Hi, I'm Urvi Shah, a hematologist, oncologist, and physician scientist at Memorial Sloan Kettering Cancer Center. I'm excited to talk to you about our recent newly diagnosed study looking at a dietary intervention. We just published the pilot neutrovention data in cancer discovery this year, and we have shown detailed analysis how a low risk dietary intervention can improve microbiome, metabolism, and immune health for patients with precursor disorders. We now want to study this in newly diagnosed myeloma to understand how a low risk intervention, like a dietary change, could impact a quality of life and treatment response. We do know that features like weight gain, diabetes or pre-diabetes, microbiome dysbiosis, or abnormalities can all lead to worse outcomes during treatment. So we would like to see with a dietary intervention if we could help patients tolerate chemotherapy better and possibly respond. In this study, there will be 220 patients and more spread across the United States. As long as you're getting your myeloma treatment at an academic myeloma center and you're getting four cycles of daratumum, amyloidomide, bortezomib, and dexamethasone, a 28-day cycle regimen, as long as your site also uses the Epic electronic medical record, please reach out to us if you're interested. First the study is being done during the initial treatment and after we need the patients who are interested to reach out to us before cycle one, day 15, so within two weeks of starting treatment of the daratumum amyloidomide, DRVD as we call it. This study will have two groups of participants will get randomized into one or the other group. Both groups get quite a bit of information and different benefits. The group that gets the dietary intervention during the chemotherapy will get meals shipped to them, lunch and dinner, for 12 weeks starting from cycle two, day one until end of induction. And we also will get group coaching and personalized nutrition coaching every two weeks. The other group will get the intervention or information after the induction chemotherapy, We want to see whether it makes a difference to give it during chemotherapy or after. That group will receive a $200 gift card at the end of the intervention, also a meeting with our dietitian and a lot of information about the dietary changes after their chemotherapy. So both groups get some information about diet, just one during treatment and one after. If you are interested or you know somebody diagnosed with myeloma and interested, please feel free to reach out. If you're not sure you're eligible, we can go through that and check and see if you are eligible or reach out to get that information. Please email us the sooner the better if you are thinking about this because it needs to be very soon after starting treatment that you sign up for the study. You can email us at shaanutrivention at mskcc.org and one of our team members will reach back out to you and discuss the study and help set it up.
HealthTree • December 12, 2025