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Data, Tissue, Blood, and Urine Repository for Amyloid Diseases


RATIONALE: Collecting and storing samples of blood, urine, tissue and data from patients with amyloid diseases to test in the laboratory may help the study of this disease in the future. PURPOSE: This research study is collecting samples from patients with amyloid diseasesOBJECTIVES: To establish and maintain a database of clinical material (i.e., blood, urine, and tissue) and information on patients with amyloid diseases. OUTLINE: Blood, urine, tissue, and bone marrow samples are collected during standard laboratory evaluations to maintain a repository of biospecimens in the Gerry Amyloid Research Laboratory, to permit the correlation of clinical results with measured biological events, and for future research studies. Bone marrow RNA samples are examined for immunoglobulin light-chain gene sequences and amino acids by polymerase chain reaction and positional cloning. Blood serum and urine samples are evaluated for amyloid protein stability by high-resolution calorimetry, isotherma

Trial Eligibility

Inclusion Criteria: DISEASE CHARACTERISTICS: Diagnosis or suspicion of amyloidosis PATIENT CHARACTERISTICS: Referred to the Amyloid Treatment and Research Center at Boston University Medical Center PRIOR CONCURRENT THERAPY: Not specified Exclusion Criteria: None

Study Info


Boston Medical Center

Primary Outcome

Establish a repository to promote biochemical research

Outcome Timeframe life of study

NCTID NCT00898235

Completion Date December 2040


Genetic clonality analysis

Genetic polymerase chain reaction

Genetic protein analysis

Other biologic sample preservation procedure

Other laboratory biomarker analysis

Procedure fluorescence spectroscopy

Procedure quality-of-life assessment

Locations Recruiting

Boston University Cancer Research Center

United States, Massachusetts, Boston

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