Myelofibrosis Fatigue: Causes and Ways to Manage

What causes myelofibrosis-related fatigue, and how can you manage it?

Fatigue is often described as deep, persistent exhaustion that can interfere with daily life. It is one of the most common and challenging symptoms faced by people living with myelofibrosis. In this article, you'll learn why fatigue occurs and what steps you can take to manage this symptom better. 

Understanding why fatigue happens in myelofibrosis

In myelofibrosis, the bone marrow becomes scarred, which makes it harder for the body to produce healthy blood cells. This leads to anemia, or a low number of red blood cells, which reduces the amount of oxygen that can be carried throughout the body. Low oxygen levels make it difficult for the body to produce energy, causing myelofibrosis patients with anemia to feel extremely tired. 

However, anemia is not the only cause. Other fatigue contributors can include:

• Chronic inflammation seen in myelofibrosis
• Emotional health challenges like depression or anxiety
• Poor sleep quality

Certain demographic and lifestyle factors may also increase fatigue. Studies have found that younger individuals, women, and those with higher body mass index (BMI) often report more fatigue. Other medical conditions, like thyroid problems or vitamin deficiencies, can also play a role. 

Medicines prescribed for other reasons, such as antihistamines or pain relievers, may make fatigue worse. Discussing all current treatments with a healthcare provider is important to rule out medicines contributing to tiredness.

How fatigue impacts daily life

Fatigue can affect people with myelofibrosis in different ways. Common experiences include weakness, forgetfulness, light-headedness, sleep disturbances, and reduced motivation or emotional stability. 

Patients often describe struggling to complete everyday tasks, feeling dizzy, or lacking the energy for activities they once enjoyed. These symptoms may lower your quality of life. Continue reading to learn about resources to support you.

Ways to manage myelofibrosis-related fatigue

While fatigue can be difficult to treat completely, several strategies may help improve your energy levels and quality of life.

Lifestyle adjustments

Increasing physical activity, when possible, has been shown to reduce fatigue. A simple walking program or light exercise can make a difference. 

Maintaining a consistent sleep schedule is also important for getting regular, restful sleep. Good sleep hygiene includes avoiding stimulants before bedtime, maintaining a comfortable room temperature, and limiting naps during the day. 

Lowering inflammation via the ways discussed here can also help reduce fatigue. 

Practical tips for saving energy

Planning your day to include rest breaks can help conserve energy. People may find that pacing household chores, using labor-saving devices, and asking for help from family or friends reduces fatigue.

At work, discussing accommodations with an employer may be helpful. Options include flexible schedules, working from home, or modifying duties to avoid heavy physical tasks.

Emotional and mental health support

Fatigue can sometimes be linked with feelings of stress, depression, or anxiety. Talking openly with healthcare providers about emotional health is important. You may also benefit from counseling or medications that address mood-related issues.

Connecting with others who have myelofibrosis through support groups or online communities, like HealthTree Connect, can also offer comfort and helpful tips.

Treatment options

Some people with myelofibrosis have found that treatments such as ruxolitinib (Jakafi, Incyte) may improve fatigue. While not everyone will experience relief, it is worth discussing with your myelofibrosis specialist if fatigue significantly impacts daily life.

Partnering with your healthcare team

Managing fatigue requires ongoing conversations with your care team. They can help identify underlying causes, adjust treatments, and recommend resources to improve daily functioning. 

Key takeaways

Fatigue in myelofibrosis is common and can be caused by anemia, inflammation, and emotional or lifestyle factors. While it can be difficult to manage, strategies like staying active, maintaining good sleep habits, reducing inflammation, pacing activities, and seeking emotional support can help. Work closely with your healthcare team to find the best approach for you. 

Continue Reading Myelofibrosis News

Sources: 

• Comprehensively Understanding Fatigue in Patients with Myeloproliferative Neoplasms
• Fighting Fatigue - MPN Voice
• Managing Fatigue with MPNs
• Key Role of Inflammation in Myeloproliferative Neoplasms: Instigator of Disease Initiation, Progression, and Symptoms