BETA - What is IgM MGUS?

[Music] what is IG mm guess so when we talk about an M Gus or Marlon gum mechanic yeah come see this and this is why we don't we call it an M gas monoclonal gammopathy of uncertain significance is that you have this protein this antibody in your blood that is sitting there and it's a monoclonal protein there's an excess of it and it's identical and so that is not that's akin to when your myeloma is making the antibody but when you have an M Gus you have the antibody but we don't find an excess of any myeloma cells or lymphoma cells or any kind of cancerous cells that are making it the protein is there by itself and so it's unclear what that means and some patients will eventually develop myeloma or lymphoma and some patients will never develop any of these diseases IgM M gus is just a subtype of M Gus so there are there's a small group of patients that have an IgM instead of an IgG or an IgA and an IgM M Gus usually is more likely to become this thing called Waldenstrom's macroglobulinemia which is a subtype of an indolent lymphoma so when you look at myeloma and lymphoma their sister diseases because they arise from the same cell it just depends on what level of their differentiation so all B lymphocytes eventually mature can mature into a plasma cell so if your disease mutates at the level of the lymphocyte you develop lymphoma if you disease mutates at the level of the lymphocyte that's becoming a myeloma cell we called a little info plasma siddik lymphocyte that becomes Waldenstrom's and that's more likely to make a GM if mutates at the point where it becomes a plasma cell it becomes multiple myeloma [Music]