Hello- wondering if anyone is involved with a trial AZD0305. It targets GPRCH5. I am 20 month post Car T (Carvykti ) and relapsing. Small lesion in my pelvis and Kappa climbing monthly (16 then 25 now 60). So not awful but in light of lesion and climbing kappa monthly we need to start treatment due to my history of developing lesions with small kappa numbers. I treat at U of Penn. Thanks for any information available to share.

Hello- wondering if anyone is involved with a trial AZD0305. It targets GPRCH5. I am 20 month post Car T (Carvykti ) and relapsing. Small lesion in my pelvis and Kappa climbing monthly (16 then 25 now 60). So not awful but in light of lesion and climbing kappa monthly we need to start treatment due to my history of developing lesions with small kappa numbers. I treat at U of Penn. Thanks for any information available to share.

Was diagnosed July 2021 didn’t do sct did the standard treatment Dara Velcade dex revlimid and zometa got very good results on maintenance with 5 milligrams Revlimid since January 2024. Developed prostate cancel had to do 5 days a week for 6 weeks radiation. That’s under control feeling good. Doc wants me to get a pet scan with contrast, very worried about all the radiation I’m getting. Since 2021 had 2 pet scans ct scans X-rays shoulder jaw elbows . Doc says it’s a small amount and dismisses my concerns. Does anyone have any advice for me?

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Hello - wondering if anyone is part of the Etentamig trial and how it is going. My doctor is suggesting it for me. Where was your m- protein when you started? Thanks -

Hello, I was diagnosed with an almost 9cm solitary plasmacytoma on my sacrum in Oct 2025. I had an M-spike upon diagnosis which they said was due to the tumor being secretory. Bone marrow biopsy was clear. I was given 25 rounds of radiation to cure it, but the tumor has not responded (shrunk) at all. M-spike has come down roughly 50%. I'm in terrible pain all the time from this tumor. Does anyone have experience with something like this? I keep asking about a surgical solution, but they are saying chemo would be the next step. I would like to avoid chemo since it is a localized problem. Any advice is welcome. Also has anyone had one surgically removed?

Hello For all of you who are currently enrolled in a Medicare Advantage Plan, you can change plans during the Medicare Advantage Open Enrollment Period which began Jan 1st - March 31st. Please review your plans as there have been a lot of changes in what plans cover. You can also choose to go back to Original Medicare, which is Part A and B. If this is something you are considering, understand that of you don't have a supplemntal plan such as an Advantage Plan or a Medigap Plan, you will be responsible 20% of everything. There is no cap. Check to see if your state will allow you to change to a Medigap Plan even after your initial enrollment period is over. Please reach out to a financial coach to help you navigate these issues. We want you to be aware, knowledgeable about you options and covered for treatment.

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Hello all, I've been SMM for more than 5 years. I am beginning to have reoccurring back pain. I have upcoming appointments for Bone marrow and MRI. That said, I recently threw my back out and can barely move, walk, lay, or sit (don't know how I'm going to do these tests). I walk slowly around my home and am losing all muscle in my legs, arms, abdomen. Any recommendations for any exercise that doesn't cause added pain?

Hello, I am writing on behalf of my mom who just recieved her diagnosis in early January. Her Myeloma is very progressed, and she is entering into cancer treatment under weight and in a lot of pain. Would any of you be willing to share what your pain protocol is and how you have kept up your appetite?

Hello, I was newly diagnosed with lambda lightchain in June 2025. I had had the disease for some time apparently, was in kidney failure, and had many lesions and vertebral issues. I have responded very well to DRVd, with serum tests showing normal light chain numbers. At six months they did a biopsy but did not get enough material to get an accurate read on MRD. The doc's don't seem to want to do another biopsy because of the serum numbers. Does that make sense? They are continuing with quadruplet therapy for now, beginning cycle 7. They gave me a full two months with no treatment due to stem cell harvesting, shortly after the failed biopsy and other tests required for that. Thoughts??? I don't know why we wouldn't do another MRD biopsy.

Just looking to see how you handled the harvesting and the transplant. Anything you would do differently? Any suggestions ? I start harvesting next week followed by the transplant.

I’m wondering if anyone in this group has experience with carfilzomib, im currently using this med as part of a bridging treatment. Just wondering, Cheers

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Hi everyone! Has anyone in this group received clonoSEQ tests and would be interested in sharing about their experience? Thank you!