctors (oncologists and specialists alike) often complain they don’t have access to the patient’s complete health story, but Cure Hub allows doctors and patients to be on the same page about the patient’s health profile. Researchers believe a cure will come after understanding the full picture of the patient’s health history compared to others like them.

\n\n

HealthTree Programs within HealthTree Cure Hub

\n\n

HealthTree Cure Hub consists of many patient-friendly tools that help you manage your CMML.

\n\n

Track Your CMML Labs

\n\n

In Cure Hub, you can track all your CMML labs in a single place, so you don’t have to create or maintain a separate spreadsheet.

\n\n

Clinical Trial Finder (Coming Soon with Personalization!)

\n\n

HealthTree Cure Hub can currently search through hundreds of open CMML clinical trials. Enhanced personalization is coming shortly to help you narrow the list down to only those clinical trials you are eligible to join.

\n\n

CMML Twin Machine

\n\n

As our CMML Cure Hub database grows, you will be able to find and connect with patients who have similar experiences or genetics using our twin machine technology.

\n\n

Side Effect Solutions

\n\n

You can also use our Side Effect Solutions Tool where you can see hundreds of side effects and thousands of crowd-sourced solutions provided by patients. Learn from your peers to see what worked and what didn’t to manage the most common CMML side effects.

\n\n

Surveys and Studies (more surveys coming soon)

\n\n

Here you are be able to contribute your answers to critical questions CMML patients and researchers are asking today to help us drive faster to a CMML cure. In this section, you will soon find a variety of surveys and studies led by top CMML experts that you can participate in.

\n\n

To participate in these amazing features and get the full advantage from them, make sure that you connect your medical records. This is a secure and private connection, and your personal data will never be sold/shared without being completely anonymized.

\n\n

If you need help accessing any of these features, or connecting your medical records, or have questions in general about our research portal, contact our Patient Experience Team.

\n\n

Invitation to Participate in the Future of CMML

\n\n

At HealthTree we believe no one should have to face CMML alone. We encourage you to sign up for a HealthTree Cure Hub account to investigate all the tools and features provided to help you make the best CMML decisions possible.

\n\n

\n","language":"EN","metaDescription":"HealthTree Foundation discusses its new and improved model to help patients and caregivers with CMML find support and accelerate a cure.","metaTitle":"A Powerful Patient Data Portal ","migratedPendingGlobalCategories":true,"migratedReason":"global-community","migratedReason2":"fix global-community categories","oldCategory":{"_type":"DocumentReference","path":"apps/community/categories/5439msnaQgjtgUsVVug3"},"publishedAt":{"_type":"Date","value":"Wed Oct 04 2023 05:00:00 GMT+0000 (Coordinated Universal Time)"},"seoKeywords":"healthtree foundation, healthtree for cmml, healthtree, cmml, chronic myelomonocytic leukemia, leukemia support, cmml advocacy, living with cmml, leukemia support group, cmml support group","slug":"healthtree-pillar-3-cmml","status":"ACTIVE","title":"HealthTree Foundation Pillar Three: A Powerful Patient Data Portal ","updatedAt":{"_type":"Date","value":"Thu Apr 25 2024 18:37:45 GMT+0000 (Coordinated Universal Time)"}},"included":{"category":{"data":{"createdAt":{"_type":"Date","value":"Thu Jul 07 2022 16:35:26 GMT+0000 (Coordinated Universal Time)"},"disease":{"_type":"DocumentReference","path":"diseases/GxAhXAnh3drV4xY5Vf3A"},"diseases":[{"_type":"DocumentReference","path":"diseases/GxAhXAnh3drV4xY5Vf3A"},{"_type":"DocumentReference","path":"diseases/WCJo8IouncjDW6exT1YS"},{"_type":"DocumentReference","path":"diseases/cll"},{"_type":"DocumentReference","path":"diseases/t8f3E99OdM9XZe1d1ASM"},{"_type":"DocumentReference","path":"diseases/eBIxYtdHAYhTTs5L9bcC"},{"_type":"DocumentReference","path":"diseases/EkjGB5kileTKP2vnTWhV"},{"_type":"DocumentReference","path":"diseases/WNjIFmDibXhTFneCh4dG"},{"_type":"DocumentReference","path":"diseases/leukemia"},{"_type":"DocumentReference","path":"diseases/E7FvorVuNJjGzy9wH7fy"},{"_type":"DocumentReference","path":"diseases/chronic-myelomonocytic-leukemia"},{"_type":"DocumentReference","path":"diseases/hodgkin-lymphoma"},{"_type":"DocumentReference","path":"diseases/non-hodgkins-lymphoma"},{"_type":"DocumentReference","path":"diseases/lymphoma"},{"_type":"DocumentReference","path":"diseases/mantle-cell-lyphoma"},{"_type":"DocumentReference","path":"diseases/lymphoblastic-lymphoma"},{"_type":"DocumentReference","path":"diseases/tDYO4O8HTJT5dAHT6xis"},{"_type":"DocumentReference","path":"diseases/essential-thrombocythemia"}],"migratedReason":"global-community","migratedReason2":"fix global-community categories","migratedSlug":true,"oldSlug":"healthtree","sectionConfig":{"news":{"description":"Our HealthTree Programs articles highlight the programs, events, and updates of the HealthTree Foundation.","metaDescription":"These articles highlight the programs, events, and updates of the HealthTree Foundation.","metaTitle":"HealthTree Programs - HealthTree Foundation","order":8,"tileOrder":6,"type":"SMALL_TILE"}},"sections":["NEWS"],"slug":"healthtree-programs","status":"ACTIVE","title":"HealthTree Programs","updatedAt":{"_type":"Date","value":"Thu Apr 25 2024 18:37:52 GMT+0000 (Coordinated Universal Time)"}},"included":{},"ref":{"_type":"DocumentReference","path":"apps/community/categories/WSTraX4hOKp92asdiTHa"},"snapshot":{"exists":true,"id":"WSTraX4hOKp92asdiTHa","ref":{"_type":"DocumentReference","path":"apps/community/categories/WSTraX4hOKp92asdiTHa"}}}},"ref":{"_type":"DocumentReference","path":"apps/community/articles/rgt4ORlLyozMYQW94zqO"},"snapshot":{"exists":true,"id":"rgt4ORlLyozMYQW94zqO","ref":{"_type":"DocumentReference","path":"apps/community/articles/rgt4ORlLyozMYQW94zqO"}}},{"data":{"author":{"_type":"DocumentReference","path":"apps/community/authors/s6tTUs3C9i1oJP7fJj9i"},"categories":[{"_type":"DocumentReference","path":"apps/community/articleCategories/CzoXEaVTc5GoHbBHGxEH"}],"category":{"_type":"DocumentReference","path":"apps/community/categories/WSTraX4hOKp92asdiTHa"},"createdAt":{"_type":"Date","value":"Tue Oct 17 2023 00:12:16 GMT+0000 (Coordinated Universal Time)"},"disease":{"_type":"DocumentReference","path":"diseases/leukemia"},"diseases":[{"_type":"DocumentReference","path":"diseases/leukemia"}],"headerImageUrl":"https://firebasestorage.googleapis.com/v0/b/healthtree-production.appspot.com/o/gallery%2Fpublic%2FPillar%20three%20edited_d3358199-7961-4ac2-ba27-3a6d8a643139.jpg?alt=media","htmlContent":"

We've recently highlighted both Pillar One and Pillar Two of the new and improved HealthTree model on our website.

These pillars, targeted to help educate and connect the leukemia community, are essential as they build empowered, trusting relationships with communities that are then ready and willing to contribute toward a cure.

Today, we focus on the third and final pillar that makes up the HealthTree Model: a Powerful Patient Data Portal.

Patients are also invited to participate in researcher-led studies and surveys to further key leukemia research.

The Purpose of a Powerful Patient Data Portal within HealthTree’s Model

HealthTree Cure Hub, though technically \"one program\" within the foundation, consists of many easy-to-use, everyday tools that help you navigate your leukemia and, at the same time, accelerate a leukemia cure.

When you're first diagnosed, it's hard to trust the multitude of information that's coming at you. That's where Pillar One, as mentioned before, comes into play because it helps organize, personalize, and simplify your leukemia education. Pillar Two allows educated patients to become connected with one another and their communities. Pillar Three, HealthTree Cure Hub, gives patients (and care partners) a chance to give back.

How does HealthTree Cure Hub get us to a leukemia cure? It facilitates research! Patients and leukemia investigators have pressing health questions and we created Cure Hub to answer those critical medical questions today. Through HealthTree Cure Hub, we will run queries (studies and surveys) led by top leukemia investigators.

Patients will have the chance to participate in these necessary studies and surveys, giving the researchers the ability to analyze the anonymized data to find the answers they are looking for.

HealthTree Programs within HealthTree Cure Hub

HealthTree Cure Hub consists of many patient-friendly tools that help you manage your leukemia.

Track Your Leukemia Labs

In Cure Hub, you can track all your leukemia labs in a single place, so you don’t have to create or maintain a separate spreadsheet.

Clinical Trial Finder (Coming Soon with Personalization!)

HealthTree Cure Hub can currently search through hundreds of open leukemia clinical trials. Enhanced personalization is coming shortly to help you narrow the list down to only those clinical trials you are eligible to join.

Leukemia Twin Machine

As our leukemia Cure Hub database grows, you will be able to find and connect with patients who have similar experiences or genetics using our twin machine technology.

Side Effect Solutions

You can also use our Side Effect feature where you can see hundreds of side effects and thousands of crowd-sourced solutions provided by patients. Learn from your peers to see what worked and what didn’t to manage the most common leukemia side effects.

Surveys and Studies (coming soon)

Soon you will be able to contribute your answers to critical questions leukemia patients and researchers are asking today to help us drive faster to a leukemia cure. In this section, you will soon find surveys and studies led by top leukemia experts that you can participate in.

If you need help accessing any of these features, or connecting your medical records, or have questions in general about our research portal, contact our Patient Experience Team.

Invitation to Participate in the Future of Leukemia

At HealthTree we believe no one should have to face leukemia alone. We encourage you to sign up for a HealthTree Cure Hub account to investigate all the tools and features provided to help you make the best leukemia decisions possible.

If you'd like to be notified when our coming soon programs will be available, sign up for our newsletter. We send biweekly snapshots of all of our recently published articles, new program releases and announcements of upcoming events to everyone who signs up!

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If you or a loved one is navigating a blood cancer diagnosis, understanding how ROR1-targeted therapies work—and whether they could apply to your specific cancer type—can help you make more informed treatment decisions.

Main points:

ROR1 is a receptor found on the surface of cancer cells, rarely present in healthy adult cells, making it a promising treatment target for various blood cancers.
Early studies show that therapies targeting ROR1—such as CAR T-cell therapy, monoclonal antibodies, and small molecule inhibitors—may be effective in certain blood cancers like CLL and MCL.
Combining ROR1-targeted therapies with other treatments like venetoclax may help overcome drug resistance and improve patient outcomes.

In the sections below, continue reading to learn how these therapies are being tested, which blood cancers they may benefit most, and what early research is revealing about their potential to improve outcomes.

What Is ROR1 and Why Does It Matter for Blood Cancer Patients?

Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a protein that plays a role in early development. In adults, it's mostly inactive—but in several cancers, including chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL), ROR1 is turned back on and helps cancer cells grow and survive.

Because healthy adult tissues show little to no ROR1 activity, therapies that target it are less likely to harm normal cells. This makes ROR1 an appealing focus for developing more precise cancer treatments with fewer side effects.

For other blood cancers like multiple myeloma, acute myeloid leukemia (AML), and large B-cell lymphoma (LBCL), researchers have found ROR1-positive cancer cells in some patients. Early lab studies suggest that targeting ROR1 might help, but more research is needed to know how well these treatments work in real-life settings.

