What are the latest advancements and future directions in the development of CAR T-cell therapy for diffuse large B-cell lymphoma?

What are the latest advancements and future directions in the development of CAR T-cell therapy for diffuse large B-cell lymphoma?
How does risk stratification affect treatment decisions for newly diagnosed DLBCL?
What are the first-line treatment options for newly diagnosed DLBCL, and why are they chosen?
What is the role of rituximab (the "R" in R-CHOP) in treating newly diagnosed DLBCL? What are its side effects and how are they managed?
What are challenges associated with using real world data?
What are challenges associated with using real world data?