What symptoms indicate relapse? So those would all be problems that arise from low blood counts. So those would be things like if you have anemia in your fatigue, that could be a sign. If you have what's called thrombocytopenia, your platelets are low, then you could develop bleeding. If you develop gum bleeding, they could have blood in their urine, they could have blood in their stool, all of those, that's bleeding. Or if your white blood cell count is low, you're not susceptible to other infections and so the things that come up with infections, you have fevers, chills, do you have problems breathing if you develop a pneumonia, do you have problems urinating if you develop a bladder infection. So it just makes you more susceptible to infections and so it's really not like a lumpy feel it's really more like what are the problems that arise from having low blood counts in general. Symptoms for MDS patients who might be relapsing include worsening fatigue, an increasing amount of infections, easy bruising and bleeding, and getting shortness of breath when they previously wouldn't get short of breath.