Clinical Trial Treatment Options That Target ROR1

Several types of therapies are being developed to block ROR1 and stop its cancer-supporting activity:

Monoclonal antibodies like cirmtuzumab designed to attach to ROR1 on cancer cells and block its signals. Early trials show this approach may be effective when combined with other treatments like venetoclax, which targets another cancer-promoting protein, BCL-2.
Small molecule inhibitors such as KAN0441571C are designed to enter cancer cells and shut down ROR1 from the inside. These are showing potential, especially in patients whose cancers resist standard therapies.
Antibody-drug conjugates (ADCs) like zilovertamab vedotin deliver chemotherapy directly to ROR1-positive cells, limiting damage to healthy cells. Click here to access a recruiting clinical trial for relapsed/refractory CLL, MCL, and follicular lymphoma patients.
CAR T-cell therapy that modifies a patient’s own immune cells to target ROR1-positive cancer cells. This approach is still in early testing.
Bispecific antibodies engineered to bring T-cells into close contact with cancer cells that express ROR1, helping the immune system do its job more effectively.

Why Combination Therapies Could Be the Future

One of the biggest challenges in blood cancer treatment is drug resistance—when cancer stops responding to treatment. Studies suggest that using a combination of therapies that target different pathways can reduce the risk of resistance.

For example, combining anti-ROR1 therapies with venetoclax may work better than either alone. This is especially important for people with high-risk or relapsed disease.

Bottom Line

If you’re living with CLL, MCL, or another ROR1-positive blood cancer, the development of ROR1-targeted therapies could eventually offer more effective and less toxic treatment options. While many of these therapies are still in clinical trials, early results are promising and could lead to new standard-of-care treatments in the future.

As research continues, it’s important to stay informed about clinical trials and emerging therapies. Talk to your doctor about whether any new treatment options may be appropriate for your specific situation.

Continue Exploring Advancements in Blood Cancer Treatments

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Source:

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Therapeutic advances in the targeting of ROR1 in hematological cancers
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Chronic myelomonocytic leukemia (CMML) is a blood cancer that occurs when the bone marrow makes too many monocytes, a type of white blood cell. The median age at diagnosis is 72 years, and it's more common in males than females. The most common medications used to treat CMML are: azacitidine (Vidaza), decitabine (Dacogen) and Inqovi (a combination of decitabine and cedazuridine). In CMML, it is common to have low counts of other blood cell types, such as platelets, which cause symptoms like the risk of bleeding, bruising and difficulty in healing wounds.

What Is Thrombocytopenia?

Thrombocytopenia (low platelet levels) and platelet dysfunction contribute to bleeding complications and can be life-threatening in severe cases. The most common symptoms are bleeding or bruising easily, even after minor injuries. Bleeding can occur inside the body, under the skin, or on the surface of the skin.

A New Medication To Improve Platelet Levels

Eltrombopag is a thrombopoietin receptor agonist that stimulates platelet production in the bone marrow. It is FDA approved for treatment of non-chemotherapy related disorders of low platelets like chronic immune thrombocytopenia (ITP).

Eltrombopag treats low platelet counts (thrombocytopenia) in CMML patients, as well as in adults and children with chronic immune thrombocytopenic purpura and severe aplastic anemia.

What Are the Side Effects of Eltrombopag?

Some side effects that may occur with this use of this treatment include:

Swelling of the face, hand, lower legs or feet
Fatigue
Chills
Cough
Fever
Nausea
Loss of appetite
Rash

A New Clinical Trial

A recent phase II trial enrolled 29 patients across 15 centers who had CMML and lower-risk disease. 11 patients had had at least one prior therapy, including steroids or intravenous immunoglobulins (IVIG).

This trial lasted for 12 weeks:

Patients received eltrombopag at a starting dose of 100 mg once daily, which was later changed to 50 mg/day.
The Dose was adjustable up to 300 mg/day.
Patients responding well could continue the treatment for up to 24 months.
This group had an overall survival rate of 47% and a two-year progression-free survival rate of 23%.

Conclusion

For those patients with CMML who are experiencing low platelet level complications, eltrombopag appears to be a new and effective treatment option when other lines of therapy have not been successful.

Become your best self advocate with HealthTree, we provide free resources to help you stay on top of your health!

Keep Learning More

Source:

Eltrombopag in chronic myelomonocytic leukemia with severe thrombocytopenia. A Groupe Francophone des Myélodysplasies (GFM) study

Vibecotamab is a type of antibody designed to target a specific protein called CD123, which is found in high levels on cancerous blood cells, especially those that affect the bone marrow’s ability to produce healthy blood cells (myeloid disorders). Because normal blood-forming cells have much lower levels of CD123, targeting this protein may help eliminate cancerous cells while sparing healthy ones.

A recent clinical study evaluated vibecotamab in patients with myeloid disorders who had limited treatment options. The study included patients with:

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Myelodysplastic syndrome (MDS) or chronic myelomonocytic leukemia (CMML) who have not responded to previous hypomethylating agents (azacitidine, decitabine).
\n
\n
Acute myeloid leukemia (AML) and in remission but with minimal residual disease (MRD) positive, meaning small amounts of leukemia cells remained in the body despite initial treatment.
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Key Study Findings

Myelodysplastic Syndrome and Chronic Myelomonocytic Leukemia

68% of patients showed improvement
63% achieved complete remission, meaning cancerous cells were no longer detectable in the bone marrow
It is particularly telling that all 3 patients with CMML achieved a complete remission
The median duration of response was 5.2 months
Patients in the study lived for about 10 months on average after starting the treatment

Acute Myeloid Leukemia

28% of patients achieved MRD negativity, meaning there were no detectable leukemia cells in the bone marrow.
All responses happened within the first treatment cycle.
Some patients maintained their remission for over two years, while others relapsed after stopping treatment.
There was no connection between how likely someone was to respond and the amount of CD123 expressed in cancer cells.

What’s the Safety Profile of Vibecotamab?

Vibecotamab was considered by the researchers to be generally well tolerated
The most common side effect was infusion-related reactions, which were mostly mild to moderate
No patients had to stop treatment due to severe side effects
Unlike some other treatments, vibecotamab caused minimal suppression of healthy blood cell production

What This Means for Patients

The study suggests that vibecotamab may be beneficial for patients with limited treatment options, especially those with high-risk or relapsed disease. The findings suggest continuing vibecotamab beyond the initial treatment period may help maintain remission.

If you or a loved one is exploring new treatment options, it may be helpful to discuss new agents being tested in clinical trials. They can assess whether a new treatment like vibecotamab may be appropriate based on your specific condition, previous treatments, and overall health.

If you want to read more about treatment advances and clinical trial updates, bookmark the HealthTree News page to browse our articles, written just for you!

Keep Reading More Articles

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Chronic myelomonocytic leukemia (CMML) begins when stem cells inside the bone marrow become abnormal. These abnormal cells produce immature white blood cells called blasts that continue to grow out of control and overcrowd normal blood cells like red blood cells, white blood cells, and platelets. CMML cells prevent healthy cells from developing into mature blood cells.

The CMML Special Initiative

CMML research aims to find effective, targeted therapies. “Targeted molecular therapy is a type of personalized medical therapy designed to treat cancer by interrupting unique molecular abnormalities that drive cancer growth.“ The Leukemia and Lymphoma Society plans to invest $13 million over five years in a special initiative that centers on targeted research to better understand CMML and provide essential, innovative treatment options.

One of the initiatives supported by the LLS's Special Initiative includes research from the University of Manchester in the United Kingdom led by Sam Butterworth, PhD, utilizing CCL2-drug conjugates to target and eliminate cancer cells. This project will run from November 1, 2023, to October 31, 2026.

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“CMML is a type of blood cancer with few effective treatments, and most patients have a poor prognosis. To address this problem, we have come up with a new approach using drugs that specifically attach to and eliminate the key cells responsible for the disease, more efficiently and accurately.”
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How CCL2 Works

CCL2 is a manufactured protein that is naturally absorbed by the body into its blood cells. It attaches to another protein, called CCR2, that is found on the outside of CMML cells. Healthy cells are not affected. Potent drugs can be delivered directly to cancerous cells through this avenue.

A New Approach

Currently, the lead drug being tested is CCL2-MM145, which has been shown to effectively kill cancer cells. “In our proposed project, we aim to speed up the development of CCL2-MM145 and bring it to CMML patients in clinical trials.” The goals of this initiative are to:

Better understand the unique characteristics of CMML cells and how they work
Uncover what makes these cells sensitive or resistant to CCL2-MM145
Learn about the beneficial and harmful effects of this new treatment
Determine how CCL2-MM145 may work in combination with other medications

Conclusion

This special initiative will offer essential treatment information and options for patients. Dr. Butterworth and his team possess extensive experience in developing new drugs, understanding CMML biology, and conducting clinical trials. You can explore other research funded by the initiative here. We hope this important initiative will expand treatment options for those with CMML.

Read More CMML News

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Cancer can be physically and emotionally demanding. For some people, this can also put them at risk of substance use. May is the Mental Health Awareness month and in this article we break down how substance use can affect cancer outcomes and explore how stigma can get in the way of care. You’ll also learn how treatment approaches can better support patients managing both cancer and substance use.

Substance Use Is Often Overlooked in Cancer Care

As cancer treatments improve, more patients are living longer. However, mental health and substance use care often remain under-prioritized in oncology. There is a link between substance use and cancer that cannot be overlooked as it goes both directions. Meaning that substance use can increase the risk of certain cancers, and a cancer diagnosis can also trigger or worsen substance use as patients manage pain or emotional distress.

In one study from JAMA Oncology involving over 6,000 adult cancer survivors, 3.83% had an active substance use disorder (SUD), with alcohol use disorder being the most common at 2.78%. This matters because patients with a SUD may receive less effective pain management and face more challenges following their cancer treatment plans. These difficulties can reduce quality of life and lower the chance of recovery.

Why Cancer and Substance Use Often Overlap

A cancer diagnosis often brings physical pain, stress, anxiety, and depression. To cope, some patients turn to alcohol, smoking, or other substances. Pain is commonly treated with opioids, which can be effective but also carry a risk of developing opioid use disorder (OUD).

To read more about opioid use and pain in cancer, visit this article of HealthTree Research findings by clicking the button below.

Managing Pain and Opioid Use for Myeloma Patients

Tobacco and alcohol are the most widely used substances that raise cancer risk.

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Tobacco causes about 30% of all cancer deaths, including 80% of lung cancer deaths. It is also linked to cancers of the mouth, throat, larynx, esophagus, stomach, colon, rectum, pancreas, liver, kidney, bladder, cervix, and even blood cancers. Tobacco not only increases the risk of cancer, but can also produce metabolic and circulation issues in the body that make receiving cancer treatment more challenging.
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Alcohol is responsible for about 3.5% of cancer deaths. The risk is proportional to the intake; higher amounts over long periods pose a higher risk. For women, heavy use means more than 4 drinks per day or 8 per week. For men, it’s more than 5 drinks per day or 15 per week. Alcohol is processed by the liver and can interfere with the metabolism of other cancer treatments, increase the risk of worse side effects, and, in some cases, inactivate the medication.
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These facts are important because quitting tobacco and reducing alcohol use, even after a cancer diagnosis, can still lower future cancer risks and improve health.

