What are the common side effects of Vyxeos and how are these side effects managed?

What are the common side effects of Vyxeos and how are these side effects managed?

So the side effects that you see with Vyxeos are very similar to what you see with really any type of induction chemotherapy for AML. The main side effects are related to lowering of blood counts, so patients are more susceptible to infections and the manifestations of infections like fevers and chills and other signs and symptoms of infection. You can see serious infections with Vyxeos treatment that is related to the suppression of the blood counts and the risk for different types of infections, especially fungal or mold infections when the white blood cells are very low. But that's not unique to Vyxeos. It's commonly seen with many different types of induction chemotherapy. I think with Vyxeos, the one perhaps outlying side effect is that there tends to be a more delayed time to recovery of white blood cell counts and platelet counts in particular. It probably reflects the fact that the Vyxeos is in the circulation for longer, it doesn't get broken down as quickly. So the overall exposure to the drug is longer and therefore the blood count recovery takes longer. But at the same time, we think that it works better in secondary AML compared to 7+3. So the tradeoff is a little bit more of a delay in count recovery for improved efficacy.