Phase 1 / 2 Trial of Blood-brain Barrier Opening With an Implantable Ultrasound Device SonoCloud-9 and Treatment With Albumin-bound Paclitaxel and Carboplatin in Patients With Recurrent Glioblastoma

Description

Paclitaxel is among the most active agents against glioblastoma in preclinical models. However, its clinical use has been hampered by the blood-brain barrier (BBB). In this trial we will implant a novel device with 9 ultrasound emitters allowing to temporarily and reversibly open the BBB immediately prior to chemotherapy infusion with albumin-bound paclitaxel. In the phase 1 component, increasing doses of chemotherapy will be delivered as long deemed safe based on the prior patient not experiencing severe toxicity. Once the the recommended dosing has been established, carboplatin will be added to the regimen and additional patients will be treated in order to better evaluate the antitumor efficacy of this novel treatment. The device will be implanted at the time of surgical resection of the recurrent tumor. During that procedure and when feasible, a first test dose of the chemotherapy will be administered in the operating room after sonication (procedure of activating ultrasound and

Trial Eligibility

Inclusion Criteria: 1. Confirmed diagnosis of Isocitrate Dehydrogenase 1 (IDH1) wild-type glioblastoma on pathology from initial surgery (e.g. IDH R132H neg); morphologic or molecular determination of grade 4 2. Ability to undergo contrast-enhanced MRI 3. Radiographic evidence of tumor recurrence/progression after failure of 1 - 2 lines of prior therapy 4. Measurable or evaluable disease 1. Measurable: contrast-enhancement (bidirectional diameters ≥ 1cm) on MRI 2. Non-measurable/evaluable: contrast-enhancement diameters \< 1 cm 5. Maximal tumor diameter pre-surgery ≤ 70 mm on T1wMRI 6. Candidate for at least partial surgical resection 7. Greater 12 weeks from completion of radiation therapy 8. Age ≥ 18 years 9. If receiving dexamethasone for mass effect, a stable daily dose of dexamethasone at \< 6 mg within 7 days of registration, or if dexamethasone dose is decreasing, average daily dose of \< 6 mg in the 7 days prior to registration. Patients on dexamethasone for reasons other than mass effect may still be enrolled. 10. WHO performance status ≤ 2 (equivalent to Karnofsky Performance Status (KPS) of ≥70) 11. Adequate hepatic, renal and bone marrow function, documented with normal laboratory values or no more than grade 1 outside the norm performed within 14 days prior to registration 12. For patients with a childbearing potential 1. Negative pregnancy test within 14 days prior to registration 2. Agreement to use adequate contraception for the duration of study participation, and for 3 and 6 months after the last dose of albumin-bound paclitaxel for men and women of childbearing potential, respectively. 13. Have the ability to understand and the willingness to sign a written informed consent prior to registration on study 14. Be willing and able to comply with the protocol for the duration of the study 15. Provide written, signed and dated informed consent prior to study registration. NOTE: no study-specific screening procedures may be performed until written consent has been obtained Exclusion Criteria: 1. Have multifocal disease that cannot be encompassed in the ultrasound fields: 1. e.g. \> 70-mm apart 2. tumor located in the posterior fossa 2. Patients at risk of cranial wound dehiscence 3. Have uncontrolled epilepsy or require treatment with enzyme-inducing antiepileptics 4. Have clinical evidence of peripheral neuropathy on examination 5. Have received any other investigational agents within 4 weeks of registration 6. Have received prior therapy with or have history of allergic reactions attributed to compounds of similar chemical or biologic composition to paclitaxel or carboplatin 7. Medical contraindications to Abraxane® or carboplatin 8. Have an uncontrolled intercurrent illness 9. Are pregnant or nursing 10. Have a history of active malignancy within 3 years prior to registration. 11. Have a known history of hypersensitivity reactions to perflutren lipid microsphere components or to any of the inactive ingredients in Definity® (the FDA-approved ultrasound contrast agent to be used in this study) 12. Patients with coils, clips, shunts, intravascular stents, and/or non-removable wafer, non resorbable dura substitute, or reservoirs. 13. Patients with medical need to continue antiplatelet therapy. 14. Patients with known significant cardiac disease, known to have right-to-left shunts, severe pulmonary hypertension (pulmonary artery pressure \> 90 mmHg), uncontrolled systemic hypertension, or adult respiratory distress syndrome (patient at risk for microbubble reaction). 15. Patients with impaired thermo-regulation or temperature sensation (due to device)

Study Info

Interventions

Locations Recruiting

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