Other Substances That Can Complicate Cancer Treatment and Health

Aside from tobacco and alcohol, the following substances are also frequently seen among patients and can interfere with treatment:

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Cannabis or marijuana is a natural opioid that can be synthesized into CBD. It can be prescribed by a doctor and administered under controlled conditions. Medical-grade marijuana has strict sanitary regulations and can be beneficial for many people. There is a risk of fungal infection of the lungs associated with marijuana produced in unofficial or unsanitary settings. You can read more about safe uses of cannabis and its risks from the American Thoracic Society here.
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Anabolic steroids are the most commonly used drugs among athletes to improve physical performance and aesthetic appearance. These drugs interact with hormone cycles and can also have a negative impact on other organs such as the liver, the cardiovascular, central nervous, musculoskeletal, endocrine, and reproductive systems. It is important to note that anabolic steroids are different from the commonly used steroids in cancer treatments.
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Injection drugs, including heroin. These drugs are administered directly into the veins, and their use has risks besides addiction. They can cause vascular strokes, blood and tissue infections, and blood-transmitted diseases like hepatitis and HIV.
Prolonged use can affect the main veins, limiting the option for intravenous cancer medications or increasing the need for longer hospital stays to monitor its applications.
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Synthetic drugs, such as methamphetamine (“meth” or “crystal”) is associated with liver cancer and affects psychiatric and physical performance. It is a toxic chemical substance for multiple organs, including the heart, brain and other liver.
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Cocaine is a powder absorbed by the mucous membranes. While cocaine’s impact on cellular processes is not fully understood, researchers speculated that the drug might stimulate white blood cell activity and growth. This could potentially speed up the formation of genetic errors that could lead to cancer. Read more about the link of cocaine and cancer here.
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Each of these substances has harmful effects on the body in more than one way. For example, meth, heroine and cocaine are often mixed with other toxic chemicals and powders such as benzene, a known carcinogen. All of these substances, once they’ve entered the body, are processed for elimination, interfering with the proper functioning of organs and metabolism. When receiving cancer treatment, they can also interfere with the absorption and beneficial effects of the therapy.

Challenges in Coordinating Cancer and SUD Treatment

Treating cancer and SUD at the same time is complex. Some medications used to treat SUD, like buprenorphine or methadone, can interfere with cancer pain treatments or may be stopped when patients begin cancer care. Conversely, untreated SUD can make it harder to manage symptoms or keep up with appointments.

Patients taking naltrexone for alcohol use disorder may not be able to use certain cancer pain treatments that act on the same parts of the brain.

How Does Stigma Affect People With Substance Use Disorders?

Patients with past or current substance use may fear judgment or treatment changes if they disclose their use. This stigma can prevent honest conversations with their medical team. Feeling stigmatized can reduce the willingness of individuals with SUD to seek treatment.

Stigma remains a major barrier. Some healthcare providers are not trained to manage SUDs in cancer patients, leading to missed opportunities for care. Stigmatizing language and views can negatively influence health care provider perceptions of people with SUD, which can impact the care they provide.

Reducing Stigma and Improving Support

One approach that has shown great results is harm reduction. This means supporting patients in reducing risky behaviors without judgment. For example, rather than requiring someone to fully quit a substance, providers can offer ways to reduce harm while continuing cancer treatment. These can include safer use tips, mental health support, or starting SUD treatment when the patient is ready.

When harm reduction strategies are used with all patients, stigma can be reduced, and more people feel safe sharing their needs.

The way we name things impacts stigma around substance use disorders

There is a story behind every person, some wording perceived as popular, common or “harmless” can stigmatize people living with substance use disorders and prevent them for receiving the care they need. Reducing the stigma can start with simple things such as how we name things.

\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n

\n Preferred terms that do not stigmatize \n	\n Common terms that might stigmatize \n	\n Why change the language we use? \n
\n Person or patient *with* a: \n \n \n Substance use disorder \n \n \n Opioid use disorder \n \n \n Alcohol use disorder \n \n \n	\n Someone who is a/an: \n \n \n Junkie \n \n \n Addict \n \n \n Alcoholic \n \n \n	\n \n \n Person-first language \n \n \n Demonstrates a person “has” a problem, rather than “is” the problem \n \n \n Avoids negative associations or personal blame \n \n \n
\n \n \n Use (illicit substance) \n \n \n Misuse (prescription medications) \n \n \n	\n \n \n Substance abuse \n \n \n	\n \n \n “Abuse” is associated with negative judgments and punishment \n \n \n
\n \n \n Substance-free \n \n \n Expected/unexpected findings \n \n \n	\n \n \n Clean or dirty \n \n \n Positive/negative \n \n \n	\n \n \n Preferred terms are clinically accurate, non-stigmatizing \n \n \n
\n \n \n Recovery \n \n \n Remission \n \n \n Substance-free \n \n \n	\n \n \n Clean \n \n \n Sober \n \n \n	\n \n \n Preferred terms are clinically accurate and non-stigmatizing, similar to other medical conditions \n \n \n
\n \n \n Addiction \n \n \n	\n \n \n Habit \n \n \n Behavior \n \n \n	\n \n \n Substance use disorders are medical conditions \n \n \n “Habit” or “behavior” is inaccurate and implies control \n \n \n

Chart from Addiction in Patients With Cancer: Challenges and Opportunities

Sourced from National Institute on Drug Abuse (2020)

Moving Toward More Inclusive, Effective Cancer Care

Patients with cancer who also use substances deserve care that addresses all aspects of their health. Integrating addiction services into cancer centers and training oncology providers in harm reduction and substance use management are important next steps.

Better education, open communication, and a compassionate approach can improve outcomes and make sure no patient feels left behind. Substance use is not a failure; it’s a health issue that deserves understanding and treatment, especially during cancer care.

Stay tuned for more articles at the HealthTree News Site, where we publish a wide variety of topics, from conference updates to treatment innovations. Click the button below to keep reading more articles.

For more information and help for people with substance use disorders, you can visit the following assistance resources:

SAMHSA - Substance Abuse and Mental Health Services https://www.samhsa.gov/

Medication Assistance Therapy Care Clinic https://www.matcareclinics.com/

American Addiction Centers https://drugabuse.com/addiction/health-issues/cancer/

CDC Mental Health Resources https://www.cdc.gov/mental-health/caring/index.html#:~:text=Key%20points,to%20the%20nearest%20crisis%20center.

American Society of Addiction Medicine https://www.asam.org/

Start Your Recovery Organization https://startyourrecovery.org/experiences/co-occurring-disorders

Sources:

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As part of Mental Health Awareness Month, we’ll cover the causes, symptoms, and ways to manage brain-related side effects (difficulty thinking, headaches, etc.) that can happen from blood cancer treatment.

How Blood Cancer Treatments and Other Risk Factors May Impact Brain Function

Several factors can contribute to changes in brain function as a result of blood cancer treatment.

The treatments themselves, like chemotherapy, targeted therapy, radiation, and immunotherapy, can affect brain health by:

Crossing the barrier that protects your brain and directly impacting brain cells.
Triggering inflammation through immune system activation, which clouds brain function.
Remaining oxidative stress after treatment—caused by too many free radicals and not enough antioxidants—can damage healthy cells and trigger inflammation, affecting areas like the brain.

Factors That Increase Your Risk

Having certain health conditions before starting blood cancer treatment can raise the risk of brain-related side effects afterward. These include past cognitive issues (memory loss or trouble concentrating), anemia, mood disorders, chronic stress, hormone imbalances, high blood pressure, poor sleep, nutrient deficiencies, diabetes, systemic inflammation, or recurring infections, among others.

Even without treatment, cancer cells can increase inflammation in the body, which may dampen brain function.

What Do Symptoms Look Like?

The brain-related symptoms you may experience from certain blood cancer treatments may include:

Mild to moderate symptoms: trouble thinking clearly, confusion, fatigue, headaches
More serious issues (rare): difficulty speaking, tremors, seizures

These symptoms are sometimes called chemo brain, brain fog, cognitive impairment, neurological issues, or ICANS (immune effector cell-associated neurotoxicity syndrome). They can be short-term or last longer, but in either case, it is important to communicate with your care team if you are experiencing any of these symptoms for the first time or if they are worsening.

Tips for Recovery

If your brain-related symptoms aren’t improving over time, it’s important to get help. Here are some supportive strategies:

Consult with your blood cancer specialist: Talk to your doctor about ways to manage treatment side effects. For example, if you're experiencing headaches from a cancer therapy, ask what can help. They might recommend adding a headache-relief medication, adjusting the dose, or switching to a different treatment.
Nutrition support: Work with a registered dietitian to reduce inflammation and address nutrient gaps that directly impact brain health.
Visit a functional neurologist: See a functional neurologist who can pinpoint which areas of your brain need support and create a personalized therapy plan using targeted eye, hand, or balance exercises to help strengthen them. They may also suggest adding certain medications. This differs from a neurologist, who focuses mostly on medication to treat symptoms.
Mental health support: A licensed therapist can help you manage stress, anxiety, or trauma, and teach coping skills—like mindfulness and breathing techniques—that may reduce inflammation and improve your quality of life.
Lifestyle habits: Getting enough sleep, staying hydrated, exercising moderately, and eating nutrient-dense foods can support brain health.

Coping support: As you work to regain full cognitive function, tips like using a planner, taking frequent breaks, and doing brain-stimulating activities like puzzles or reading can help you support yourself during recovery.

Key Takeaways

Brain-related side effects from blood cancer treatments can occur and range from mild brain fog to more serious neurological issues.

While these changes can be influenced by the treatments themselves and pre-existing health conditions, there are several supportive strategies—from nutrition and functional neurological therapy to mental health care and lifestyle habits—that may help manage symptoms and promote recovery.

Even if side effects are expected, working closely with your care team is key to finding the right solutions for your cognitive health and overall well-being.

Discover Patient-Reported Side Effect Solutions

Want to share side effects you've experienced during treatment and what helped you manage them? Or curious about what’s worked for other patients? Use HealthTree’s patient-reported side effect solutions tool to learn and contribute below!

Access Side Effect Solutions

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Sources:

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On April 30, 2025, the United States Senate Appropriations Committee gathered for a hearing to discuss the future of federal funding for biomedical research in the United States. This session engaged a variety of voices from committee members, physicians, patients, caregivers, and advocates.

The Committee's main responsibility is to distribute federal funds that ensure that agencies like the FDA and the NIH have the necessary resources to drive scientific discoveries.

During the hearing, several experts and advocates testified, sharing their views on the benefits of federal funding and the urgent need for continued investment in life-saving research.

Federal Funds Advance Discovery, Save Lives, and Offer Hope

For many years, the U.S. has prioritized biomedical research, trained the next generation of scientists, and accelerated the pace of disease-curing discoveries. In the last 30 years, cancer death rates have dropped by 34%. These improvements are a direct result of federally funded programs devoted to cancer prevention, early detection, and advancing treatment options.

Maintaining strong federal support allows researchers to keep making progress, develop new treatments faster, and expand access to clinical trials for patients across the country.

There was strong support from both political parties in attendance for maintaining—and not cutting—federal funding for biomedical research. Legislators on both sides agree that continued federal support is essential for helping agencies like the NIH and FDA build on past achievements and address pressing health challenges.

Committee Chair Susan Collins (R-ME) pointed out that the FDA has approved over 600 cancer treatments because of years of government-supported research. Agencies will need continued funding to build on this progress.

Senator Tammy Baldwin (D-WI) spoke about the long-term impact of cutting biomedical research funding, highlighting that cuts will likely lead to fewer medical student acceptances and research positions, slowing progress in finding new treatments.

Emily Stenson, a pediatric cancer advocate, shared her daughter Charlie’s experience with cancer and emphasized that federal funding for clinical trial research has given her family the hope that she believes every family facing a cancer diagnosis deserves. “Hope gets you through the hardest days. Sometimes hope is all you have. We need to be able to provide that to all families”.

Investing in Innovation and Public Health

Continued investment in health agencies promises not only medical advancements but also helps grow the economy and improve public health outcomes. The Committee’s discussion shows a strong commitment to advancing biomedical research and ensuring that the United States remains a leader in scientific innovation.

How You Can Help Advance Research Through Your Experience

In addition to federal funding, progress in cancer research also depends heavily on understanding the real-world experiences of people living with blood cancer. Your voice can directly shape the future of blood cancer treatment.

