Delayed Neurotoxicity After BCMA CAR-T: Warning Signs for Caregivers

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Some neurological side effects of CAR-T therapy can appear weeks or even months after treatment, often when patients are back home with their local oncologist. In this HealthTree video, we explain delayed neurotoxicity seen with certain BCMA-directed CAR-T therapies for multiple myeloma and how it differs from ICANS. You'll learn about cranial nerve palsy (facial droop, slurred speech), the Parkinson-like movement and neurocognitive syndrome, which changes need emergency care, and who to contact after care returns to a community oncologist.

Part of HealthTree University's Caring with Confidence: A Practical Guide for CAR-T Caregivers course.

Timestamps:

0:00 Introduction

0:28 Delayed neurotoxicity vs. ICANS

1:20 Cranial nerve palsy: facial droop and slurred speech

2:25 Movement and neurocognitive toxicity (Parkinson-like)

3:21 Subtle changes: flat affect, memory, and behavior

4:20 Changes that need emergency care

5:39 Who to contact back in the community

6:58 Falls and final thoughts

This video is for educational purposes only and is not medical advice. Always follow your CAR-T care team's instructions.

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