• Myelofibrosis

I am a translational cancer researcher in the field of myeloid malignancies, with a focus on myeloproliferative neoplasms (MPN). My laboratory studies the biology, genetics, and therapy of myeloid cancers using primary human samples, murine models and multiple in vitro model systems. We use standard biochemical assays, proteomics, multi-parameter flow cytometry, in vivo functional genomics (including CRISPR) and next generation sequencing technologies. Current projects in my laboratory are focused on the biology of mutant calreticulin in MPN, hematopoietic-stromal interactions in the context of myelofibrosis, , the differential molecular dependencies of disease-propagating stem cells in myeloid cancers, identification of heritability alleles for familial MPN. My laboratory is actively expanding currently so please contact me if you are an exceptionally motivated post-doctoral candidate interested in joining my group.