Should You Use the Best Myeloma Treatments Early or Save Them for Relapse?

Rafael Fonseca, MD, of Mayo Clinic Arizona discusses treatment attrition between lines of therapy at IMS 2026 in Glasgow. Attrition is the pattern where some patients never reach the next line of treatment because of disease progression or complications. He reviews the large studies behind the concept and new data showing attrition is falling but remains high for older patients. His key takeaway: the best available treatments should be used up front rather than saved for later.

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Timestamps:
0:00 Introduction: Dr. Rafael Fonseca, Mayo Clinic Arizona
0:11 What Is Treatment Attrition?
0:59 The Research Behind Attrition
1:33 New Data: Attrition Is Falling, But Still High in Older Patients
2:06 Why the Best Treatment Should Come First