By using tools like HealthTree Cure Hub®, you can complete short yet impactful surveys about your diagnosis, treatments, and side effects. This information helps speed up research and leads to more personalized and effective care.

Click the buttons below to access these simple surveys and to learn the results of past patient-accelerated research.

Make an Impact with Brief Blood Cancer Surveys

News Updates on Real-World Research

Sources:

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Combining venetoclax (VEN) with hypomethylating agents (HMAs) can improve response rates for patients with chronic myelomonocytic leukemia (CMML), but it does not improve survival. A multicenter analysis found that adding venetoclax to hypomethylating agents therapy improved response rates, including overall response rate (ORR) and complete remission (CR), but not overall survival.

Hypomethylating agents (HMAs) are the only approved therapy for CMML. Venetoclax has been added to HMAs to improve response rates and survival. HMAs are not known to prolong overall survival (OS) or stop the disease from progressing. Based on data from AML and MDS, venetoclax has been combined with HMAs to try to improve response rates.

What Is Venetoclax?

Venetoclax (Venclexta) is a targeted therapy known as a BCL-2 inhibitor. In certain types of cancer, there is an overproduction of a protein called BCL-2. This protein helps cancer cells survive by blocking programmed cell death. By attaching to the BCL-2 protein, venetoclax prevents it from doing its job, allowing cancer cells to undergo apoptosis as they normally would. This leads to the death of cancer cells and may make them more sensitive to other anti-cancer treatments. Venetoclax can work relatively quickly, with many patients seeing a reduction in disease burden within about one month of starting therapy.

Some of the possible side effects of venetoclax are: low white blood cell/red blood cell/platelet counts, nausea, diarrhea, fatigue, anemia and cough. It can cause serious side effects, such as tumor lysis syndrome and infections.

Combining Venetoclax with HMAs

In a multicenter analysis presented at the 66th annual American Society of Hematology (ASH), patients were given HMAs alone and also in combination with venetoclax. The median age of patients was 71 years old. 89 patients were treated. The hypomethylating agents used were azacitidine with decitabine.

The overall survival (OS) of patients was 25.1 months.
Overall response rate (ORR) for HMAs alone was 46% and 95% for those treated with venetoclax + HMAs combination.
A total of 29 patients went on to receive allogeneic stem cell transplant (alloSCT).
There was no significant overall survival difference between the HMA+ venetoclax combination versus HMAs alone (19.1 months versus 19.1 months).

Conclusion

Chronic myelomonocytic leukemia (CMML) is a rare blood cancer, most commonly diagnosed in older adults—typically between the ages of 73 and 75—and more often in men. In this study, most participants were considered high-risk. While combining venetoclax with hypomethylating agents (HMAs) led to higher response rates compared to HMAs alone, it did not result in longer overall survival. These findings highlight the need for continued research to discover more effective treatment options.

If you or a loved one is navigating CMML and want to stay informed about the latest treatments, studies, and research updates, be sure to follow our news site for ongoing coverage and insights.

VISIT HEALTHTREE CMML NEWS

Source:

Venetoclax (VEN) Improves Response Rates but Not Survival in Patients with Chronic Myelomonocytic Leukemia (CMML) Treated with Hypomethylating Agents (HMA): A Multicenter, Propensity Score Analysis

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If you've ever felt unseen, misunderstood, or dismissed because the chronic blood cancer you live with isn’t visible, you're not alone. This article offers validation, practical tools, and empowering ways to navigate the emotional weight of living with an invisible illness.

Messages Others May Be Telling You

After the initial shock of a diagnosis fades, many people with chronic blood cancer face ongoing frustration—especially when they hear, “But you don’t look sick.” Because the cancer isn’t immediately life-threatening or visible, those around them may downplay its seriousness, expecting life to continue as usual.

In The Myth of Normal, Dr. Gabor Maté notes that trauma impacts everyone differently. What may seem minor to onlookers can be something that has a major internal impact on the person experiencing it. This is especially true for people living with chronic blood cancer.

Many of the struggles are invisible: persistent fatigue, increased infection risk, anxiety associated with the uncertainty of cancer progression, and the financial stress of long-term care. Over time, these challenges can become overwhelming. And even when loved ones mean well, not feeling understood or validated can add to the emotional toll.

In her new book, The Big C ² - stories from the chronic side of cancer, Ruth Fein writes about Michele, who lives with chronic leukemia.

\n
Recently, two of her closest friends made comments that had Michele trying desperately to keep her raised eyebrows from freezing in place. “You are lucky you have never really felt bad,” is the paraphrase she remembers. “What?!?”
\n

\n
“Well, we always thought you looked great, so you must feel great,” they said when she finally had a heart-to-heart with them about how shocked she was by their comments.
\n

\n
“These were days that I couldn’t even fathom picking up the phone; I didn’t even want to get dressed or wash my hair... or get out of bed,” she recalls thinking. Then she was hit by the common denominator. She never explained, even to her besties, how badly she was feeling.
\n

Messages You May Be Telling Yourself

You might feel you need to push yourself to meet the expectations of others or based on how you want others to see you. While it can be difficult to feel your cancer is minimized by friends or family, you also don’t want to be treated as a cancer “victim” who is always needy. There is a natural desire to hold on to the life and identity you had before your diagnosis. Not fully accepting and sharing your new or changing reality is one way your mind may try to protect you.

One of the most helpful things you can do is find ways to focus on the parts of yourself that bring you joy and purpose while acknowledging the reality of your health and any related limitations.

For example, if you’re naturally social but feel isolated due to infection risks, talk to your doctor about preventative strategies that could help you safely reconnect with others.

Openly sharing your values, routines, and goals with your doctor can also help shape a care plan that better supports your day-to-day emotional well-being. And if you don’t feel truly heard by your care team, it might be time to look at other more supportive options.

You’ll find a list of specialists by blood cancer type at the end of this article. A trusted healthcare provider can make all the difference, along with a team that includes a social worker, mental health professional, or others who can help you integrate your physical and emotional health needs.

Setting You Up for Success

Building healthy coping strategies and surrounding yourself with supportive people who understand what you're going through is essential—especially when you are triggered by comments like, “You don’t look sick,” while you are struggling internally.

Finding support groups that include other patients with similar experiences may help validate your feelings. If you find it difficult to process your experiences or communicate your needs to others, working with a licensed therapist—either one-on-one or with family—can be incredibly helpful.

If you feel pressured by those around you to act as if nothing has changed since your diagnosis, symptoms, and treatments, it’s important to set clear boundaries. Let them know what support actually looks like for you. You can be both direct and kind. When loved ones are aware of strategies to help you feel more seen, understood, and empowered, they are more able to help you feel your best.

Below, we’ve included examples of responses you can say if someone says, “But you don’t look sick.”

Responding to “You Don’t Look Sick”

1. Acknowledge the good intent, but clarify the impact:

“I appreciate that, and I know you mean well, but comments like that can actually make me feel like a “cancer imposter” – like I’m not really going through this.”
“Thanks, I know it might seem like I’m okay on the outside, but it doesn’t reflect how I feel inside.”

2. Use “I” statements to express how it feels:

“I know I don’t look sick, and that’s actually one of the hardest parts—because I’m really struggling internally.”
“I’ve learned that appearances can be deceiving, even to myself sometimes.”

3. Gently educate if the moment feels right:

“It’s an invisible illness—things like fatigue, brain fog, and pain don’t always show up physically.”

4. Share more if they seem open; if not, protect your energy:

“If you’re curious, I’d be happy to share what it’s really like to live with this.”
Or simply: “Thanks,” and move on if that’s more comfortable at the time.

5. Validate your own experience:

You don’t have to justify how you look to others or yourself. While it poses emotional challenges not to look sick, it can also help you feel better about yourself, even while you don’t feel well on the inside.
When it comes to lengthy explanations, save your energy for people who truly matter—those who want to understand.

Bottom line: Use direct communication, not defensiveness. Assume good intent, but honor your truth. You can advocate for understanding without having to prove your pain.

Summary

Living with an invisible illness like chronic blood cancer comes with unique emotional and social challenges, but you don’t have to face them alone. By embracing your reality, setting healthy boundaries, and seeking support that validates you, you can reclaim a sense of control and connection.

Connect with a Chronic Blood Cancer Specialist

If you haven’t already, it’s important to connect with a specialist who focuses on your type of chronic blood cancer. They can offer the best care to improve both your quality and length of life, whether that involves active monitoring, access to the best FDA-approved treatments or clinical trials, or support for managing side effects.

To find a specialist, click the directory link below that matches your type of chronic blood cancer:

Chronic eosinophilic leukemia (CEL)
Chronic lymphocytic leukemia (CLL)/Small lymphocytic lymphoma (SLL)
Chronic myeloid leukemia (CML)
Chronic myelomonocytic leukemia (CMML)
Chronic neutrophilic leukemia (CNL)
Essential thrombocythemia
Follicular lymphoma
Multiple myeloma
Myelodysplastic syndromes (MDS)
Myelofibrosis
Polycythemia vera
Waldenstrom's macroglobulinemia

!AD!

Sources:

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It's no secret that the last two months have been very tumultuous. Layoffs in very important parts of government, as well as potential cuts in very useful and popular programs, are causing havoc in our stock market and living rooms across the country and, in fact, the world. In this article, we'll explore how these changes might affect your healthcare and what steps you can take to protect yourself.

I have decided to review how some of these issues can affect you, how you can be aware of changes that might affect you, and what you can possibly do to mitigate negative impacts on your healthcare. Additionally, I will provide you with sources where you can find timely and relevant information that can help you navigate the best you can.

Understanding Medicare and Medicaid Changes

The Current Situation

Some of the issues we have seen before, others we haven't, so it is yet to be seen how the latter will shake out. The House passes a budget resolution instructing the House Energy and Commerce Committee to reduce the federal deficit by at least $800 billion over the next 10 years. In the resolution, Medicaid is not mentioned directly; however, because Medicaid is E&C's jurisdiction, the cuts are expected to come from Medicaid. The Congressional Budget Office early confirms this.

What These Cuts Mean

Major cuts to Medicaid are the only way to meet the House's budget resolution requirements. There are many ways to cut Medicaid. And as states administer Medicaid, they would be left raising revenue or cutting spending. Cutting Medicaid would mean dropping coverage for some people, eliminating coverage of high-cost optional benefits such as prescription drugs, or cutting payment rates to health plans and providers.

State-by-State Impact

Different policies would have different implications for states, with policies such as a per capita cap having widespread effects across all states and policies such as cuts to the federal share of funding for the Affordable Care Act (ACA) expansion. As subsidies are automatically set to expire at the end of 2026, some changes may not be implemented before then.

Additional Policy Changes

The cost-cutting will disproportionately affect red and blue states that have expanded Medicaid. Additional Medicaid policies that may be implemented include: limiting supplemental payments to hospitals, which accounted for one-fifth of all spending on hospital care in 2023. These cuts could disproportionately affect the healthcare industry, with the consequences being larger in states with greater reliance on such payments. Again, those with expanded Medicaid, additional proposed changes to Medicaid include work requirements. Some states have already started trying to implement this. Some of the concerns patients may have are making too much money to qualify for Medicaid and too much for the Affordable Care Act.

Impact on Social Security and Healthcare Access

Social Security Processing Delays

Social Security is also in the crosshairs, though the President has said he won't touch it. There is precedent to say he might. However, reductions in the workforce at the Social Security Administration will put an additional strain on application processing. In December, the average wait time for a Social Security disability application processing was 255 days, with a 1.2 million application backlog. With a reduction in the workforce, that processing timeline is sure to be extended.

Assisting people with enrollment in Medicare Parts A and B, along with Part D prescription benefits, Social Security Disability Income, Supplemental Security Income (SSI), and Social Security Retirement income will also be impacted.

