Dr. Sach's goal is to identify molecular mechanisms of leukemia stem cell self-renewal in primary murine and human acute myeloid leukemia (AML). Self-renewal is a feature of leukemia stem cells that allow them to recapitulate leukemia and cause relapse. Since AML cells are highly heterogenous, his lab specializes in the application of single-cell, high throughput technologies (including mass cytometry/CyTOF and single-cell RNA sequencing) to address these research questions.

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