24 years treating AML
Dr. Rizzieri focuses on developing new therapies for patients with leukemia or lymphoma. He is a member of the Combined International Bone Marrow Transplant Registry Lymphoma Writing Committee and the ALLIANCE (formerly CALGB) Leukemia Core Committee and NCI Leukemia Working Groups. Dr. Rizzieri serves as chair or co-chair of multiple ALLIANCE lymphoma/ leukemia trials, the most recent being the last two national studies for Burkitt’s lymphoma, as well as the current leukemia in under 60-year-olds study. He has led their team’s novel approaches for the care of patients using monoclonal antibodies with non-myeloablative allogeneic therapy to optimize a less toxic regimen for transplant of patients with hematologic malignancies using haplo-identical, as well as matched, donors. This work is currently being extended with post-transplant graft manipulation studies focused on manipulating Natural Killer cell activity. Dr. Rizzieri has led the development of anti-stromal therapy in lymphoma using new antibodies targeting the stromal protein, tenascin, for which a patent is pending, and first in-human studies targeting acute myelogenous leukemia by linking diphtheria to an antibody to the IL-3 receptor.