Tips for Disability Applications

If you are going to apply for Social Security Disability Benefits, consider working with an attorney. This will help to make sure your paperwork is in good order when you first apply, and reduce errors and wait times. Make sure you start as early as possible to reduce a lapse in income and coverage.

Rural Healthcare Concerns

For those who live in rural areas, the closing of many medical facilities has created difficulty in accessing care. The cost of travel to get medical treatment may become more expensive. Telehealth has been a saving grace for many people. Unfortunately, the extension of telehealth faces uncertainty in Congress.

Treatment Access and Clinical Trial Updates

Supply Chain Concerns

The cost of prescription drugs can increase with a supply shortage, particularly for medicines coming from China, India, the EU, Canada, and Mexico. In fact, the majority of active pharmaceutical ingredients come from other countries, 70% from China and India. If there are shortages, it could exacerbate the already existing shortage. Go to the FDA database to see which therapies are in short supply.

Impact on Clinical Trials

Medicine shortages can affect clinical trials by causing them to pause or shut down because they may not have enough of the treatment needed for the study. If you are in a clinical trial, the care team will update you about any shortages or delays.

Research and Trial Availability

The National Institutes of Health has recently lost researchers and funding. These can reduce the number of clinical trials that are started and completed. If you are concerned about your clinical trial, contact the study team or the trial sponsor for updates.

Taking Action

A lot is going on right now, and we may be processing this for quite a while. This is definitely not a time to ignore what is going on, as one or more of these issues may affect you directly.

What can you do? Be aware of what's happening. Start budgeting for additional costs if you can. Advocate! Send letters to your state representatives. Call them! They want to hear from their constituents; after all, they want to stay in office. And if they aren't serving those who elected them, staying in office becomes a major challenge.

Stay Connected and Informed

Join me for regular updates and guidance through our Financial Connect channel, our bi-monthly Q&As, and webinars. Together, we can navigate these challenges and ensure you have the support you need.

Join the Financial Support Group

Sources:

HealthTree Webinar: Navigating Financial Uncertainty: Proactive Tips for Blood Cancer Patients and Families. March 4, 2025
American Hospital Association. Feb 2025 Fact Sheet: Telehealth Waivers and ACA
KFF: The Math is Conclusive: Major Medicaid Cuts are the Only Way to Meet House Budget Resolution Requirements. Alice Burns, March 7, 2025
KFF: Workforce Reduction at Social Security Could Affect Medicare and Medicaid Coverage. Juliette Cubanski, March 3, 2025

If myeloma, lymphoma, or leukemia patients are referred to receive CAR T-cell therapy, what barriers are keeping them from receiving it?

Yannis Valtis, MD, a Chief Fellow at Memorial Sloan Kettering Cancer Center, led research efforts to evaluate these barriers. The study’s findings were discussed at the 2024 ASH conference.

Watch Dr. Valtis’ interview on barriers to CAR T-cell therapy below and continue reading for a summary of his important research.

6 Barriers to Receiving CAR T-Cell Therapy

Out of 400 blood cancer patients (myeloma, lymphoma, and leukemia) referred to receive CAR T-cell therapy, 44% of these patients ended up not getting the treatment.

What happened?

From Dr. Valtis’ research, the reasons patients did not receive CAR T-cell therapy included:

\n
Cancer Progressed Too Quickly:
\n
- \n
  CAR T-cell therapy made from a patient’s own T-cells takes several weeks to make. The top reason why patients didn’t receive the treatment was because the cancer progressed too quickly before the therapy was ready.
  \n
\n
\n
Treatment Shortage or No Clinical Trial Available:
\n
- \n
  The second reason patients didn’t receive their scheduled CAR T-cell therapy was that the treatments were not available or that patients couldn’t access the therapy in a clinical trial.
  \n
\n
\n
Concerns About Side Effects:
\n
- \n
  The third reason blood cancer patients didn’t receive CAR T-cell therapy was because either they or their doctor had concerns about side effects and decided to withdraw.
  \n
\n
\n
No Immediate Need for Therapy:
\n
- \n
  Some patients were referred when the cancer was stable or in remission, so they did not need the treatment.
  \n
\n
\n
Logistical Issues:
\n
- \n
  Many patients faced difficulties with logistical issues, such as needing to relocate or not having a caregiver.
  \n
\n
Other Reasons:\n
- \n
  A few patients and doctors were concerned about whether the treatment would work.
  \n
- Some patients could not receive the treatment due to manufacturing problems.
\n

Additional insights from the study mentioned that patients with lymphoma were more likely to receive the therapy than those with myeloma.

Also, Black patients were less likely to receive the treatment compared to White patients, even when considering their type of cancer.

Possible Solutions

To help more patients receive CAR T-cell therapy, possible improvements could include:

Early Referrals\n
- Referring patients earlier for CAR T-cell therapy could support enough preparation time for treatment before the cancer worsens.
\n
Faster Treatment Options\n
- Researchers are developing ready-to-use CAR T-cells, also known as “off-the-shelf” CAR T-cell therapy from donors. This could help remove the delay period for patients who need a fast turnaround.
\n
Improved Patient and Doctor Education\n
- More information could help patients and doctors decide sooner and understand the risks and benefits of CAR T-cell therapy.
\n
Addressing Racial Disparities\n
- Further studies are needed to understand and remove barriers that prevent Black patients from receiving CAR T-cell therapy.
\n

Conclusion

CAR T-cell therapy is a promising treatment for blood cancer patients, but not everyone who is referred can receive it. The most common barriers include the cancer progressing too fast, the treatment is not available, and concerns about side effects.

By referring patients earlier, developing “off-the-shelf” treatment options, educating about side effect management, and addressing logistical challenges, more patients could benefit from CAR T-cell therapy.

Morning and Afternoon Session: Chronic Lymphocytic Leukemia

Addressing Current Questions and Controversies in the Management of CLL – What Clinicians Want to Know

This session will focus on how specialists treat chronic lymphocytic leukemia (CLL). The faculty members will discuss the answers to questions such as:

\n
What are the latest relevant research findings for CLL?
\n
\n
The results of evidence-based treatment approaches
\n
\n
What are health professional’s perspectives on ongoing studies?
\n

In an upcoming article, we’ll cover the highlights of this session.

An Interactive Case-based Review of CLL: Experts Explore the Latest Evidence and Guideline Updates

Recent advancements in CLL include new treatment strategies, targeted therapies, and updated clinical guidelines. In this session, we’ll cover the most recent NCCN Guideline updates and innovative clinical approaches and highlight the most relevant discussions, expert recommendations, and comprehensive clinical data.

Crafting Custom Care in CLL: Guidance on Upfront and Sequential Treatment Decisions With Targeted and Immune-base Platforms

In this session, CLL experts will discuss practical insights into addressing key challenges in CLL treatment, from new therapies and strategies for relapsed/refractory CLL. The topics will include:

\n
Personalized selection of first-line continuous BTK inhibitors
\n
\n
Experience with BTKi-BCL2i combinations
\n
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Therapy involving non-covalent BTKi (ncBTKi) and CAR-T immunotherapy in relapsed or refractory CLL
\n
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Cutting-edge approaches such as next-gen BCL2 inhibitors, BTK degraders, BTKi, and bispecific antibodies for patients with multiple prior therapies.
\n

Late Afternoon Session: Acute Myeloid Leukemia and Acute Lymphocytic Leukemia

Addressing Current Questions and Controversies in AML Management - What Clinicians Want to Know

During this session centered on acute myeloid leukemia (AML), the areas of greatest interest from a survey completed by 50 general medical oncologists/hematologists, will be presented. This will include topics such as:

\n
Relevant research findings
\n
\n
The results of evidence-based treatment approaches
\n
\n
What do health professionals want to know about AML?
\n

Stay tuned so you know all the details of this session.

Medical Crossfire®: New Horizons in ALL—How The Experts Apply New Evidence From Adolescent & Young Adult to Adult Scenarios

This Medical Crossfire® session addresses the challenges health professionals face in keeping up with rapid advancements in acute lymphoblastic leukemia (ALL) care. Through case-based discussions, we will inform you about the discussion of practical strategies doctors use for integrating new therapies, how they overcome barriers to their implementation, and how they manage common side effects. We will also highlight details on recent evidence and real-world practices and how healthcare professionals align patient care approaches with expert insights.

Stay Tuned!

We’re excited to cover this important information for you so it’s comprehensive and so that you can stay updated on what can affect and benefit your life. Bookmark the link below to catch up on news about HealthTree’s conference coverage at ASH24.

HealthTree Conference Coverage

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If you or a loved one are battling a blood cancer like chronic myelomonocytic leukemia (CMML), it is important to understand the different aspects that may impact your journey to recovery, such as the type of insurance you have. Dr. Kingsley Nnawub of the University of Arkansas for Medical Sciences Northwest Regional Campus shared his research findings at the recent ASH 2023 conference. These findings demonstrate how the type of insurance a patient has impacts their survival outcomes and the quality of care they receive. Watch his interview or read the summary of his findings below.

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Dr. Nnawub's research focused on blood cancer patients in Arkansas, analyzing medical record data from 2013 to 2022. His team reviewed over 2,400 patients' records, assessing how different insurance types influenced their survival outcomes and the quality of care they received.

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Key Findings

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Insurance type matters: The study revealed that the type of insurance patients had was the most important factor affecting their survival. This includes Medicare, Medicaid, private insurance, military insurance, and those without insurance. Patients with private insurance fared better in terms of survival. They often had access to more comprehensive care options, especially after completing their main cancer treatments
Medicare and survival rates: Patients on Medicare, typically above 65 years of age, showed less favorable outcomes over five years compared to those with private insurance. This could be due to limited post-treatment care options and the presence of other health conditions like diabetes or heart disease
Age and comorbidities: While age and the presence of other health conditions did play a role in patient outcomes, they weren't as significant as the type of insurance in determining patient outcomes

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What Does This Mean for You?

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As a patient battling CMML, this information is invaluable. It highlights the need to understand your insurance policy and its limitations or advantages. Here are some ways this study can be useful to you:

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Advocating for better care: Knowing that insurance types can affect outcomes, you can advocate for the best possible care under your current plan
Exploring options: If possible, explore different insurance options that might offer more comprehensive coverage for your treatment needs
Informing decisions: Use this information when making decisions about your treatment plan. Discuss with your healthcare provider how your insurance might influence your care options

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Navigating Your Journey with Confidence

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The journey through CMML treatment can be complex and multifaceted. This study is a reminder that your insurance type is more than just a way to pay for treatment; it's a crucial element that can influence your overall care and prognosis. As you navigate this path, keep in mind the importance of understanding all aspects of your treatment, including insurance.

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Remember, you're not alone in this fight. Your healthcare team, including doctors, nurses, and patient advocates, can provide guidance and support. Don't hesitate to ask questions and seek the best possible care for your unique situation.

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In conclusion, Dr. Nnawub's study shares important insight about the critical role of insurance in cancer treatment outcomes. As a patient, being informed and proactive about your insurance can make a significant difference in your treatment journey. Stay empowered, and remember that every step you take is a step towards recovery and better health.

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Does a type of sugar called fructose impact cancer cells? Glucose, the main form of sugar in the blood, is known to be used by all cells, including cancer cells. Fructose is naturally found in certain fruits and vegetables but has also been increasingly added to food products over the last 50 years, notably as high-fructose corn syrup—an artificial mixture of fructose and glucose.

Researchers have been exploring whether fructose impacts specific types of solid-tumor cancer cells in mice. The findings of these studies offer new insights into how different sugars could affect cancer growth.

