What is the difference between a vaccine that is personalized and a shared (off the shelf or allogeneic) vaccine?

What is the difference between a vaccine that is personalized and a shared (off the shelf or allogeneic) vaccine?
What are cancer vaccines and how do they work? What side effects are being seen with myeloma vaccines? Have any cancer vaccines been FDA approved?
How are vaccines made? What are vaccine adjuvants (immune stimulators)?
How is frailty defined? What does it mean to be fit, intermediate-fit, frail?