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Thumbnail for Can you start treatment on one JAK2 inhibitor and later switch to a different JAK2 inhibitor? Why would this be done?
Playlist: JAK2 Inhibitors

Can you start treatment on one JAK2 inhibitor and later switch to a different JAK2 inhibitor? Why would this be done?

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Thumbnail for What are the latest advancements and future directions in the development of JAK2 inhibitors for myelofibrosis?
Playlist: JAK2 Inhibitors

What are the latest advancements and future directions in the development of JAK2 inhibitors for myelofibrosis?

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caraofeve
General Discussion • September 25, 2025
Considering Not Getting an ASCT - Your Experiences?
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Hello everyone and thank you in advance for reading and any input you can provide? Has anyone had any experience or information related to after induction therapy opting not to proceed with a ASCT although eligible and it was recommended (not frail)? I understand the standard of care and process entailed therein however have not heard much detailed information or testimony as to why anyone opted not to proceed with ASCT (what factors were that decision was based on) and what was their outcome was? I am trying to balance both side of the coin. I am scheduled for my ASCT consult on October 15th at the Mayo Clinic. Any advice or information is greatly appreciated. I want to ask all the right questions and explore all options and avenues of care. I am 55, was diagnosed with Multiple Myeloma on July 9, 2025. To my disappointment I learned (in preparation for an evaluation with a MM specialist) my hematologist/oncologist identified my diagnosis date as 5/22 and test results support the diagnosis on this date. However I was not verbally informed until 7/9, after a PET Scan on 6/17 and a bone marrow biopsy on 6/19, that I have Multiple Myeloma and started induction therapy on 7/16 with the 4 drug regimen D-VdR. I am a good patient and believe in medicine and my drs and follow instruction/advice to the tee. I am that can do person. However I realize I need to be extremely proactive and informed in this case with my Myeloma. I want to be the co-pilot versus a back seat driver and plan to educate myself and utilize the amazing resources and network provide by the HealthTree Foundation. Denise