Gallbladder Cancer Symptoms

What are the early symptoms of gallbladder cancer?

Early gallbladder cancer often causes no noticeable symptoms. This is one reason the disease can be difficult to diagnose before it has grown or spread. When symptoms occur, they may be similar to those caused by gallstones, gallbladder inflammation, liver disease, or other digestive conditions.

Common symptoms of gallbladder cancer

Abdominal pain

Pain in the upper right portion of the abdomen is one of the most common symptoms. The pain may be:

• Persistent or intermittent

• Dull or aching

• Located beneath the right rib cage

• Occasionally felt in the back or right shoulder

Abdominal pain has many possible causes, and most people experiencing it do not have gallbladder cancer.

Jaundice

Jaundice causes yellowing of the skin or whites of the eyes. It occurs when bilirubin, a yellow substance produced during the breakdown of red blood cells, builds up in the body. Gallbladder cancer may cause jaundice if a tumor blocks the flow of bile. Other symptoms associated with bile duct blockage may include:

• Dark urine

• Pale or clay-colored stools

• Itchy skin

Nausea and vomiting

Some people experience persistent nausea, vomiting, or general digestive discomfort. These symptoms may be related to the cancer itself, bile duct obstruction, or other medical conditions.

Loss of appetite

Gallbladder cancer may cause reduced appetite or feeling full after eating small amounts of food.

Unexplained weight loss

Losing weight without trying can be a symptom of many cancers, including gallbladder cancer.

Fever

Fever may occur, particularly when bile duct blockage leads to inflammation or infection.

Abdominal bloating

Some people experience a feeling of fullness, swelling, or bloating in the abdomen.

Symptoms of advanced gallbladder cancer

Advanced gallbladder cancer may cause:

• Persistent or worsening abdominal pain

• Significant weight loss

• Severe jaundice

• Abdominal swelling caused by fluid accumulation, called ascites

• Increasing fatigue

• Difficulty eating

• Symptoms related to spread to other organs

When should you see a doctor?

Contact a healthcare professional if you experience persistent upper abdominal pain, unexplained weight loss, ongoing nausea, or other concerning symptoms. Seek urgent medical evaluation if you develop jaundice, especially when accompanied by fever, chills, or abdominal pain. These symptoms can indicate a blocked or infected bile duct that requires prompt treatment.