The measles virus grabbed media attention with one patient's amazing outcome. Dr. Russell and Dr. van Rhee hope to expand those results into more patients with lessons learned from the first clinical trials. Phase I was a trial of six patients and now phase II is running at the Mayo Clinic for 42 patients with the measles virus alone. The proposed work for the MCRI is a collaboration between UAMS and the Mayo Clinic to treat 16 patients in a now-open clinical trial using a lower dose of the measles virus in combination with cyclophosphamide. To date, the doctors found that patients with an absence of the measles antibody and a low tumor burden responded the best to the treatment. In this show they describe how the immune system, no matter how weak, mounts a response to the measles virus given and how they would like to use the predictable cyclophosphamide in conjunction with the measles virus to buy the immune system more time and allow the measles virus to attack more myeloma cells. They will also be using imaging as a key tool to show where the measles virus is going inside of the body and how effective the treatment is. There is much to be learned from this show about a non-toxic approach to myeloma therapy. Hear more about the initial results and how the measles virus works here.  The Myeloma Crowd Radio Show with Dr. Frits van Rhee and Dr. Stephen Russell