Do I need to start treatment right away?

Do I need to start treatment right away? Here again, you can split all MDS patients into low risk and into high risk. Okay, so the way we think about low and high risk is that high risk patients, biggest worry we have is that MDS now becoming acute leukemia and that leukemia can be lethal, right? And so that's the major problem. With low risk MDS, what you see are you see people with low blood counts, right? They could have anemia, they could have low platelets, right? That cause bleeding or anemia that causes fatigue. And so there, patients might live for a long time with those conditions. So a portion of those patients, we would not treat unless their anemia was symptomatic or their blood count issue was symptomatic, right? Because if it's not symptomatic, then the patient is asymptomatic and any treatment you give them can potentially cause symptoms, right? So what we want to do is we want to maximize in low risk patients the quality of life, right? Things that impinge upon that are the symptoms you have from your blood counts being low, the need to get a transfusion frequently, that's oftentimes a problem. And so we balance out, does the patient really need treatment like a transfusion right now? Or can we know that they have MDS, but they might be fine, so we might just wait and not treat them at all.