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Thumbnail for MajesTEC-3: Could Teclistamab + Daratumumab Lead to a “Functional Cure” in Myeloma? | IMS 2026
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MajesTEC-3: Could Teclistamab + Daratumumab Lead to a “Functional Cure” in Myeloma? | IMS 2026

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Thumbnail for MajesTEC-5: High MRD-Negative Rates With Talquetamab Combo in Newly Diagnosed Myeloma | IMS 2026
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MajesTEC-5: High MRD-Negative Rates With Talquetamab Combo in Newly Diagnosed Myeloma | IMS 2026

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Thumbnail for CARTITUDE-2: Can Earlier Cilta-Cel CAR-T Lead to Long-Term Remission or Cure in Myeloma? | IMS 2026
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CARTITUDE-2: Can Earlier Cilta-Cel CAR-T Lead to Long-Term Remission or Cure in Myeloma? | IMS 2026

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Thumbnail for ENDURANCE Trial: Can Myeloma Patients Stop Revlimid Maintenance After 2 Years? | IMS 2026
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ENDURANCE Trial: Can Myeloma Patients Stop Revlimid Maintenance After 2 Years? | IMS 2026

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Thumbnail for How Is Myeloma Treatment Changing? Quadruplets, CAR-T, Bispecifics and New Therapies | IMS 2026
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How Is Myeloma Treatment Changing? Quadruplets, CAR-T, Bispecifics and New Therapies | IMS 2026

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Thumbnail for Personalized Vaccine for Smoldering Myeloma: Could It Prevent Progression? | IMS 2026
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Personalized Vaccine for Smoldering Myeloma: Could It Prevent Progression? | IMS 2026

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JoshHolt
Multiple Myeloma Discussion • October 6
Pain management
I'm all about the natural side of thinks, into naturopathy and am trying to avoid any opioids but it's getting to interfere with my quality of life, wondering what everyone does for pain management?
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nancynomad
Multiple Myeloma Discussion • October 5
Hyperlipidemic myeloma and MAGa
I believe I may have hyperlipidemic myeloma, a rare variant of myeloma which leads to high levels of cholesterol (usually MM is associated with low or normal cholesterol levels), possibly by decreased lipid degradation due to paraproteins complexing with lipoproteins, impaired lipolytic activity and paraprotein binding the LDL receptor inhibiting clearance. See “Elevated LDL Secondary to MM” https://www.lipid.org/resource/elevated-ldl-secondary-to-multiple-myeloma/. If it is due to paraproteins binding with lipoproteins, it would be a form of MAGa – monoclonal autoimmune gammopathies. While the origin of the antibody is a neoplastic clone of cells rather than a standard systemic autoimmune defect, the end result—a self-protein being targeted and disrupted by an antibody—is functionally an autoimmune phenomenon. From “MAGa: Monoclonal Autoimmune Gammopathies” published May 27, 2026 https://www.mdpi.com/2072-6694/18/11/1770: “monoclonal immunoglobulins (as measured in the M-spike), have long been overlooked in clinical research because they are thought to have no significant antibody function…In monoclonal autoimmune gammopathies (MAGa), repeated exposure to autoantigens may contribute to the development of multiple myeloma. Alternatively, these associations could reflect an underlying immune disorder that exists years before the diagnosis of multiple myeloma, thereby illustrating the natural course of the disease.” There are tests which can confirm both diagnoses, which I hope to have soon. But I wanted to ask, does anyone have any experience with hyperlipidemic myeloma or with MAGa?
Elevated LDL Secondary to Multiple Myeloma | NLA

Elevated LDL Secondary to Multiple Myeloma | NLA

A case of elevated LDL cholesterol secondary to multiple myeloma, and why secondary causes of hyperlipidemia deserve evaluation before treatment.

https://www.lipid.org/resource/elevated-ldl-secondary-to-multiple-myeloma/
Thumbnail for Talquetamab Taste Changes in Multiple Myeloma: What Helps and What Doesn’t? -TALISMAN Study | #IMS26
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Talquetamab Taste Changes in Multiple Myeloma: What Helps and What Doesn’t? -TALISMAN Study | #IMS26

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