Oncology Registered Dietitian Shares Thoughts on Sugar and Cancer

Before examining these findings, it’s beneficial to understand some fundamental concepts about sugar and cancer, shared by Joan Elizondo, a registered dietitian specializing in oncology nutrition at the Huntsman Cancer Institute. During a webinar hosted by HealthTree, Elizondo explained:

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\"Foods containing any type of sugar or carbohydrate are broken down into glucose by the body. This glucose then pairs with insulin to enter our cells and provide them with energy. Excess energy gets stored for later use. While all cells utilize glucose, it does not necessarily mean that sugar causes cancer to spread or grow. Additionally, even without sugar or carbohydrate intake, the body can produce glucose from other sources like protein and fat. Thus, you cannot starve cancer cells of glucose without also starving your healthy cells.\"
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Elizondo also highlighted the link between added sugars and obesity, a known risk factor for cancer. By reducing intake of added sugars, one can decrease excess calorie consumption and maintain a healthier weight.

Reviewing Fructose’s Impact on Solid-Tumor Cancer Cells

Building on this knowledge, researchers specifically looked at how fructose affected melanoma, breast cancer, and cervical cancer cells in mice. They discovered that cancer cells cannot directly use fructose.

Instead, after fructose is metabolized in the liver, they use one of the byproducts—lysophosphatidylcholines (LPCs), a type of fat molecule— to build their outer membranes and grow. It is not yet known if this is how all cancer cells use fructose or only the ones in the study.

A significant aspect of the study involved blocking the protein KHK, which is responsible for breaking down fructose. This inhibition lowered the levels of the fat molecules or LPCs, thereby hindering the growth of cancer cells.

Contrary to what might be expected, feeding mice fructose supplements did not lead to weight gain or insulin resistance, which are commonly associated with increased cancer risk.

It's crucial to note that these findings are based on animal models, and the exact implications for humans are still to be determined. Further studies are planned to explore whether inhibiting KHK could slow cancer growth in humans without requiring dietary changes.

The researchers emphasized that this does not mean people should eliminate fructose from their diets but rather encourage moderation of fructose-containing foods in their natural forms, like fruits and vegetables.

An additional study that echoes the use of fructose in moderation studied people who ate it in excess. Excessive consumption of fructose, particularly in processed forms like high-fructose corn syrup, not only differs in how it’s metabolized from whole fruits and vegetables but can also increase inflammation, a known promoter of cancer growth. A notable finding was that this effect was observed more frequently in Black populations.

Understanding your risk status can help you take preventive measures. If you are concerned about ways to manage inflammation, please consult your doctor.

!AD!

Summary

Researchers have discovered that while certain solid tumor cancer cells cannot directly utilize fructose, they can use LPCs—fat molecules produced when fructose is metabolized in the liver—to construct their outer membranes.

Although these findings are based on animal studies and are preliminary, they advocate for moderation in fructose consumption, encouraging individuals to favor natural sources over processed forms like high-fructose corn syrup, which are metabolized differently.

This study not only highlights the unique ways fructose affects cancer cell metabolism but also suggests new avenues to restrict cancer cell growth, such as with KHK inhibitors.

Are you interested in helping researchers understand the correlation between diet and blood cancer? Click the button below to participate in our survey. Your answers are anonymous to researchers.

Take the Survey

Sources:

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What Is TET2?

Mutated TET2 Impact

How Are CMML And TET2 Connected?

Conclusion

You can keep learning with HealthTree's comprehensive updates on research news, conferences and more. Click the button below to browse our different article categories.

Read More CMML News

Source:

Gene-mutation pathway discovery paves way for targeted blood cancers therapies

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The Importance of Patient Perspectives in Clinical Trial Research

Research shows that Patient-Reported Outcomes (PROs) are often not well-reported in cancer clinical trials. PROs are data directly from patients about the effects of treatment, including physical symptoms, emotional responses, and overall well-being. A review of studies on solid tumors found that PROs and Health-Related Quality of Life are frequently underreported. Even when reported, these measures often fail to address long-term impacts. Given the serious nature of blood cancer and its potential to affect daily living and quality of life, it is especially important to consider PROs when studying the effectiveness of a treatment

Measuring Data in Clinical Trial Research

In clinical trials, researchers establish endpoints—measurable data that show how effective a treatment is. There are three main types of endpoints: primary, secondary, and exploratory.

Primary endpoints are outcomes that help to determine how safe and effective the treatment is. These endpoints typically address the main research hypothesis. Secondary endpoints provide additional information about a treatment's effects, often evaluating side effects or quality of life. Exploratory endpoints may reveal patterns or trends and help develop new hypotheses for future research.

Endpoints provide crucial information that guides treatment decisions and shapes the future of blood cancer research. A typical endpoint in blood cancer trials is survival, or whether the treatment helps a patient live longer.

Although PROs are Measured in Most Trials, They Are Not Always Reported

A recent study reviewed publications from eight leading oncology journals to examine how often patient-reported treatment impacts are collected during clinical trials and shared in journal articles. The study looked at 90 blood cancer clinical trials to determine whether PROs were used as an endpoint and whether that data was included in primary trial publications.

Out of the 90 clinical trials, 66 included PROs as an endpoint. In these trials, PROs were a primary endpoint in one trial, a secondary endpoint in 50 trials, and an exploratory endpoint in 15 trials.

However, although PRO data was collected in the majority of studies, fewer than half of these studies reported the data in the primary publication. Furthermore, the PRO data that was published showed either improvement or no change in symptoms, with no reports of worsening symptoms. This raises the concern that worsening symptoms may be underreported in clinical trial publications.

HealthTree is Dedicated to Ensuring Patient Perspectives Are Shared

PRO data provides important insights for both researchers and patients. While PROs are often included as an endpoint in blood cancer clinical trials, they are frequently not reported in the final publications. Further, when PRO data is reported, it typically shows improvement or no change, indicating bias in the way the data is presented. When PRO data is not shared, essential details about the patient experience are lost. Including PRO data in studies and publications is vital for helping providers and patients make more informed decisions about care.

HealthTree is committed to elevating patient perspectives. To achieve this, we publish our research at medical conferences and online to ensure that information about patient experiences is widely available to researchers, medical providers, patients, and caregivers.

To participate in research with HealthTree by taking simple surveys to collect patient-reported outcomes, like in the above article, follow the link below.

HealthTree Research

Source:

Patient-Reported Outcomes in Phase 3 Clinical Trials for Blood Cancers: A Systematic Review

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Substance Use Is Often Overlooked in Cancer Care

Why Cancer and Substance Use Often Overlap

To read more about opioid use and pain in cancer, visit this article of HealthTree Research findings by clicking the button below.

Managing Pain and Opioid Use for Myeloma Patients

Tobacco and alcohol are the most widely used substances that raise cancer risk.

\n
Tobacco causes about 30% of all cancer deaths, including 80% of lung cancer deaths. It is also linked to cancers of the mouth, throat, larynx, esophagus, stomach, colon, rectum, pancreas, liver, kidney, bladder, cervix, and even blood cancers. Tobacco not only increases the risk of cancer, but can also produce metabolic and circulation issues in the body that make receiving cancer treatment more challenging.
\n
\n
Alcohol is responsible for about 3.5% of cancer deaths. The risk is proportional to the intake; higher amounts over long periods pose a higher risk. For women, heavy use means more than 4 drinks per day or 8 per week. For men, it’s more than 5 drinks per day or 15 per week. Alcohol is processed by the liver and can interfere with the metabolism of other cancer treatments, increase the risk of worse side effects, and, in some cases, inactivate the medication.
\n

These facts are important because quitting tobacco and reducing alcohol use, even after a cancer diagnosis, can still lower future cancer risks and improve health.

Other Substances That Can Complicate Cancer Treatment and Health

Aside from tobacco and alcohol, the following substances are also frequently seen among patients and can interfere with treatment:

\n
Cannabis or marijuana is a natural opioid that can be synthesized into CBD. It can be prescribed by a doctor and administered under controlled conditions. Medical-grade marijuana has strict sanitary regulations and can be beneficial for many people. There is a risk of fungal infection of the lungs associated with marijuana produced in unofficial or unsanitary settings. You can read more about safe uses of cannabis and its risks from the American Thoracic Society here.
\n

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Anabolic steroids are the most commonly used drugs among athletes to improve physical performance and aesthetic appearance. These drugs interact with hormone cycles and can also have a negative impact on other organs such as the liver, the cardiovascular, central nervous, musculoskeletal, endocrine, and reproductive systems. It is important to note that anabolic steroids are different from the commonly used steroids in cancer treatments.
\n
\n
Injection drugs, including heroin. These drugs are administered directly into the veins, and their use has risks besides addiction. They can cause vascular strokes, blood and tissue infections, and blood-transmitted diseases like hepatitis and HIV.
Prolonged use can affect the main veins, limiting the option for intravenous cancer medications or increasing the need for longer hospital stays to monitor its applications.
\n
Synthetic drugs, such as methamphetamine (“meth” or “crystal”) is associated with liver cancer and affects psychiatric and physical performance. It is a toxic chemical substance for multiple organs, including the heart, brain and other liver.
\n
Cocaine is a powder absorbed by the mucous membranes. While cocaine’s impact on cellular processes is not fully understood, researchers speculated that the drug might stimulate white blood cell activity and growth. This could potentially speed up the formation of genetic errors that could lead to cancer. Read more about the link of cocaine and cancer here.
\n

Challenges in Coordinating Cancer and SUD Treatment

Patients taking naltrexone for alcohol use disorder may not be able to use certain cancer pain treatments that act on the same parts of the brain.

How Does Stigma Affect People With Substance Use Disorders?

Reducing Stigma and Improving Support

When harm reduction strategies are used with all patients, stigma can be reduced, and more people feel safe sharing their needs.

The way we name things impacts stigma around substance use disorders

\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n

\n Preferred terms that do not stigmatize \n	\n Common terms that might stigmatize \n	\n Why change the language we use? \n
\n Person or patient *with* a: \n \n \n Substance use disorder \n \n \n Opioid use disorder \n \n \n Alcohol use disorder \n \n \n	\n Someone who is a/an: \n \n \n Junkie \n \n \n Addict \n \n \n Alcoholic \n \n \n	\n \n \n Person-first language \n \n \n Demonstrates a person “has” a problem, rather than “is” the problem \n \n \n Avoids negative associations or personal blame \n \n \n
\n \n \n Use (illicit substance) \n \n \n Misuse (prescription medications) \n \n \n	\n \n \n Substance abuse \n \n \n	\n \n \n “Abuse” is associated with negative judgments and punishment \n \n \n
\n \n \n Substance-free \n \n \n Expected/unexpected findings \n \n \n	\n \n \n Clean or dirty \n \n \n Positive/negative \n \n \n	\n \n \n Preferred terms are clinically accurate, non-stigmatizing \n \n \n
\n \n \n Recovery \n \n \n Remission \n \n \n Substance-free \n \n \n	\n \n \n Clean \n \n \n Sober \n \n \n	\n \n \n Preferred terms are clinically accurate and non-stigmatizing, similar to other medical conditions \n \n \n
\n \n \n Addiction \n \n \n	\n \n \n Habit \n \n \n Behavior \n \n \n	\n \n \n Substance use disorders are medical conditions \n \n \n “Habit” or “behavior” is inaccurate and implies control \n \n \n

Chart from Addiction in Patients With Cancer: Challenges and Opportunities

Sourced from National Institute on Drug Abuse (2020)

Moving Toward More Inclusive, Effective Cancer Care

For more information and help for people with substance use disorders, you can visit the following assistance resources:

SAMHSA - Substance Abuse and Mental Health Services https://www.samhsa.gov/

Medication Assistance Therapy Care Clinic https://www.matcareclinics.com/

American Addiction Centers https://drugabuse.com/addiction/health-issues/cancer/

CDC Mental Health Resources https://www.cdc.gov/mental-health/caring/index.html#:~:text=Key%20points,to%20the%20nearest%20crisis%20center.

