Dr. Stein is interested in the clinical investigation and clinical epidemiology of the classical Myeloproliferative Neoplasms. He has focused on the correlation between molecular and genetic abnormalities and clinical phenotype in these disorders, as well as the influence of gender on disease manifestations. He currently serves as the institutional PI for an international consortium (MPD-RC) as well as the institutional PI for JAK-inhibitor studies in patients with Myelofibrosis and Polycythemia Vera. Dr. Stein is collaborating with Dr. Crispino's lab, evaluating new druggable targets in the MPN, along with Dr. Platanias, who is studying interferon signaling in the MPN. Finally, Dr. Stein is working with Dr. Kwaan to focus on the role of tissue-factor and PAI-1-bearing microparticles and their role in thrombosis in patients with MPN.