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Thumbnail for How Is Myeloma Treatment Changing? Quadruplets, CAR-T, Bispecifics and New Therapies | IMS 2026
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How Is Myeloma Treatment Changing? Quadruplets, CAR-T, Bispecifics and New Therapies | IMS 2026

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Thumbnail for Personalized Vaccine for Smoldering Myeloma: Could It Prevent Progression? | IMS 2026
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Personalized Vaccine for Smoldering Myeloma: Could It Prevent Progression? | IMS 2026

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JoshHolt
Multiple Myeloma Discussion • 5d ago
Pain management
I'm all about the natural side of thinks, into naturopathy and am trying to avoid any opioids but it's getting to interfere with my quality of life, wondering what everyone does for pain management?
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nancynomad
Multiple Myeloma Discussion • 5d ago
Hyperlipidemic myeloma and MAGa
I believe I may have hyperlipidemic myeloma, a rare variant of myeloma which leads to high levels of cholesterol (usually MM is associated with low or normal cholesterol levels), possibly by decreased lipid degradation due to paraproteins complexing with lipoproteins, impaired lipolytic activity and paraprotein binding the LDL receptor inhibiting clearance. See “Elevated LDL Secondary to MM” https://www.lipid.org/resource/elevated-ldl-secondary-to-multiple-myeloma/. If it is due to paraproteins binding with lipoproteins, it would be a form of MAGa – monoclonal autoimmune gammopathies. While the origin of the antibody is a neoplastic clone of cells rather than a standard systemic autoimmune defect, the end result—a self-protein being targeted and disrupted by an antibody—is functionally an autoimmune phenomenon. From “MAGa: Monoclonal Autoimmune Gammopathies” published May 27, 2026 https://www.mdpi.com/2072-6694/18/11/1770: “monoclonal immunoglobulins (as measured in the M-spike), have long been overlooked in clinical research because they are thought to have no significant antibody function…In monoclonal autoimmune gammopathies (MAGa), repeated exposure to autoantigens may contribute to the development of multiple myeloma. Alternatively, these associations could reflect an underlying immune disorder that exists years before the diagnosis of multiple myeloma, thereby illustrating the natural course of the disease.” There are tests which can confirm both diagnoses, which I hope to have soon. But I wanted to ask, does anyone have any experience with hyperlipidemic myeloma or with MAGa?
Thumbnail for Talquetamab Taste Changes in Multiple Myeloma: What Helps and What Doesn’t? -TALISMAN Study | #IMS26
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Talquetamab Taste Changes in Multiple Myeloma: What Helps and What Doesn’t? -TALISMAN Study | #IMS26

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Thumbnail for Transplant-Ineligible Myeloma: Can Daratumumab  + Bortezomib Maintenance Improve Outcomes? | #IMS26
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Transplant-Ineligible Myeloma: Can Daratumumab + Bortezomib Maintenance Improve Outcomes? | #IMS26

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RickyT
Multiple Myeloma Discussion • 6d ago
Hip pain
I was diagnosed with Smoldering Multiple Myreloma 9/2024. My labs have been stable for the last 2yrs without any consistent climb in numbers. This past Friday, I began to notice right hip pain, most when first standing but it subsided later in the day. Saturday & today, the pain has been more noticeable & more frequent; again when first standing or after standing for a while. Has anyone experienced such a case or anything like this?
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Mandjcast
Multiple Myeloma Discussion • 6d ago
Plasma Cell Leukemia Patients
Hi. I am a 21 year survivor. Would love to chat with others who have this disease.
Thumbnail for Does Intensive Treatment Affect Quality of Life in High-Risk Myeloma? | RADAR Trial | IMS 2026
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Does Intensive Treatment Affect Quality of Life in High-Risk Myeloma? | RADAR Trial | IMS 2026

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Thumbnail for What a 3-Month PET-CT Can Predict About CAR-T Outcomes in Multiple Myeloma | IMS 2026
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What a 3-Month PET-CT Can Predict About CAR-T Outcomes in Multiple Myeloma | IMS 2026

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Thumbnail for Can Multiple Myeloma Be Cured? MRD Negativity, Stopping Treatment & Confirming Cure | IMS 2026
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Can Multiple Myeloma Be Cured? MRD Negativity, Stopping Treatment & Confirming Cure | IMS 2026

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Thumbnail for AL Amyloidosis Bispecific Trial: Who Qualifies, Response , Side Effects & Organ Response | IMS 2026
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AL Amyloidosis Bispecific Trial: Who Qualifies, Response , Side Effects & Organ Response | IMS 2026

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Thumbnail for In Vivo CAR-T for Multiple Myeloma: Could It Improve Access and Skip Chemotherapy? | IMS 2026
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In Vivo CAR-T for Multiple Myeloma: Could It Improve Access and Skip Chemotherapy? | IMS 2026

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Thumbnail for Etentamig for Relapsed Multiple Myeloma: New Bispecific Shows Strong Results, Low CRS | IMS 2026
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Etentamig for Relapsed Multiple Myeloma: New Bispecific Shows Strong Results, Low CRS | IMS 2026

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Thumbnail for Multiple Myeloma Treatment for Older Adults: Who Should Get Quadruplet Therapy? | IMS 2026
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Multiple Myeloma Treatment for Older Adults: Who Should Get Quadruplet Therapy? | IMS 2026

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