American Society of Addiction Medicine https://www.asam.org/

Start Your Recovery Organization https://startyourrecovery.org/experiences/co-occurring-disorders

Sources:

How Blood Cancer Treatments and Other Risk Factors May Impact Brain Function

Several factors can contribute to changes in brain function as a result of blood cancer treatment.

The treatments themselves, like chemotherapy, targeted therapy, radiation, and immunotherapy, can affect brain health by:

Crossing the barrier that protects your brain and directly impacting brain cells.
Triggering inflammation through immune system activation, which clouds brain function.
Remaining oxidative stress after treatment—caused by too many free radicals and not enough antioxidants—can damage healthy cells and trigger inflammation, affecting areas like the brain.

Factors That Increase Your Risk

Even without treatment, cancer cells can increase inflammation in the body, which may dampen brain function.

What Do Symptoms Look Like?

The brain-related symptoms you may experience from certain blood cancer treatments may include:

Mild to moderate symptoms: trouble thinking clearly, confusion, fatigue, headaches
More serious issues (rare): difficulty speaking, tremors, seizures

Tips for Recovery

If your brain-related symptoms aren’t improving over time, it’s important to get help. Here are some supportive strategies:

Consult with your blood cancer specialist: Talk to your doctor about ways to manage treatment side effects. For example, if you're experiencing headaches from a cancer therapy, ask what can help. They might recommend adding a headache-relief medication, adjusting the dose, or switching to a different treatment.
Nutrition support: Work with a registered dietitian to reduce inflammation and address nutrient gaps that directly impact brain health.
Visit a functional neurologist: See a functional neurologist who can pinpoint which areas of your brain need support and create a personalized therapy plan using targeted eye, hand, or balance exercises to help strengthen them. They may also suggest adding certain medications. This differs from a neurologist, who focuses mostly on medication to treat symptoms.
Mental health support: A licensed therapist can help you manage stress, anxiety, or trauma, and teach coping skills—like mindfulness and breathing techniques—that may reduce inflammation and improve your quality of life.
Lifestyle habits: Getting enough sleep, staying hydrated, exercising moderately, and eating nutrient-dense foods can support brain health.

Key Takeaways

Brain-related side effects from blood cancer treatments can occur and range from mild brain fog to more serious neurological issues.

Even if side effects are expected, working closely with your care team is key to finding the right solutions for your cognitive health and overall well-being.

Discover Patient-Reported Side Effect Solutions

Access Side Effect Solutions

!AD!

Sources:

The Committee's main responsibility is to distribute federal funds that ensure that agencies like the FDA and the NIH have the necessary resources to drive scientific discoveries.

During the hearing, several experts and advocates testified, sharing their views on the benefits of federal funding and the urgent need for continued investment in life-saving research.

Federal Funds Advance Discovery, Save Lives, and Offer Hope

Maintaining strong federal support allows researchers to keep making progress, develop new treatments faster, and expand access to clinical trials for patients across the country.

Investing in Innovation and Public Health

How You Can Help Advance Research Through Your Experience

Click the buttons below to access these simple surveys and to learn the results of past patient-accelerated research.

Make an Impact with Brief Blood Cancer Surveys

News Updates on Real-World Research

Sources:

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What Is Thrombocytopenia?

A New Medication To Improve Platelet Levels

Eltrombopag treats low platelet counts (thrombocytopenia) in CMML patients, as well as in adults and children with chronic immune thrombocytopenic purpura and severe aplastic anemia.

What Are the Side Effects of Eltrombopag?

Some side effects that may occur with this use of this treatment include:

Swelling of the face, hand, lower legs or feet
Fatigue
Chills
Cough
Fever
Nausea
Loss of appetite
Rash

A New Clinical Trial

This trial lasted for 12 weeks:

Patients received eltrombopag at a starting dose of 100 mg once daily, which was later changed to 50 mg/day.
The Dose was adjustable up to 300 mg/day.
Patients responding well could continue the treatment for up to 24 months.
This group had an overall survival rate of 47% and a two-year progression-free survival rate of 23%.

Conclusion

Become your best self advocate with HealthTree, we provide free resources to help you stay on top of your health!

Keep Learning More

Source:

Eltrombopag in chronic myelomonocytic leukemia with severe thrombocytopenia. A Groupe Francophone des Myélodysplasies (GFM) study

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What corticosteroids are and how they work in the body

Corticosteroids work through both \"genomic\" and \"non-genomic\" pathways:

Genomic effects: Once inside a cell, corticosteroids bind to receptors and move into the nucleus to change how certain genes are expressed. This mainly decreases the production of inflammatory molecules.
Non-genomic effects: Corticosteroids can also act quickly at the cell membrane, blocking early stages of inflammation within minutes.

Understanding this is important because it explains why corticosteroids can act both rapidly and over time to control treatment-related symptoms.

Corticosteroids to support blood cancer treatments

Corticosteroids are used before or alongside cancer therapies. The benefits they provide include:

Reducing allergic-like reactions
Managing inflammation
Decreasing nausea and vomiting
Improving a poor appetite

This supportive use helps patients tolerate their blood cancer treatment better and maintain a higher quality of life.

Side effects and what patients should know

While corticosteroids are helpful, they also come with potential risks. Common side effects include:

Increased risk of infections
High blood sugar levels
Mood changes (such as anxiety or irritability)
Weight gain
Bone loss over time

Summary

We need your help! Easily contribute to blood cancer research

Make an Impact with Brief Blood Cancer Surveys

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Sources:

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A recent clinical study evaluated vibecotamab in patients with myeloid disorders who had limited treatment options. The study included patients with:

\n
Myelodysplastic syndrome (MDS) or chronic myelomonocytic leukemia (CMML) who have not responded to previous hypomethylating agents (azacitidine, decitabine).
\n
\n
Acute myeloid leukemia (AML) and in remission but with minimal residual disease (MRD) positive, meaning small amounts of leukemia cells remained in the body despite initial treatment.
\n

Key Study Findings

Myelodysplastic Syndrome and Chronic Myelomonocytic Leukemia

68% of patients showed improvement
63% achieved complete remission, meaning cancerous cells were no longer detectable in the bone marrow
It is particularly telling that all 3 patients with CMML achieved a complete remission
The median duration of response was 5.2 months
Patients in the study lived for about 10 months on average after starting the treatment

Acute Myeloid Leukemia

28% of patients achieved MRD negativity, meaning there were no detectable leukemia cells in the bone marrow.
All responses happened within the first treatment cycle.
Some patients maintained their remission for over two years, while others relapsed after stopping treatment.
There was no connection between how likely someone was to respond and the amount of CD123 expressed in cancer cells.

What’s the Safety Profile of Vibecotamab?

Vibecotamab was considered by the researchers to be generally well tolerated
The most common side effect was infusion-related reactions, which were mostly mild to moderate
No patients had to stop treatment due to severe side effects
Unlike some other treatments, vibecotamab caused minimal suppression of healthy blood cell production

What This Means for Patients

If you want to read more about treatment advances and clinical trial updates, bookmark the HealthTree News page to browse our articles, written just for you!

Keep Reading More Articles

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What Is Venetoclax?

Combining Venetoclax with HMAs

The overall survival (OS) of patients was 25.1 months.
Overall response rate (ORR) for HMAs alone was 46% and 95% for those treated with venetoclax + HMAs combination.
A total of 29 patients went on to receive allogeneic stem cell transplant (alloSCT).
There was no significant overall survival difference between the HMA+ venetoclax combination versus HMAs alone (19.1 months versus 19.1 months).

Conclusion

If you or a loved one is navigating CMML and want to stay informed about the latest treatments, studies, and research updates, be sure to follow our news site for ongoing coverage and insights.

VISIT HEALTHTREE CMML NEWS

Source:

Venetoclax (VEN) Improves Response Rates but Not Survival in Patients with Chronic Myelomonocytic Leukemia (CMML) Treated with Hypomethylating Agents (HMA): A Multicenter, Propensity Score Analysis

Messages Others May Be Telling You

In her new book, The Big C ² - stories from the chronic side of cancer, Ruth Fein writes about Michele, who lives with chronic leukemia.

\n
Recently, two of her closest friends made comments that had Michele trying desperately to keep her raised eyebrows from freezing in place. “You are lucky you have never really felt bad,” is the paraphrase she remembers. “What?!?”
\n

\n
“Well, we always thought you looked great, so you must feel great,” they said when she finally had a heart-to-heart with them about how shocked she was by their comments.
\n

\n
“These were days that I couldn’t even fathom picking up the phone; I didn’t even want to get dressed or wash my hair... or get out of bed,” she recalls thinking. Then she was hit by the common denominator. She never explained, even to her besties, how badly she was feeling.
\n

Messages You May Be Telling Yourself

One of the most helpful things you can do is find ways to focus on the parts of yourself that bring you joy and purpose while acknowledging the reality of your health and any related limitations.

For example, if you’re naturally social but feel isolated due to infection risks, talk to your doctor about preventative strategies that could help you safely reconnect with others.

Setting You Up for Success

Below, we’ve included examples of responses you can say if someone says, “But you don’t look sick.”

Responding to “You Don’t Look Sick”

1. Acknowledge the good intent, but clarify the impact:

“I appreciate that, and I know you mean well, but comments like that can actually make me feel like a “cancer imposter” – like I’m not really going through this.”
“Thanks, I know it might seem like I’m okay on the outside, but it doesn’t reflect how I feel inside.”

2. Use “I” statements to express how it feels:

“I know I don’t look sick, and that’s actually one of the hardest parts—because I’m really struggling internally.”
“I’ve learned that appearances can be deceiving, even to myself sometimes.”

3. Gently educate if the moment feels right:

“It’s an invisible illness—things like fatigue, brain fog, and pain don’t always show up physically.”

4. Share more if they seem open; if not, protect your energy:

“If you’re curious, I’d be happy to share what it’s really like to live with this.”
Or simply: “Thanks,” and move on if that’s more comfortable at the time.

5. Validate your own experience:

You don’t have to justify how you look to others or yourself. While it poses emotional challenges not to look sick, it can also help you feel better about yourself, even while you don’t feel well on the inside.
When it comes to lengthy explanations, save your energy for people who truly matter—those who want to understand.

Bottom line: Use direct communication, not defensiveness. Assume good intent, but honor your truth. You can advocate for understanding without having to prove your pain.

Summary

Connect with a Chronic Blood Cancer Specialist

To find a specialist, click the directory link below that matches your type of chronic blood cancer:

Chronic eosinophilic leukemia (CEL)
Chronic lymphocytic leukemia (CLL)/Small lymphocytic lymphoma (SLL)
Chronic myeloid leukemia (CML)
Chronic myelomonocytic leukemia (CMML)
Chronic neutrophilic leukemia (CNL)
Essential thrombocythemia
Follicular lymphoma
Multiple myeloma
Myelodysplastic syndromes (MDS)
Myelofibrosis
Polycythemia vera
Waldenstrom's macroglobulinemia

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Sources:

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A Path Through Adversity: Signs of Post-Traumatic Growth

One of the most uplifting findings of the survey was that many patients are experiencing growth as a result of their cancer experience.

Changed Priorities: 75% of respondents said their values shifted moderately or more as a result of their diagnosis
Appreciation for the Value of Life: 80% gained a moderate or deeper appreciation for life’s value
Increased Resilience: 68% now feel moderately or more confident handling difficulties
Personal Strength and Connection: Many discovered they were stronger than they thought and gained a greater sense of closeness with others

\n
“I learned a great deal about how wonderful people are,” one respondent reflected—an insight shared by 84% of participants.
\n

What Flourishing Looks Like Today

The survey invited participants to rate how they feel today in several aspects of daily living.

