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Signs And Symptoms Of Myelofibrosis

The signs and symptoms of myelofibrosis can vary from person to person and may change over time. Some individuals may experience mild symptoms, while others may have more pronounced effects. Here are the common signs and symptoms associated with myelofibrosis:

  • Fatigue and weakness: Feeling tired or weak even with minimal physical activity.
  • Anemia: Myelofibrosis can lead to a decreased production of red blood cells, resulting in anemia. Anemia can cause symptoms such as pale skin, shortness of breath, dizziness, and rapid heartbeat.
  • Easy bruising and bleeding: Due to abnormal platelet function and reduced platelet count, individuals may experience easy bruising, frequent nosebleeds, bleeding gums, and prolonged bleeding after minor injuries or surgeries.
  • Enlarged spleen (splenomegaly): The accumulation of abnormal blood cells in the bone marrow can cause the spleen to enlarge. This can cause pain or a feeling of fullness or discomfort in the left upper abdomen.
  • Enlarged liver: In some cases, myelofibrosis can lead to the enlargement of the liver, causing abdominal discomfort or pain in the right upper abdomen.
  • Night sweats: Many individuals experience excessive sweating during sleep.
  • Bone pain: Myelofibrosis can cause bone pain, particularly in the back, ribs, hips, and legs. This pain may be a result of the fibrous tissue replacing the bone marrow.
  • Weight loss and decreased appetite.
  • Frequent infections: Abnormalities in white blood cell production and function can weaken the immune system, making individuals more susceptible to infections.
  • Itching (pruritus): Itchy skin, often without a visible rash, can occur. (The exact cause of this symptom is not well understood.)

It's important to note that these symptoms are not exclusive to myelofibrosis and can be present in other medical conditions as well. If you experience any persistent or concerning symptoms, it's recommended to consult a healthcare professional for an accurate diagnosis and appropriate management.


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