Cereblon E3 ligase modulators (CELMoDs, Iberdomide)

This class of drug called CELMoDs are functionally different from the immunomodulators. CELMoDs are larger molecules and work by quickly degrading a specific set of proteins (called Ikaros and Aiolos). They are potent modulators of the cereblon E3 ligase complex.They also stimulate the immune system and kill myeloma cells directly, even for myeloma that has become resistant to certain therapies. It is synergistic with other therapies and has excellent tumor penetration.