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rubyCrocodile
Multiple Myeloma Discussion • January 7, 2025
Concern About Fluctuating K/L Ratio Post-SCT
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HI, I had SCT in May. I have IGG Kappa. My light chains are staying within range but Kappas are close to the top of the range and fluctuate a lot. The Kappa/lambda ratio is usually 0.80-.90 but lately Lambda is lower than Kappa and ratio is around 1.10. Is that normal? Is it ok for Kappa's to be close to top of the range? It makes me concerned when it reaches near the top of the range.
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shaila02784@yahoo.com
Multiple Myeloma Discussion • January 7, 2025
Sharing CAR-T Bridging Therapy Experiences?
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Hi, for those who have gone through CAR-T, have you had any bridging therapy before that to bring myeloma under control? Could you please share what treatment you were on as part of the bridging therapy? I have relapsed/became refractory to all the other off the shelf treatments and now my doc is recommending DCEP which I do not want to proceed with and trying to see if there are still other alternatives. Thank you
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silverLadybug
Multiple Myeloma Discussion • January 7, 2025
Light Chain Test Accuracy and Variability?
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Dear Myeloma Community, Great day, I am 70 years old, diagnosed with Myeloma since almost two years. I am now on Lenalidomide 10mg maintenance dose. I am monitoring the Kappa Light Chains, being my type of disease, as an important marker for progression. I have no m-spike. The outcomes are different from Lab to Lab. Such as I got 129 from one lab and 89 from the other with 1 day difference between giving the blood samples. My question: did anybody come across the question of the accuracy/ tolerance of this test? Is it plus or minus 5%, 10% or? I am not able to judge or find an answer. My doctor says I don't need further tests like a Biopsy or PET, but we need to monitor my condition monthly. Please let me know if you have a similar situation or can help somehow with an advice. Rgds to all
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