Life Satisfaction and Happiness

Despite the physical and emotional challenges of living with blood cancer, patients have:

7.10 out of 10 average life satisfaction
7.1 out of 10 happiness rating

Many respondents reported feeling generally satisfied with life, with 50% scoring themselves 8 or higher.

Mental and Physical Health

Meaning and Purpose

The survey also found high levels of personal meaning and purpose:

86% of people feel the things they do in life are worthwhile
7.2 out of 10 average understanding of their life's purpose

Faith and Spirituality: Meaning Beyond Medicine

The survey revealed a wide range of spiritual and religious experiences and beliefs.

85% believe in God or a higher power
37% believe God is active in their lives
26% believe in a higher power or divine being
66% attend religious services
64% engage in personal spiritual practices monthly or more

!AD!

Why This Research Matters

This survey serves as a powerful reminder that a cancer diagnosis touches every aspect of a person’s life, not just the physical.

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“We need to understand not just how patients survive—but how they thrive.” shared HealthTree's research team.
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Add Your Voice

Participate in the Flourishing Survey

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Main points:

ROR1 is a receptor found on the surface of cancer cells, rarely present in healthy adult cells, making it a promising treatment target for various blood cancers.
Early studies show that therapies targeting ROR1—such as CAR T-cell therapy, monoclonal antibodies, and small molecule inhibitors—may be effective in certain blood cancers like CLL and MCL.
Combining ROR1-targeted therapies with other treatments like venetoclax may help overcome drug resistance and improve patient outcomes.

What Is ROR1 and Why Does It Matter for Blood Cancer Patients?

Clinical Trial Treatment Options That Target ROR1

Several types of therapies are being developed to block ROR1 and stop its cancer-supporting activity:

Monoclonal antibodies like cirmtuzumab designed to attach to ROR1 on cancer cells and block its signals. Early trials show this approach may be effective when combined with other treatments like venetoclax, which targets another cancer-promoting protein, BCL-2.
Small molecule inhibitors such as KAN0441571C are designed to enter cancer cells and shut down ROR1 from the inside. These are showing potential, especially in patients whose cancers resist standard therapies.
Antibody-drug conjugates (ADCs) like zilovertamab vedotin deliver chemotherapy directly to ROR1-positive cells, limiting damage to healthy cells. Click here to access a recruiting clinical trial for relapsed/refractory CLL, MCL, and follicular lymphoma patients.
CAR T-cell therapy that modifies a patient’s own immune cells to target ROR1-positive cancer cells. This approach is still in early testing.
Bispecific antibodies engineered to bring T-cells into close contact with cancer cells that express ROR1, helping the immune system do its job more effectively.

Why Combination Therapies Could Be the Future

For example, combining anti-ROR1 therapies with venetoclax may work better than either alone. This is especially important for people with high-risk or relapsed disease.

Bottom Line

Continue Exploring Advancements in Blood Cancer Treatments

!AD!

Source:

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Therapeutic advances in the targeting of ROR1 in hematological cancers
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Understanding Medicare and Medicaid Changes

The Current Situation

What These Cuts Mean

State-by-State Impact

Additional Policy Changes

Impact on Social Security and Healthcare Access

Social Security Processing Delays

Tips for Disability Applications

Rural Healthcare Concerns

Treatment Access and Clinical Trial Updates

Supply Chain Concerns

Impact on Clinical Trials

Research and Trial Availability

Taking Action

A lot is going on right now, and we may be processing this for quite a while. This is definitely not a time to ignore what is going on, as one or more of these issues may affect you directly.

Stay Connected and Informed

Join the Financial Support Group

Sources:

HealthTree Webinar: Navigating Financial Uncertainty: Proactive Tips for Blood Cancer Patients and Families. March 4, 2025
American Hospital Association. Feb 2025 Fact Sheet: Telehealth Waivers and ACA
KFF: The Math is Conclusive: Major Medicaid Cuts are the Only Way to Meet House Budget Resolution Requirements. Alice Burns, March 7, 2025
KFF: Workforce Reduction at Social Security Could Affect Medicare and Medicaid Coverage. Juliette Cubanski, March 3, 2025

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Under her leadership, our foundation has revolutionized patient support and cancer research through three key pillars:

Comprehensive education through podcasts, webinars, and our dedicated university platform
Community support connecting patients and caregivers
An innovative data registry accelerating critical research in blood cancer

We congratulate our CEO on this recognition and her leadership of the HealthTree Foundation's mission to accelerate cancer research and improve patient outcomes.

Join HealthTree Community

Join Your Regional Cure Team

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What Is Thrombocytopenia?

A New Medication To Improve Platelet Levels

Eltrombopag treats low platelet counts (thrombocytopenia) in CMML patients, as well as in adults and children with chronic immune thrombocytopenic purpura and severe aplastic anemia.

What Are the Side Effects of Eltrombopag?

Some side effects that may occur with this use of this treatment include:

Swelling of the face, hand, lower legs or feet
Fatigue
Chills
Cough
Fever
Nausea
Loss of appetite
Rash

A New Clinical Trial

This trial lasted for 12 weeks:

Patients received eltrombopag at a starting dose of 100 mg once daily, which was later changed to 50 mg/day.
The Dose was adjustable up to 300 mg/day.
Patients responding well could continue the treatment for up to 24 months.
This group had an overall survival rate of 47% and a two-year progression-free survival rate of 23%.

Conclusion

Become your best self advocate with HealthTree, we provide free resources to help you stay on top of your health!

Keep Learning More

Source:

Eltrombopag in chronic myelomonocytic leukemia with severe thrombocytopenia. A Groupe Francophone des Myélodysplasies (GFM) study

How Do HMAs Work?

HMAs are considered the standard treatment for CMML. They can improve blood cell counts and decrease the need for transfusions.

By reversing the DNA methylation, they can reprogram tumor cells.
They can activate genes that help healthy cells mature.
They can kill cells that are dividing abnormally quickly.
HMAs are believed to re-express tumor suppressors.
Patients who progress to acute myeloid leukemia (AML) after responding to HMAs have a median overall survival of 8 months.

How Are HMAs Used?

Azacitidine (Vidaza): has effects on both DNA and RNA.
Decitabine (Dacogen): acts only at the DNA level.
Decitabine and Cedazuridine (Inqovi).

Other Treatments For CMML

Hydroxyurea: A chemotherapy drug that can help some CMML patients live longer.
Pembrolizumab: A humanized monoclonal antibody that may be effective in patients who failed HMA treatment.
A combination of HMAs and Venetoclax has shown good results in CMML, with an overall response rate of 62%.
In 2023, the FDA granted fast-track designation to IO-202 for treating patients with relapsed/refractory CMML. This anti-LILRB4 monoclonal antibody is being investigated as an immunotherapy for blood cancers. As of 2024, at the American Hematology Association, updates from a phase 1 trial showed promising results.

Conclusion

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Source:

Are Hypomethylating Agents the Best First-Line Choice for Treating CMML?

What Is TET2?

Mutated TET2 Impact

How Are CMML And TET2 Connected?

Conclusion

You can keep learning with HealthTree's comprehensive updates on research news, conferences and more. Click the button below to browse our different article categories.

Read More CMML News

Source:

Gene-mutation pathway discovery paves way for targeted blood cancers therapies

A recent clinical study evaluated vibecotamab in patients with myeloid disorders who had limited treatment options. The study included patients with:

\n
Myelodysplastic syndrome (MDS) or chronic myelomonocytic leukemia (CMML) who have not responded to previous hypomethylating agents (azacitidine, decitabine).
\n
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Acute myeloid leukemia (AML) and in remission but with minimal residual disease (MRD) positive, meaning small amounts of leukemia cells remained in the body despite initial treatment.
\n

Key Study Findings

Myelodysplastic Syndrome and Chronic Myelomonocytic Leukemia

68% of patients showed improvement
63% achieved complete remission, meaning cancerous cells were no longer detectable in the bone marrow
It is particularly telling that all 3 patients with CMML achieved a complete remission
The median duration of response was 5.2 months
Patients in the study lived for about 10 months on average after starting the treatment

Acute Myeloid Leukemia

28% of patients achieved MRD negativity, meaning there were no detectable leukemia cells in the bone marrow.
All responses happened within the first treatment cycle.
Some patients maintained their remission for over two years, while others relapsed after stopping treatment.
There was no connection between how likely someone was to respond and the amount of CD123 expressed in cancer cells.

What’s the Safety Profile of Vibecotamab?

Vibecotamab was considered by the researchers to be generally well tolerated
The most common side effect was infusion-related reactions, which were mostly mild to moderate
No patients had to stop treatment due to severe side effects
Unlike some other treatments, vibecotamab caused minimal suppression of healthy blood cell production

What This Means for Patients

If you want to read more about treatment advances and clinical trial updates, bookmark the HealthTree News page to browse our articles, written just for you!

Keep Reading More Articles

Messages Others May Be Telling You

In her new book, The Big C ² - stories from the chronic side of cancer, Ruth Fein writes about Michele, who lives with chronic leukemia.

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Recently, two of her closest friends made comments that had Michele trying desperately to keep her raised eyebrows from freezing in place. “You are lucky you have never really felt bad,” is the paraphrase she remembers. “What?!?”
\n

\n
“Well, we always thought you looked great, so you must feel great,” they said when she finally had a heart-to-heart with them about how shocked she was by their comments.
\n

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“These were days that I couldn’t even fathom picking up the phone; I didn’t even want to get dressed or wash my hair... or get out of bed,” she recalls thinking. Then she was hit by the common denominator. She never explained, even to her besties, how badly she was feeling.
\n

Messages You May Be Telling Yourself

One of the most helpful things you can do is find ways to focus on the parts of yourself that bring you joy and purpose while acknowledging the reality of your health and any related limitations.

For example, if you’re naturally social but feel isolated due to infection risks, talk to your doctor about preventative strategies that could help you safely reconnect with others.

Setting You Up for Success

Below, we’ve included examples of responses you can say if someone says, “But you don’t look sick.”

Responding to “You Don’t Look Sick”

1. Acknowledge the good intent, but clarify the impact:

“I appreciate that, and I know you mean well, but comments like that can actually make me feel like a “cancer imposter” – like I’m not really going through this.”
“Thanks, I know it might seem like I’m okay on the outside, but it doesn’t reflect how I feel inside.”

2. Use “I” statements to express how it feels:

“I know I don’t look sick, and that’s actually one of the hardest parts—because I’m really struggling internally.”
“I’ve learned that appearances can be deceiving, even to myself sometimes.”

3. Gently educate if the moment feels right:

“It’s an invisible illness—things like fatigue, brain fog, and pain don’t always show up physically.”

4. Share more if they seem open; if not, protect your energy:

“If you’re curious, I’d be happy to share what it’s really like to live with this.”
Or simply: “Thanks,” and move on if that’s more comfortable at the time.

5. Validate your own experience:

You don’t have to justify how you look to others or yourself. While it poses emotional challenges not to look sick, it can also help you feel better about yourself, even while you don’t feel well on the inside.
When it comes to lengthy explanations, save your energy for people who truly matter—those who want to understand.

Bottom line: Use direct communication, not defensiveness. Assume good intent, but honor your truth. You can advocate for understanding without having to prove your pain.

Summary

Connect with a Chronic Blood Cancer Specialist

To find a specialist, click the directory link below that matches your type of chronic blood cancer:

Chronic eosinophilic leukemia (CEL)
Chronic lymphocytic leukemia (CLL)/Small lymphocytic lymphoma (SLL)
Chronic myeloid leukemia (CML)
Chronic myelomonocytic leukemia (CMML)
Chronic neutrophilic leukemia (CNL)
Essential thrombocythemia
Follicular lymphoma
Multiple myeloma
Myelodysplastic syndromes (MDS)
Myelofibrosis
Polycythemia vera
Waldenstrom's macroglobulinemia

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