There are no absolute contraindications listed for nelarabine, but it should be used with caution in certain situations.

Patients with a history of severe neurological disorders or who have received prior treatments that can affect the nervous system (such as intrathecal chemotherapy or craniospinal irradiation) may be at higher risk for serious side effects. Nelarabine can cause harm to an unborn baby, so it should not be used during pregnancy unless clearly needed. Women of childbearing age should use effective contraception, and men should use condoms during treatment and for 3 months after the last dose.

Patients should not receive live vaccines while on nelarabine, and those with significant kidney or liver impairment should be monitored closely, as the drug has not been well studied in these populations.

nelarabine

Common brand names

Approved use in