What is a 17p deletion? Why is del of 17p considered high risk?

What is a 17p deletion? Why is del of 17p considered high risk?
Why is chromosome 14 a site of high-risk myeloma genetics? What is the job of chromosome 14?
(Guest Lecture): Balancing Today with Tomorrow’s Opportunity | MCRT Webcast: Why Physicians Are Optimistic About Newly Diagnosed Myeloma
(Guest Lecture): A Discussion of Two Case Studies | MCRT Webcast: Why Physicians Are Optimistic About Newly Diagnosed Myeloma
(Guest Lecture): An Increasing Arsenal of Therapeutic Options | MCRT Webcast: Why Physicians Are Optimistic About Newly Diagnosed Myeloma
(Guest Lecture): The Ever-Changing Landscape of Treatment | MCRT Webcast: Why Physicians Are Optimistic About Newly Diagnosed Myeloma
What chromosomal abnormalities are considered high-risk, standard risk?
What is the definition of high-risk multiple myeloma (HRMM)?